Results 81 to 90 of about 7,919 (172)

XMRV: usage of receptors and potential co-receptors

Virology Journal, 2011
Background XMRV is a gammaretrovirus first identified in prostate tissues of Prostate Cancer (PC) patients and later in the blood cells of patients with Chronic Fatigue Syndrome (CFS).
Gaddam Durga, Wood Owen, Tang Shixing, Ravichandran Veerasamy, Ragupathy Viswanath, Devadas Krishnakumar, Haleyur Giri Setty Mohan Kumar, Lee Sherwin, Hewlett Indira K   +8 more
doaj   +1 more source

Prevalence and CCR3-T51C genotype–phenotype correlation of bronchial asthma among basic education school children: an observational study

Egyptian Pediatric Association Gazette
Background Bronchial asthma (BA) is a chronic inflammatory disorder identified by different endotypes and phenotypes. Chemokine receptor 3 (CCR3) is one of the essential chemokine receptors that have a crucial role in asthma development by activating the
Magdy Zedan, Mona Elwassefy, Ismail El Zareif, Hossam ElTahan, Yahya Wahba   +4 more
doaj   +1 more source

CCL28 modulates neutrophil responses during infection with mucosal pathogens

eLife
The chemokine CCL28 is highly expressed in mucosal tissues, but its role during infection is not well understood. Here, we show that CCL28 promotes neutrophil accumulation in the gut of mice infected with Salmonella and in the lung of mice infected with ...
Gregory T Walker, Araceli Perez-Lopez, Steven Silva, Michael H Lee, Elisabet Bjånes, Nicholas Dillon, Stephanie L Brandt, Romana R Gerner, Karine Melchior, Grant J Norton, Felix A Argueta, Frenchesca Dela Pena, Lauren Park, Victor A Sosa-Hernandez, Rodrigo Cervantes-Diaz, Sandra Romero-Ramirez, Monica Cartelle Gestal, Jose L Maravillas-Montero, Sean-Paul Nuccio, Victor Nizet, Manuela Raffatellu   +20 more
doaj   +1 more source

Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment

Mediators of Inflammation, 2015
Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea. Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. We compared gene and
Sezin Günaltay, Ashok Kumar Kumawat, Nils Nyhlin, Johan Bohr, Curt Tysk, Olof Hultgren, Elisabeth Hultgren Hörnquist   +6 more
doaj   +1 more source

What can we learn from molecular dynamics simulations for GPCR drug design?

Computational and Structural Biotechnology Journal, 2015
Recent years have seen a tremendous progress in the elucidation of experimental structural information for G-protein coupled receptors (GPCRs). Although for the vast majority of pharmaceutically relevant GPCRs structural information is still accessible ...
Christofer S. Tautermann, Daniel Seeliger, Jan M. Kriegl   +2 more
doaj   +1 more source

Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica

BMC Neurology, 2010
Background The role of different chemokine receptors in the pathogenesis of multiple sclerosis (MS) has been extensively investigated; however, little is known about the difference in the role of chemokine receptors between the pathogenesis of ...
Nomura Fumio, Masuda Saeko, Hayakawa Sei, Mori Masahiro, Uzawa Akiyuki, Kuwabara Satoshi   +5 more
doaj   +1 more source

The Impact of Three Genospecies of Borrelia on Expression of Genes Associated with Chemokines and Their Receptors in Normal Human Dermal Fibroblasts

European Journal of Inflammation, 2014
An important role in pathomechanism of Lyme disease is played by the ability of spirochetes to spread within tissues, and to adhere (to platelets, erythrocytes and vascular epithelium).
J. Gola, S. Dudek, K. Jasik, K. Solarz, M. Muc-Wierzgoń, T. Kokot, E. Nowakowska-Zajdel, E. Ziółko, E. Fatyga, U. Mazurek   +9 more
doaj   +1 more source

Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population

Brazilian Journal of Infectious Diseases
Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including
Patrícia Munerato, Maria Lúcia Azevedo, Maria Cecília Araripe Sucupira, Regina Pardini, Gedson Humberto Novaes Pinto, Márcia Catroxo, Inara Espinelli Souza, Ricardo Sobhie Diaz   +7 more
doaj   +1 more source

Blockade of the CCR3 receptor reduces neutrophil recruitment to the lung during acute inflammation

Journal of Leukocyte Biology
Abstract Neutrophils represent one of the host's first lines of defense against invading pathogens. However, an aberrant activation can cause damage to the host. In the case of respiratory infections with viral or bacterial pathogens, one of the most common complications is the development of acute respiratory distress syndrome, in which
Fatima Lopez-Leal, Tecilli Cabellos-Avelar, Diego A Correa-Becerril, Brenda Juarez-Macias, Rodrigo Cervantes-Diaz, Raul F Reyes-Huerta, Guillermo Juarez-Vega, Daniel Gutierrez-Castaneda, Tannya Karen Castro-Jimenez, Jose Bustos-Arriaga, Jose Luis Maravillas-Montero, Araceli Perez-Lopez   +11 more
openaire   +2 more sources

A Small Molecule Antagonist of Chemokine Receptors CCR1 and CCR3 [PDF]

Journal of Biological Chemistry, 2000
Ian Sabroe, Michael J. Peck, Berend Jan Van Keulen, Annelies Jorritsma, Graham Simmons, Paul R. Clapham, Timothy J. Williams, James E. Pease   +7 more
openaire   +1 more source