Results 1 to 10 of about 371,200 (274)

Identification of cytokine-induced cell communications by pan-cancer meta-analysis [PDF]

PeerJ, 2023
Cancer immune responses are complex cellular processes in which cytokine–receptor interactions play central roles in cancer development and response to therapy; dysregulated cytokine–receptor communication may lead to pathological processes, including ...
Yining Liu, Min Zhao, Hong Qu
doaj   +2 more sources

Structure of the IL-27 quaternary receptor signaling complex

eLife, 2022
Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis.
Nathanael A Caveney, Caleb R Glassman, Kevin M Jude, Naotaka Tsutsumi, K Christopher Garcia   +4 more
doaj   +1 more source

In Situ Identification of Both IL-4 and IL-10 Cytokine–Receptor Interactions during Tissue Regeneration

Cells, 2023
Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process.
Krisztina Nikovics, Anne-Laure Favier, Mathilde Rocher, Céline Mayinga, Johanna Gomez, Frédérique Dufour-Gaume, Diane Riccobono   +6 more
doaj   +1 more source

Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases—RA as a role model

Inflammation and Regeneration, 2022
Recent advances in our understanding in the immune-mediated inflammatory diseases (IMID) are explored and promoted by the targeted treatment. Among these targets, cytokines and cytokine receptors have become the good candidates for the drug development ...
Tsutomu Takeuchi
doaj   +1 more source

QTY Code-designed Water-soluble Fc-fusion Cytokine Receptors Bind to their Respective Ligands

QRB Discovery, 2020
Cytokine release syndrome (CRS), or ‘cytokine storm’, is the leading side effect during chimeric antigen receptor (CAR)-T therapy that is potentially life-threatening.
Shilei Hao, David Jin, Shuguang Zhang, Rui Qing   +3 more
doaj   +1 more source

Microbial Phagocytic Receptors and Their Potential Involvement in Cytokine Induction in Macrophages

Frontiers in Immunology, 2021
Phagocytosis is an essential process for the uptake of large (>0.5 µm) particulate matter including microbes and dying cells. Specialized cells in the body perform phagocytosis which is enabled by cell surface receptors that recognize and bind target ...
Yan Lin Fu, Yan Lin Fu, Rene E. Harrison, Rene E. Harrison   +3 more
doaj   +1 more source

Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor. [PDF]

PLoS ONE, 2011
Length and intensity of signal transduction via cytokine receptors is precisely regulated. Degradation of certain cytokine receptors is mediated by the ubiquitin ligase SCF(βTrCP).
Joyce Putters, Ana C da Silva Almeida, Peter van Kerkhof, Agnes G S H van Rossum, Ana Gracanin, Ger J Strous   +5 more
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Features of changes in the expression level of TNFα receptors and the functional response of cell lines upon stimulation with various doses of cytokine

Медицинская иммунология, 2023
TNFa is a pro-inflammatory cytokine that is signaled through type 1 (TNFR1) and type 2 (TNFR2) receptors. TNFR1 normally mediates apoptosis, cell survival, and cytokine secretion, while TNFR2 selectively mediates cell survival and cytokine secretion. But
Yu. A. Lopatnikova, Yu. V. Zhukova, A. A. Alshevskaya, I. A. Obleukhova, F. D. Kireev, I. A. Belomestnova, S. V. Sennikov   +6 more
doaj   +1 more source

Multimerization strategies for efficient production and purification of highly active synthetic cytokine receptor ligands.

PLoS ONE, 2020
Cytokine signaling is transmitted by cell surface receptors which act as natural biological switches to control cellular functions such as immune reactions.
Sofie Mossner, Hoang T Phan, Saskia Triller, Jens M Moll, Udo Conrad, Jürgen Scheller   +5 more
doaj   +1 more source

Common Ɣ-chain cytokine receptors as functional phenotype markers of PD-1and TIM-3-positive T cells in multiple myeloma

Сибирский онкологический журнал, 2023
T cells expressing checkpoint receptors PD-1, TIM-3 etc., are potential targets for monoclonal antibody immunotherapy in multiple myeloma (MM). However, checkpoint expressing T cell compartment includes different subsets, and their dysregulation ...
E. V. Batorov, V. A. Aristova, G. Yu. Ushakova, S. A. Sizikova, V. V. Denisova, E. Ya. Shevela, A. A. Ostanin, E. R. Chernykh   +7 more
doaj   +1 more source