Results 11 to 20 of about 14,486 (179)
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Cooperative Binding of Concanavalin A to Thymocytes at 4oC and Micro-redistribution of Concanavalin A Receptors [PDF]
European Journal of Biochemistry, 1976 The mode of binding of 125I-labelled concanavalin A and succinyl-concanavalin A to rat thymocytes at 4 degrees C was investigated. Simultaneously, the free binding sites of the cell-bound lectin molecules were quantified by horseradish peroxidase binding. Concanavalin A showed cooperative binding while succinyl-concanavalin A did not.
M, Bornens, E, Karsenti, S, Avrameas
openaire +2 more sources
European Psychiatry, 2022 Introduction GABAa-receptors proved to be the molecular targets of ethanol on immune and nervous cells, potentiating alcohol influence. ortho-Fluoro-benzonal is known to be a circular urea derivative and an artificial ligand of GABA/BD-receptor and thus
E. Markova, I. Savkin, Т. Shushpanova
doaj +1 more source
Cell Communication and Signaling, 2022 Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular ...
Huldani Huldani +10 more
doaj +1 more source
Carbohydrate mediated drug delivery: Synthesis and characterization of new lipid-conjugates
Data in Brief, 2015 A new synthetic methodology for cationic glycolipids using p-aminophenyl-α-d-mannopyranoside (PAPM), p-aminophenyl-α-d-galactopyranoside (PAPG) was developed.
Moghis U. Ahmad +5 more
doaj +1 more source
Journal of Pharmacological Sciences, 2006 .: This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 – 1000 nmol/paw) coadministrated with
Sonja Vučković +5 more
doaj +1 more source
Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol. [PDF]
PLoS ONE, 2011 Myeloid-derived suppressor cells (MDSCs) are getting increased attention as one of the main regulatory cells of the immune system. They are induced at sites of inflammation and can potently suppress T cell functions.
Venkatesh L Hegde +2 more
doaj +1 more source
Molecular Pain, 2012 Background Proopiomelanocortin (POMC)-derived beta-endorphin1-31 from immune cells can inhibit inflammatory pain. Here we investigated cytokine signaling pathways regulating POMC gene expression and beta-endorphin production in lymphocytes to augment ...
Busch-Dienstfertig Melanie +4 more
doaj +1 more source
Hemolytic activity of Trichomonas vaginalis and Tritrichomonas foetus
Memorias do Instituto Oswaldo Cruz, 1996 The hemolytic activity of live isolates and clones of Trichomonas vaginalis and Tritrichomonas foetus was investigated. The isolates were tested against human erythrocytes. No hemolytic activity was detected by the isolates of T. foetus.
Geraldo A De Carli +4 more
doaj +1 more source
Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targeting. [PDF]
PLoS ONE, 2013 AIMS: To compare the constitutive and agonist-dependent endosomal trafficking of α(1A)- and α(1B)-adrenoceptors (ARs) and to establish if the internalization pattern determines the signaling pathways of each subtype. METHODS: Using CypHer5 technology and
Vanessa Segura +8 more
doaj +1 more source