Results 41 to 50 of about 33,788 (287)

Differential roles of calcitonin family peptides in the dendrite formation and spinogenesis of the cerebral cortex in vitro [PDF]

, 2011
We examined roles of calcitonin family peptides in the initial stages of dendrite formation and the maturation of dendritic spines in the rat cerebral cortex in vitro.
Harigai Yuichi, Li Fei, Natsume Masaki, Ohtani Akiko, Senzaki Kouji, Shiga Takashi, 先崎 浩次, 志賀 隆   +7 more
core   +1 more source

Gα_s-Coupled CGRP Receptor Signaling Axis from the Trigeminal Ganglion Neuron to Odontoblast Negatively Regulates Dentin Mineralization

Biomolecules, 2022
An inflammatory response following dental pulp injury and/or infection often leads to neurogenic inflammation via the axon reflex. However, the detailed mechanism underlying the occurrence of the axon reflex in the dental pulp remains unclear.
Natsuki Saito, Maki Kimura, Takehito Ouchi, Tatsuya Ichinohe, Yoshiyuki Shibukawa   +4 more
doaj   +1 more source

High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors

Molecular Pain, 2009
Background Morphine and its derivatives are key drugs in pain control. Despite its well-known analgesic properties morphine at high concentrations may be proalgesic.
Messlinger Karl, Reeh Peter W, Forster Alexander B, Fischer Michael JM   +3 more
doaj   +1 more source

N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. [PDF]

, 2017
N-Arachidonoyl dopamine (NADA) is an endogenous lipid that potently activates the transient receptor potential vanilloid 1 (TRPV1), which mediates pain and thermosensation. NADA is also an agonist of cannabinoid receptors 1 and 2.
Hellman, Judith, Lawton, Samira K, Prakash, Arun, Schumacher, Mark, Tran, Alphonso, Wilhelmsen, Kevin, Wong, Erika, Xu, Fengyun   +7 more
core   +2 more sources

The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class-Effect Synergy in Experimental Arthritis [PDF]

, 2013
PMCID: PMC3564948This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Grieder, Adam Al-Kashi, AE Koch, AJ Janckila, B Joe, BC Sondergaard, C Di Filippo, C Gannon, DD Brand, DH Copp, DR Mitchell, E Smith, F Buttgereit, GR Zimmermann, H Schacke, H Smolian, I MacIntyre, JA Cidlowski, JA Da Silva, JA Whitworth, James P. Gilligan, JB Smith, JJ Body, JM Stuart, John Wallace, K De Bosscher, K Henriksen, KS Kim, L Mancini, LI Plotkin, M Cochran, M Paul-Clark, M Yamaguchi, M Yamaguchi, M Yamaguchi, M Zaidi, MA Karsdal, MA Karsdal, Mauro Perretti, MF Fredin, MJ Peters, MR Edwards, N Binkley, N Mukaida, Niloufar Moradi-Bidhendi, Nozer Mehta, PJ Barnes, PJ Barnes, RA Nathan, RI Scheinman, S Aida, S van Wetering, SE Abdullahi, T Rhen, Trinidad Montero-Melendez, YH Chang   +55 more
core   +5 more sources

Migraine pathogenesis and state of pharmacological treatment options

BMC Medicine, 2009
Migraine is a largely inherited disorder of the brain characterized by a complex, but stereotypical, dysfunction of sensory processing. Often the most obvious clinical symptom is head pain, but non-headache symptoms such as photophobia, phonophobia and ...
Goadsby Peter J, Sprenger Till
doaj   +1 more source

Role of PACAP in migraine: An alternative to CGRP?

Neurobiology of Disease, 2023
Migraine is a widespread and debilitating neurological condition affecting more than a billion people worldwide. Thus, more effective migraine therapies are highly needed. In the last decade, two endogenous neuropeptides, calcitonin gene-related peptide (
Song Guo, Inger Jansen-Olesen, Jes Olesen, Sarah Louise Christensen   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Intermedin Is a Calcitonin/Calcitonin Gene-related Peptide Family Peptide Acting through the Calcitonin Receptor-like Receptor/Receptor Activity-modifying Protein Receptor Complexes [PDF]

Journal of Biological Chemistry, 2004
Calcitonin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique group of peptide hormones important for homeostasis in diverse tissues. Calcitonin is essential for calcium balance, whereas CGRP and ADM are important for neurotransmission and cardiovascular and respiratory regulation.
Jaesook, Roh, Chia Lin, Chang, Alka, Bhalla, Cynthia, Klein, Sheau Yu Teddy, Hsu   +4 more
openaire   +2 more sources

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source