Results 11 to 20 of about 5,303 (75)
Сибирский онкологический журнал, 2023 T cells expressing checkpoint receptors PD-1, TIM-3 etc., are potential targets for monoclonal antibody immunotherapy in multiple myeloma (MM). However, checkpoint expressing T cell compartment includes different subsets, and their dysregulation ...
E. V. Batorov +7 more
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Distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein: a potential hint at the possibility of local iron dysregulation in COVID-19 [PDF]
Biol. Direct 15 (2020) 19, 2020 The spike glycoprotein of the SARS-CoV-2 virus, which causes COVID-19, has attracted attention for its vaccine potential and binding capacity to host cell surface receptors. Much of this research focus has centered on the ectodomain of the spike protein. The ectodomain is anchored to a transmembrane region, followed by a cytoplasmic tail.
arxiv +1 more source
Evolution of Class I cytokine receptors
BMC Evolutionary Biology, 2007 Background The Class I cytokine receptors have a wide range of actions, including a major role in the development and function of immune and blood cells. However, the evolution of the genes encoding them remains poorly understood. To address this we have
Ward Alister C, Liongue Clifford
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Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K
Frontiers in Endocrinology, 2017 Type I and II cytokine receptors are cell surface sensors that bind cytokines in the extracellular environment and initiate intracellular signaling to control processes such as hematopoiesis, immune function, and cellular growth and development.
Lily Jun-shen Huang +2 more
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Haematologica, 2010 Background Cytokine-induced killer cells are ex vivo-expanded cells with potent antitumor activity. The infusion of cytokine-induced killer cells in patients with acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplant is ...
Virna Marin +9 more
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Frontiers in Immunology, 2015 Control of cytokine production by immune cells is pivotal for counteracting infections via orchestration of local and systemic inflammation. Although their contribution has long been underexposed, it has recently become clear that human Fc gamma ...
Lisa T C Vogelpoel +3 more
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Metareview-informed Explainable Cytokine Storm Detection during CAR-T cell Therapy [PDF]
arXiv, 2022 Cytokine release syndrome (CRS), also known as cytokine storm, is one of the most consequential adverse effects of chimeric antigen receptor therapies that have shown promising results in cancer treatment. When emerging, CRS could be identified by the analysis of specific cytokine and chemokine profiles that tend to exhibit similarities across patients.
arxiv
Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]
arXiv, 2022 The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv
Differences in innate cytokine responses between European and African children. [PDF]
PLoS ONE, 2014 Although differences in immunological responses between populations have been found in terms of vaccine efficacy, immune responses to infections and prevalence of chronic inflammatory diseases, the mechanisms responsible for these differences are not ...
Lucja A Labuda +9 more
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Perspective: Daniela Novick, cytokines and their receptors
Frontiers in Immunology, 2023 This Perspective highlights the work of Dr. Daniela Novick in the field of cytokine biology. Using affinity chromatography to characterize cytokine-binding proteins, she identified soluble forms of the receptors as well as binding proteins for several ...
Pietro Ghezzi +2 more
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