Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targeting. [PDF]
PLoS ONE, 2013 AIMS: To compare the constitutive and agonist-dependent endosomal trafficking of α(1A)- and α(1B)-adrenoceptors (ARs) and to establish if the internalization pattern determines the signaling pathways of each subtype. METHODS: Using CypHer5 technology and
Vanessa Segura +8 more
doaj +11 more sources
Anti-inflammatory activity of Acanthospermum australe: Insights from network pharmacology, chemical analysis, and in vitro assays. [PDF]
PLoS ONEInflammation plays a crucial role in homeostasis and defense responses; however, exaggerated and chronic inflammation contribute to the development and worsening of various diseases. Acanthospermum australe (Loefl.) Kuntze (A.
Andrea Salinas +6 more
doaj +2 more sources
The Binding of Concanavalin A to the Surface of Intact and Denuded Sea Urchin Eggs Affects the Fertilization Process by Altering the Structural Dynamics of Actin Filaments [PDF]
CellsSea urchin eggs are surrounded by a network of extracellular matrix, consisting of the jelly coat (JC) and vitelline layer (VL). While the voluminous JC evokes acrosomal reaction in the approaching sperm, the tight VL ensheathing the plasma membrane of ...
Nunzia Limatola +4 more
doaj +2 more sources
The scramblase anoctamin 9 controls the immune response in lymphocytes [PDF]
Cellular and Molecular Life SciencesWe previously reported a loss of T cell activation following knockdown of the phospholipid scramblase and ion channel ANO9 (TMEM16J) in human Jurkat lymphocytes.
Rainer Schreiber +2 more
doaj +2 more sources
Concanavalin A receptors, immunoglobulins, and theta antigen of the lymphocyte surface. Interactions with concanavalin A and with Cytoplasmic structures. [PDF]
Journal of Cell Biology, 1975 The effect of concanavalin A (Con A) on the capping of mouse lymphocyte surface immunoglobulin (surface Ig), cross-linked by rabbit anti-mouse Ig antibody, and on the capping of mouse thymocyte theta antigen, cross-linked by anti-theta alloantibody and rabbit anti-mouse Ig antibody, has been studied by immunofluorescence, using fluorescein conjugated ...
exaly +3 more sources
Lectin-induced alterations of the interaction of insulin and insulin-like growth factor 1 receptors with their ligands [PDF]
Journal of the Serbian Chemical Society, 2008 In order to study whether the carbohydrate moieties of the human placental IGF-I receptor (IGF1R), IGF-II receptor (IGF2R) and insulin receptors (IRs) play a role in ligand binding, solubilised cell membrane preparations were incubated with 125I-labelled
Masnikosa Romana +2 more
doaj +3 more sources
Structural Arrangement Produced by Concanavalin A Binding to Homomeric GluK2 Receptors
Membranes, 2021 Kainate receptors are members of the ionotropic glutamate receptor family. They form cation-specific transmembrane channels upon binding glutamate that desensitize in the continued presence of agonists.
Cuauhtemoc U. Gonzalez +3 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Kagocel is a synthetic carboxymethylcellulose derivative copolymerized with gossypol. Clinical data evidence its safety and efficiency for the treatment of flu and other viral infections via enhancement of interferon production.
Alexander A. Andreev-Andrievskiy +11 more
doaj +1 more source
Lymphocyte receptors for concanavalin A in Hodgkin disease [PDF]
Blood, 1978 The number of lymphocytes with mobile receptors for concanavalin A (Con A) on their surface membrane (forming visible caps after the addition of fluorescein-conjugated Con A) was determined in the peripheral blood of 53 patients with Hodgkin disease.
A C, Aisenberg, S, Weitzman, B, Wilkes
openaire +3 more sources
Unrestrained Gαi2 Signaling Disrupts Neutrophil Trafficking, Aging, and Clearance
Frontiers in Immunology, 2021 Neutrophil trafficking, homeostatic and pathogen elicited, depends upon chemoattractant receptors triggering heterotrimeric G-protein Gαiβγ signaling, whose magnitude and kinetics are governed by RGS protein/Gαi interactions. RGS proteins typically limit
Serena Li-Sue Yan +6 more
doaj +1 more source