Results 31 to 40 of about 25,784 (209)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni

Memorias do Instituto Oswaldo Cruz, 2010
The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis.
Denise Silveira-Lemos, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Adriano Luiz Souza-Soares, Pollyanna Castro-Silva, Matheus Fernandes Costa-Silva, Pedro Henrique Gazzinelli Guimarães, Helena Barbosa Ferraz, Lúcia Alves Oliveira-Fraga, Mauro Martins Teixeira, Rodrigo Corrêa-Oliveira   +10 more
doaj   +1 more source

Increased Intrathecal Chemokine Receptor CCR2 Expression in Multiple Sclerosis

Biomarker Insights, 2007
Expression of CCR2, CXCR3 and CCR4 on CD4+T or CD8+T cells in blood and cerebrospinal fluid (CSF) for multiple sclerosis (MS) was measured by 3-color flow cytometry, and compared to blood from healthy controls and CSF from patients with other inflammatory neurological diseases (INDs).
Hideto Nakajima, Masakazu Sugino, Fumiharu Kimura, Toshiaki Hanafusa, Toshiyuki Ikemoto, Akira Shimizu   +5 more
openaire   +3 more sources

Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury

American Journal of Physiology-Renal Physiology, 2011
Monocyte/macrophage recruitment correlates strongly with the progression of renal impairment in diabetic nephropathy (DN). C-C chemokine receptor (CCR)2 regulates monocyte/macrophage migration into injured tissues. However, the direct role of CCR2-mediated monocyte/macrophage recruitment in diabetic kidney disease remains unclear.
Alaa S, Awad, Gilbert R, Kinsey, Konstantine, Khutsishvili, Ting, Gao, W Kline, Bolton, Mark D, Okusa   +5 more
openaire   +3 more sources

Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE

Journal of Neuroinflammation, 2007
Background The CC chemokine receptors CCR1, CCR2 and CCR5 are critical for the recruitment of mononuclear phagocytes to the central nervous system (CNS) in multiple sclerosis (MS) and other neuroinflammatory diseases.
Ericsson-Dahlstrand Anders, Olsson Tomas, Nilsson Maria, Wallström Erik, Lassmann Hans, Berg Anna-Lena, Eltayeb Sana, Sunnemark Dan   +7 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy

Scientific Reports, 2017
CC Chemokine Receptor 2 (CCR2) and its endogenous ligand CCL2 are involved in a number of diseases, including atherosclerosis. Several CCR2 antagonists have been developed as potential therapeutic agents, however their in vivo clinical efficacy was ...
Ilze Bot, Natalia V. Ortiz Zacarías, Wilhelmus E. A. de Witte, Henk de Vries, Peter J. van Santbrink, Daniël van der Velden, Mara J. Kröner, Dirk-Jan van der Berg, Dean Stamos, Elizabeth C. M. de Lange, Johan Kuiper, Adriaan P. IJzerman, Laura H. Heitman   +12 more
doaj   +1 more source

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5

, 2023
AbstractBy driving monocyte chemotaxis, the chemokine receptor CCR2 shapes inflammatory responses and the formation of tumor microenvironments. This makes it a promising target in inflammation and immuno-oncology; however, despite extensive efforts, there are no FDA-approved CCR2-targeting therapeutics.
John R.D. Dawson, Grant M. Wadman, Penglie Zhang, Andrew Tebben, Percy H. Carter, Siyi Gu, Thomas Shroka, Leire Borrega-Roman, Catherina L. Salanga, Tracy M. Handel, Irina Kufareva   +10 more
openaire   +2 more sources

Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction [PDF]

Genes & Immunity, 2001
Our objective was to examine the association between myocardial infarction (MI) and two DNA-polymorphisms at the proinflammatory chemokine receptors CCR2 (I64V) and CCR5 (32 bp deletion, (Delta)ccr5), defining if these polymorphisms influence the age for the onset of MI. A total of 214 patients with an age at the first MI episode
P, González, R, Alvarez, A, Batalla, J R, Reguero, V, Alvarez, A, Astudillo, G I, Cubero, A, Cortina, E, Coto   +8 more
openaire   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source