Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]
J Cell Biochem (2021) 1-8, 2020 The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv +1 more source
Distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein: a potential hint at the possibility of local iron dysregulation in COVID-19 [PDF]
Biol. Direct 15 (2020) 19, 2020 The spike glycoprotein of the SARS-CoV-2 virus, which causes COVID-19, has attracted attention for its vaccine potential and binding capacity to host cell surface receptors. Much of this research focus has centered on the ectodomain of the spike protein. The ectodomain is anchored to a transmembrane region, followed by a cytoplasmic tail.
arxiv +1 more source
Metareview-informed Explainable Cytokine Storm Detection during CAR-T cell Therapy [PDF]
arXiv, 2022 Cytokine release syndrome (CRS), also known as cytokine storm, is one of the most consequential adverse effects of chimeric antigen receptor therapies that have shown promising results in cancer treatment. When emerging, CRS could be identified by the analysis of specific cytokine and chemokine profiles that tend to exhibit similarities across patients.
arxiv
Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]
arXiv, 2022 The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv
Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta [PDF]
Arthritis Research \& Therapy, 2010, 13 (1), pp.R23.
\Transforming growth factor beta (TGF$\beta$) plays a central role in morphogenesis, growth, and cell differentiation. This cytokine is particularly important in cartilage where it regulates cell proliferation and extracellular matrix synthesis. While the action of TGF$\beta$ on chondrocyte metabolism has been extensively catalogued, the modulation of ...
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Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization [PDF]
arXiv, 2021 When genetic variants in a gene cluster are associated with a disease outcome, the causal pathway from the variants to the outcome can be difficult to disentangle. For example, the chemokine receptor gene cluster contains genetic variants associated with various cytokines.
arxiv
High expression of antioxidant proteins in dendritic cells: possible implications in atherosclerosis [PDF]
Mol Cell Proteomics 5 (04/2006) 726-36, 2006 Dendritic cells (DCs) display the unique ability to activate naive T cells and to initiate primary T cell responses revealed in DC-T cell alloreactions. DCs frequently operate under stress conditions. Oxidative stress enhances the production of inflammatory cytokines by DCs.
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Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
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Genetic Regulation of Cytokine Response in Patients with Acute Community-acquired Pneumonia [PDF]
arXiv, 2021 Background: Community-acquired pneumonia (CAP) is an acute disease condition with a high risk of rapid deteriorations. We analysed the influence of genetics on cytokine regulation to obtain a better understanding of patient's heterogeneity. Methods: For up to N=389 genotyped participants of the PROGRESS study of hospitalised CAP patients, we performed ...
arxiv
A Fast Second-Order Explicit Predictor-Corrector Numerical Technique To Investigating And Predicting The Dynamic Of Cytokine Levels And Human Immune Cells Activation In Response To Gram-Positive Bacteria: Staphylococcus Aureus [PDF]
arXiv, 2023 This paper develops a second-order explicit predictor-corrector numerical approach for solving a mathematical model on the dynamic of cytokine expressions and human immune cell activation in response to the bacterium staphylococcus aureus (S. aureus). The proposed algorithm is at least zero-stable and second-order accurate.
arxiv