Phosphorylation of filamin A regulates chemokine receptor CCR2 recycling [PDF]
Journal of Cell Science, 2017 ABSTRACT Proper endosomal trafficking of ligand-activated G-protein-coupled receptors (GPCRs) is essential to spatiotemporally tune their physiological responses. For the monocyte chemoattractant receptor 2 (CCR2B; one of two isoforms encoded by CCR2), endocytic recycling is important to sustain monocyte migration, whereas filamin A ...
Pons, M. +8 more
openaire +4 more sources
The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
core +1 more source
Journal of Neuroinflammation, 2018 Background A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing ...
Karli Montague +3 more
doaj +1 more source
Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]
, 2006 Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer +108 more
core +1 more source
HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks [PDF]
FEMS Immunology & Medical Microbiology, 2000 The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5Delta32 allele among the HIV-negative subjects was 0.052, while it was approximately two-fold lower among the seropositives, suggesting that the heterozygous genotype confers a ...
A, Papa +7 more
openaire +3 more sources
Frontiers in Immunology, 2023 Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized in part by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up ...
Gregory P. Takacs +7 more
doaj +1 more source
Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]
, 2003 To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim +5 more
core +1 more source
Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis [PDF]
, 2012 Current macrophage phenotype classifications are based on distinct in vitro culture conditions that do not adequately mirror complex tissue environments.
Weidenbusch, Marc, Anders, Hans-Joachim
core +3 more sources
Selective loss of chemokine receptor expression on leukocytes after cell isolation.
PLoS ONE, 2012 Chemokine receptors are distinctively exposed on cells to characterize their migration pattern. However, little is known about factors that may regulate their expression. To determine the optimal conditions for an accurate analysis of chemokine receptors,
Juan C Nieto +5 more
doaj +1 more source
Analysis of CCR2 splice variant expression patterns and functional properties
Cell & Bioscience, 2022 Background C–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells, including monocytes, macrophages, and activated T cells, and mediates cell migration toward MCP-1 in ...
Hee-Kyung Park +8 more
doaj +1 more source