Results 11 to 20 of about 25,784 (209)
CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. [PDF]
PLoS ONE, 2012 BACKGROUND: Leukocyte migration is essential for effective host defense against invading pathogens and during immune homeostasis. A hallmark of the regulation of this process is the presentation of chemokines in gradients stimulating leukocyte chemotaxis
Silvia Volpe +5 more
doaj +1 more source
Phosphorylation of filamin A regulates chemokine receptor CCR2 recycling [PDF]
Journal of Cell Science, 2017 ABSTRACT Proper endosomal trafficking of ligand-activated G-protein-coupled receptors (GPCRs) is essential to spatiotemporally tune their physiological responses. For the monocyte chemoattractant receptor 2 (CCR2B; one of two isoforms encoded by CCR2), endocytic recycling is important to sustain monocyte migration, whereas filamin A ...
Pons, M. +8 more
openaire +4 more sources
Anterograde Trafficking of CXCR4 and CCR2 Receptors in a Prostate Cancer Cell Line
Cellular Physiology and Biochemistry, 2013 Background: Most prostate cancer-related deaths result from metastasis. CXCR4 and CCR2 are known to govern cellular processes resulting in cell migration, proliferation and survival.
Kelsie Gillies +3 more
doaj +1 more source
Journal of Neuroinflammation, 2018 Background A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing ...
Karli Montague +3 more
doaj +1 more source
Frontiers in Immunology, 2023 Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up ...
Gregory P. Takacs +7 more
doaj +1 more source
HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks [PDF]
FEMS Immunology & Medical Microbiology, 2000 The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5Delta32 allele among the HIV-negative subjects was 0.052, while it was approximately two-fold lower among the seropositives, suggesting that the heterozygous genotype confers a ...
A, Papa +7 more
openaire +3 more sources
Analysis of CCR2 splice variant expression patterns and functional properties
Cell & Bioscience, 2022 Background C–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells, including monocytes, macrophages, and activated T cells, and mediates cell migration toward MCP-1 in ...
Hee-Kyung Park +8 more
doaj +1 more source
Selective loss of chemokine receptor expression on leukocytes after cell isolation.
PLoS ONE, 2012 Chemokine receptors are distinctively exposed on cells to characterize their migration pattern. However, little is known about factors that may regulate their expression. To determine the optimal conditions for an accurate analysis of chemokine receptors,
Juan C Nieto +5 more
doaj +1 more source
Frontiers in Immunology, 2020 Clinical management of neuropathic pain is unsatisfactory, mainly due to its resistance to the effects of available analgesics, including opioids. Converging evidence indicates the functional interactions between chemokine and opioid receptors and their ...
Klaudia Kwiatkowski +5 more
doaj +1 more source
Localized CCR2 Activation in the Bone Marrow Niche Mobilizes Monocytes by Desensitizing CXCR4. [PDF]
PLoS ONE, 2015 Inflammatory (classical) monocytes residing in the bone marrow must enter the bloodstream in order to combat microbe infection. These monocytes express high levels of CCR2, a chemokine receptor whose activation is required for them to exit the bone ...
Hosung Jung +3 more
doaj +1 more source