Colorectal Cancer: The Contribution of CXCL12 and Its Receptors CXCR4 and CXCR7. [PDF]
Cancers (Basel), 2022 Simple Summary Many signaling pathways are involved in cancer progression, and among these pathways, the CXCL12 axis and its two receptors CXCR4 and CXCR7 are well described for many cancers.
Goïta AA, Guenot D.
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Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes. [PDF]
PLoS ONE, 2010 The entry of human immunodeficiency virus (HIV-1) into host cells involves the interaction of the viral exterior envelope glycoprotein, gp120, and receptors on the target cell. The HIV-1 receptors are CD4 and one of two chemokine receptors, CCR5 or CXCR4.
Mikhail A Zhukovsky +6 more
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Chemokine Receptors CXCR4 and CXCR7 are Associated with Tumor Aggressiveness and Prognosis in Extramammary Paget Disease. [PDF]
J Cancer, 2017 Chemokines are involved in many aspects of oncogenesis, including regulation of cancer cell growth, dissemination and host-tumor response. However, the potential of the chemokine receptors, CXCR4 and CXCR7, in serving as biomarkers in extramammary Paget ...
Chang K +8 more
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Consequences of ChemR23 heteromerization with the chemokine receptors CXCR4 and CCR7. [PDF]
PLoS ONE, 2013 Recent studies have shown that heteromerization of the chemokine receptors CCR2, CCR5 and CXCR4 is associated to negative binding cooperativity. In the present study, we build on these previous results, and investigate the consequences of chemokine ...
Cédric de Poorter +4 more
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Dual targeting of the chemokine receptors CXCR4 and ACKR3 with novel engineered chemokines. [PDF]
J Biol Chem, 2015 Background: Chemokine receptors CXCR4 and ACKR3 are deregulated in many diseases. Results: Potent modulators of CXCR4 and ACKR3 were engineered by phage display of the chemokine CXCL12.
Hanes MS +6 more
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Role and implications of the CXCL12/CXCR4/CXCR7 axis in atherosclerosis: still a debate
Annals of Medicine, 2021 Atherosclerosis is one of the leading causes of mortality and morbidity worldwide. Chemokines and their receptors are implicated in the pathogenesis of atherosclerosis.
Hussam A. S. Murad +2 more
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Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells. [PDF]
PLoS ONE, 2013 Glioblastoma (GBM) is the most common primary brain tumor in adults. The poor prognosis and minimally successful treatments of these tumors indicates a need to identify new therapeutic targets. Therapy resistance of GBMs is attributed to heterogeneity of
Che Liu +6 more
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Inhibition of SDF-1 receptors CXCR4 and CXCR7 attenuates acute pulmonary inflammation via the adenosine A2B-receptor on blood cells. [PDF]
Cell Death Dis, 2017 Acute pulmonary inflammation is characterized by migration of polymorphonuclear neutrophils into the different compartments of the lung. Recent studies showed evidence that the chemokine stromal cell-derived factor (SDF)-1 and its receptors CXCR4 and ...
Konrad FM +4 more
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The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases
Frontiers in Endocrinology, 2019 Chemokine receptors are members of the G protein-coupled receptor superfamily. These receptors are intimately involved in cell movement, and thus play a critical role in several physiological and pathological situations that require the precise ...
Eva M. García-Cuesta +5 more
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The CXCR4/CXCR7/CXCL12 Axis Is Involved in a Secondary but Complex Control of Neuroblastoma Metastatic Cell Homing. [PDF]
PLoS ONE, 2015 Neuroblastoma (NB) is one of the most deadly solid tumors of the young child, for which new efficient and targeted therapies are strongly needed. The CXCR4/CXCR7/CXCL12 chemokine axis has been involved in the progression and organ-specific dissemination ...
Annick Mühlethaler-Mottet +8 more
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