Results 61 to 70 of about 7,919 (172)

The chemokine receptor CCR3 participates in tissue remodeling during atopic skin inflammation [PDF]

Journal of Dermatological Science, 2013
Recent studies provided insights into the recruitment and activation pathways of leukocytes in atopic dermatitis, however, the underlying mechanisms of tissue remodeling in atopic skin inflammation remain elusive.To identify chemokine-mediated communication pathways regulating tissue remodeling during atopic skin inflammation.Analysis of the chemokine ...
Krisztian, Gaspar, Gabriela, Kukova, Erich, Bunemann, Bettina Alexandra, Buhren, Eniko, Sonkoly, Attila Gabor, Szollosi, Anja, Muller, Terhi, Savinko, Antti I, Lauerma, Harri, Alenius, Lajos, Kemeny, Marie-Caroline, Dieu-Nosjean, Sonja, Stander, Jens W, Fischer, Thomas, Ruzicka, Albert, Zlotnik, Andrea, Szegedi, Bernhard, Homey   +17 more
openaire   +2 more sources

Bone Marrow Failure Model Mimics Aplastic Anemia Patients: Single‐Cell Landscape of Immune Response Reveals Novel Mechanisms of Immune Imbalance in AA

Cancer Medicine, Volume 15, Issue 6, June 2026.
Single‐cell RNA‐seq is used in a mouse model of immune‐mediated bone marrow failure. Approach to platelets and mitochondrial data. Analysis of various immune cell landscapes, interactions and driving factors in BMF, involving platelets, CD4+ T Cells, CD8+ T Cells, macrophages, and mitochondrial energy metabolism pathways.
Shuai Tan, Fang Fang, Jing Sun, Yumeng Li, Yaochi Chen, Wanling Sun   +5 more
wiley   +1 more source

Chemokine Receptor CCR3 Function Is Highly Dependent on Local pH and Ionic Strength [PDF]

Journal of Biological Chemistry, 1997
The CC chemokine receptor 3 (CCR3) plays an important role in the regulation of the migration of eosinophils, a leukocyte population involved in many inflammatory pathologies including asthma. CCR3 binds to the CC chemokine eotaxin, a promigratory cytokine originally isolated as the key component in a model of eosinophil-induced airway inflammation. We
D J, Dairaghi, E R, Oldham, K B, Bacon, T J, Schall   +3 more
openaire   +2 more sources

Artificial Sweeteners and Autoimmune Diseases: Insights From Integrative Bioinformatics and Mendelian Randomization

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This study provides a novel molecular perspective on the role of AS in ADs development. We identified a positive association between artificially sweetened cereal intake and ADs risk and revealed multiple pathogenic mechanisms involving apoptosis, inflammatory signaling, immune activation, and gut microbiota dysbiosis.
Yupei Liu, Jizhen Huang, Xue Hu, Shan Tian, Jiao Li, Shiyun Tan, Weiguo Dong   +6 more
wiley   +1 more source

High Radiological Severity in CRSwNP Is Associated With a Mixed Type 2/Type 3 Epithelial Inflammatory Signature

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
This study demonstrates that high radiological severity in patients with CRSwNP is uniquely characterized by a mixed Type 2 and Type 3 epithelial inflammatory signature. These findings suggest that severe disease involves a complex immune endotype, providing new insights into precision therapeutic strategies for refractory CRSwNP.
Guangfu Xu, Ming Tian, Kanghua Wang, Yunping Fan, Yueqi Sun, Chang Liu   +5 more
wiley   +1 more source

Chemokine receptor CCR3 is important for migration of mast cells in neurofibroma

Dermatologica Sinica, 2010
AbstractBackgroundNeurofibroma consists of abundant extracellular matrix and many types of cells, including Schwann cells (SCs), mast cells (MCs), fibroblasts and endothelial cells. As SCs have been found to be the cell of origin for neurofibroma, how MCs may migrate into the tumor has not been fully clarified.
Wei-Chun Tai, Sin-Ting Wang, Chieh-Shan Wu, Tze-Yi Lin, Meng-Tse Wu   +4 more
openaire   +2 more sources

Plasmodium yoelii 17XL infection up-regulates RANTES, CCR1, CCR3 and CCR5 expression, and induces ultrastructural changes in the cerebellum

Malaria Journal, 2005
Background Malaria afflicts 300–500 million people causing over 1 million deaths globally per year. The immunopathogenesis of malaria is mediated partly by co mplex cellular and immunomodulator interactions involving co-regulators such as cytokines and ...
Singh Shailesh, Olver Christine S, Adjei Andrew A, Irune Ikovwaiza, Armah Henry B, Sarfo Bismark Y, Lillard James W, Stiles Jonathan K   +7 more
doaj   +1 more source

Single‐Cell Omics Analysis of Human Basophils Reveals Two Transcriptionally Distinct Populations

Allergy, Volume 81, Issue 6, Page 2059-2068, June 2026.
Integrated single‐cell transcriptomics and large‐scale immunophenotyping reveal the molecular landscape of human basophils. Circulating basophils comprise two transcriptionally distinct populations. A user‐friendly web resource enables interactive exploration of the generated data.
Sofia Papavasileiou, Jiezhen Mo, Daryl Boey, Chenyan Wu, Magnus Tronstad, Lucille Margerie, Remi‐André Olsen, Jörg A. Bachmann, Jing Hui Low, Jocelyn Ong, Lars Heede Blom, Anand Kumar Andiappan, Gunnar Nilsson, Joakim S. Dahlin   +13 more
wiley   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, Volume 13, Issue 19, 2 April 2026.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source