Results 21 to 30 of about 25,784 (209)

The chemokine receptor CCR2 maintains plasmacytoid dendritic cell homeostasis [PDF]

Immunology Letters, 2017
Thymic dendritic cells (DC) play a role in central tolerance. Three thymic DC subtypes have been described: plasmacytoid DC (pDC) and two conventional DC (cDC), CD8α+ Sirpα- DC and Sirpα+ CD8α- cDC. Both pDC and Sirpα+ cDC can take up antigen in periphery and migrate into the thymus in response to chemokine signaling via CCR9 and CCR2 respectively ...
Cédile, Oriane, Østerby Jørgensen, Line, Frank, Ida, Wlodarczyk, Agnieszka, Owens, Trevor   +4 more
openaire   +3 more sources

CCR2 Receptor Ligands Inhibit Cav3.2 T-Type Calcium Channels [PDF]

Molecular Pharmacology, 2010
Monocyte chemoattractant protein-1 (MCP-1) is a cytokine known to be involved in the recruitment of monocytes to sites of injury. MCP-1 activates the chemokine (C-C motif) receptor 2 (CCR2), a seven-transmembrane helix G protein-coupled receptor that has been implicated in inflammatory pain responses.
Haitao, You, Christophe, Altier, Gerald W, Zamponi   +2 more
openaire   +2 more sources

Differential expression of chemokine receptors on monocytes in TB and HIV S

Heliyon, 2023
In the present study, we defined multiple chemokine receptors expressed by classical, intermediate and non-classical monocyte subsets in TB, HIV and TB/HIV co-infection and associate it with the perturbation of monocyte subsets due to the diseases ...
Wegene Tamene, Vincent C. Marconi, Meseret Abebe, Liya Wassie, Yohannes Belay, Amha Kebede, Ulrich Sack, Rawleigh Howe   +7 more
doaj   +1 more source

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis [PDF]

Proceedings of the National Academy of Sciences, 2012
Osteoarthritis is one of the leading causes of chronic pain, but almost nothing is known about the mechanisms and molecules that mediate osteoarthritis-associated joint pain. Consequently, treatment options remain inadequate and joint replacement is often inevitable.
Rachel E, Miller, Phuong B, Tran, Rosalina, Das, Nayereh, Ghoreishi-Haack, Dongjun, Ren, Richard J, Miller, Anne-Marie, Malfait   +6 more
openaire   +2 more sources

α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation

Pharmacological Research, 2023
We reported previously that α1-adrenoceptor (α1-AR) ligands inhibit chemokine receptor (CR) heteromerization partners of α1B/D-AR. The underlying mechanisms are unknown and in vivo evidence for such effects is missing.
Xianlong Gao, Garrett A. Enten, Michelle Y. McGee, McWayne Weche, Matthias Majetschak   +4 more
doaj   +1 more source

Monocyte populations are involved in the pathogenesis of experimental epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
Monocytes play a significant role in the pathogenesis of most inflammatory diseases, including autoimmune diseases. Herein, different subpopulations of monocytes often play differential, partially antagonistic roles, in the regulation of tissue ...
Reza Akbarzadeh, Reza Akbarzadeh, Christianna Czyz, Sarah-Yasmin Thomsen, Paul Schilf, Sripriya Murthy, Christian D. Sadik, Peter König   +7 more
doaj   +1 more source

CCR2 regulates the uptake of bone marrow-derived fibroblasts in renal fibrosis. [PDF]

PLoS ONE, 2013
Recent studies have shown that bone marrow-derived fibroblasts contribute significantly to the pathogenesis of renal fibrosis. However, the molecular mechanisms underlying the recruitment of bone marrow-derived fibroblasts into the kidney are ...
Yunfeng Xia, Mark L Entman, Yanlin Wang
doaj   +1 more source

CCR2 (chemokine (C-C motif) receptor 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on CCR2 (chemokine (C-C motif) receptor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease [PDF]

Frontiers in Immunology, 2022
Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to ...
Shaoping She, Liying Ren, Pu Chen, Mingyang Wang, Dongbo Chen, Ying Wang, Hongsong Chen   +6 more
openaire   +3 more sources

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source