Results 31 to 40 of about 43,606 (294)

α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation

Pharmacological Research, 2023
We reported previously that α1-adrenoceptor (α1-AR) ligands inhibit chemokine receptor (CR) heteromerization partners of α1B/D-AR. The underlying mechanisms are unknown and in vivo evidence for such effects is missing.
Xianlong Gao, Garrett A. Enten, Michelle Y. McGee, McWayne Weche, Matthias Majetschak   +4 more
doaj   +1 more source

CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.

PLoS ONE, 2012
BackgroundLeukocyte migration is essential for effective host defense against invading pathogens and during immune homeostasis. A hallmark of the regulation of this process is the presentation of chemokines in gradients stimulating leukocyte chemotaxis ...
Silvia Volpe, Elisabetta Cameroni, Barbara Moepps, Sylvia Thelen, Tiziana Apuzzo, Marcus Thelen   +5 more
doaj   +1 more source

Monocyte populations are involved in the pathogenesis of experimental epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
Monocytes play a significant role in the pathogenesis of most inflammatory diseases, including autoimmune diseases. Herein, different subpopulations of monocytes often play differential, partially antagonistic roles, in the regulation of tissue ...
Reza Akbarzadeh, Reza Akbarzadeh, Christianna Czyz, Sarah-Yasmin Thomsen, Paul Schilf, Sripriya Murthy, Christian D. Sadik, Peter König   +7 more
doaj   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

CCR2 regulates the uptake of bone marrow-derived fibroblasts in renal fibrosis. [PDF]

PLoS ONE, 2013
Recent studies have shown that bone marrow-derived fibroblasts contribute significantly to the pathogenesis of renal fibrosis. However, the molecular mechanisms underlying the recruitment of bone marrow-derived fibroblasts into the kidney are ...
Yunfeng Xia, Mark L Entman, Yanlin Wang
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

CCR2 (chemokine (C-C motif) receptor 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on CCR2 (chemokine (C-C motif) receptor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source

Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease [PDF]

Frontiers in Immunology, 2022
Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to ...
Shaoping She, Liying Ren, Pu Chen, Mingyang Wang, Dongbo Chen, Ying Wang, Hongsong Chen   +6 more
openaire   +3 more sources

Organ-specific features of natural killer cells. [PDF]

, 2011
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical.
La Cava, Antonio, Ljunggren, Hans-Gustaf, Shi, Fu-Dong, Van Kaer, Luc   +3 more
core   +1 more source