Results 11 to 20 of about 2,396,893 (309)

Antibodies Targeting Chemokine Receptors CXCR4 and ACKR3 [PDF]

Molecular Pharmacology, 2019
Dysregulation of the chemokine system is implicated in a number of autoimmune and inflammatory diseases, as well as cancer. Modulation of chemokine receptor function is a very promising approach for therapeutic intervention.
V. Bobkov, Marta Arimont, Aurelien M. Zarca, Timo W. M. De Groof, Bas van der Woning, H. de Haard, M. Smit   +6 more
semanticscholar   +5 more sources

Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor

Frontiers in Molecular Biosciences, 2022
Chemokine receptors are key G-protein-coupled receptors (GPCRs) that control cell migration in immune system responses, development of cardiovascular and central nervous systems, and numerous diseases. In particular, the CXCR4 chemokine receptor promotes
Shristi Pawnikar, Yinglong Miao
doaj   +4 more sources

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers [PDF]

Communications Biology
Chemokine receptors CXCR4 and ACKR3 are involved in multiple physiological and pathological processes. In overexpression systems, CXCR4 and ACKR3 form oligomers that are important for chemokine recognition and signaling.
Joyce Heuninck, Vladimir Bobkov, Claire M. Grison, Amos Fumagalli, Mathias Lescuyer, Omolade Otun, Cherine Bechara, Laurent Lamarque, Eric Trinquet, Françoise Bachelerie, Philippe Marin, Bernard Mouillac, Sébastien Granier, Bas van der Woning, Hans de Haard, Martine J. Smit, Raimond Heukers, Thierry Durroux   +17 more
doaj   +2 more sources

Regulation of Human Chemokine Receptors CXCR4 [PDF]

Journal of Biological Chemistry, 1997
Members of the chemokine receptor family CCR5 and CXCR4 have recently been shown to be involved in the entry of human immunodeficiency virus (HIV) into target cells. Here, we investigated the regulation of CXCR4 in rat basophilic leukemia cells (RBL-2H3)
B. Haribabu, R. Richardson, I. Fisher, S. Sozzani, S. Peiper, R. Horuk, H. Ali, R. Snyderman   +7 more
semanticscholar   +2 more sources

CXCR4 mediated recognition of HIV envelope spike and inhibition by CXCL12 [PDF]

Nature Communications
CCR5 and CXCR4 both act as HIV co-receptors, though CXCR4 is less explored. CXCR4 binds the chemokine CXCL12 to regulate cellular processes and mediate HIV entry, a process that CXCL12 inhibits.
Zhiying Zhang, Hongwei Zhang, Lyuqin Zheng, Shihua Chen, Shuo Du, Junyu Xiao, Dinshaw J. Patel   +6 more
doaj   +2 more sources

Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. [PDF]

, 2013
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
A Kaur, A Llano, A Yates, AN Phillips, Andrea Hegedus, Andrew Worth, B Asquith, Catherine de Lara, D Berhanu, Daniel C. Douek, DC Douek, DC Douek, DC Macallan, DC Macallan, DC Macallan, DC Macallan, DD Ho, Derek Macallan, DL Wallace, EJ Heeregrave, HC Lane, I den Braber, J Embretson, JM Brenchley, JM McCune, JV Giorgi, K Ladell, Karoliina Laamanen, L Cicin-Sain, LJ Picker, M Catalfamo, M Hellerstein, M Koot, MD Hazenberg, MK Hellerstein, MP Davenport, N Brieu, N Vrisekoop, Peter Beverley, R Busch, R Shankarappa, RJ De Boer, RJ De Boer, RM Ribeiro, RM Ribeiro, RS Veazey, SA Handley, TW Chun, V Sanchez, Yan Zhang   +49 more
core   +12 more sources

Molecular Imaging of Chemokine Receptor CXCR4 [PDF]

Theranostics, 2013
CXCR4 was found to be expressed by many different types of human cancers and its expression has been correlated with tumor aggressiveness, poor prognosis and resistance to chemotherapy. CXCR4 was also shown to contribute to metastatic seeding of organs that express its ligand CXCL12 and support the survival of these cells.
Weiss, Ido. D., Jacobson, Orit
openaire   +4 more sources

Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]

PLoS Computational Biology, 2018
Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer, Kristyna Pluhackova, Rainer A Böckmann   +2 more
doaj   +1 more source

Interactions of selected cardiovascular active natural compounds with CXCR4 and CXCR7 receptors: a molecular docking, molecular dynamics, and pharmacokinetic/toxicity prediction study

BMC Complementary Medicine and Therapies, 2022
Background The chemokine CXCL12 and its two receptors (CXCR4 and CXCR7) are involved in inflammation and hematopoietic cell trafficking. This study was designed to investigate molecular docking interactions of four popular cardiovascular-active natural ...
Hussam Aly Sayed Murad, Thamer Mohammed Ahmed Alqurashi, Mostafa Aly Hussien   +2 more
doaj   +1 more source

Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor. [PDF]

PLoS ONE, 2009
WHIM (warts, hypogammaglobulinemia, infections, and myelokatexis) syndrome is a rare immunodeficiency syndrome linked to heterozygous mutations of the chemokine receptor CXCR4 resulting in truncations of its cytoplasmic tail.
Peter J McCormick, Marta Segarra, Paola Gasperini, A Virginia Gulino, Giovanna Tosato   +4 more
doaj   +1 more source