Results 11 to 20 of about 646,725 (280)
Identification of cytokine-induced cell communications by pan-cancer meta-analysis [PDF]
PeerJ, 2023 Cancer immune responses are complex cellular processes in which cytokine–receptor interactions play central roles in cancer development and response to therapy; dysregulated cytokine–receptor communication may lead to pathological processes, including ...
Yining Liu, Min Zhao, Hong Qu
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Structure of the IL-27 quaternary receptor signaling complex
eLife, 2022 Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis.
Nathanael A Caveney +4 more
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Cells, 2023 Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process.
Krisztina Nikovics +6 more
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Inflammation and Regeneration, 2022 Recent advances in our understanding in the immune-mediated inflammatory diseases (IMID) are explored and promoted by the targeted treatment. Among these targets, cytokines and cytokine receptors have become the good candidates for the drug development ...
Tsutomu Takeuchi
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Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides [PDF]
, 2008 While mannosylation targets antigens to mannose receptors on dendritic cells (DC), the resultant immune response is suboptimal. We hypothesized that the addition of toll-like receptor (TLR) ligands would enhance the DC response to mannosylated antigens ...
Dan, Jennifer M. +3 more
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QTY Code-designed Water-soluble Fc-fusion Cytokine Receptors Bind to their Respective Ligands
QRB Discovery, 2020 Cytokine release syndrome (CRS), or ‘cytokine storm’, is the leading side effect during chimeric antigen receptor (CAR)-T therapy that is potentially life-threatening.
Shilei Hao +3 more
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Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
iScience, 2021 Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization ...
Sofie Mossner +2 more
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Soluble cytokine receptors [PDF]
Blood, 1996 HE WORD “HORMONE” comes from the Greek, meaning to set in motion, whereas “humoral” comes from the Latin for ‘‘liquid.’’ Classical hormones are delivered in the blood “to set in motion” target cell proliferation or functional activation. Therefore, humoral specificity depends on the hormone’s ability to interact only with cells expressing the ...
M L, Heaney, D W, Golde
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Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor. [PDF]
PLoS ONE, 2011 Length and intensity of signal transduction via cytokine receptors is precisely regulated. Degradation of certain cytokine receptors is mediated by the ubiquitin ligase SCF(βTrCP).
Joyce Putters +5 more
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Microbial Phagocytic Receptors and Their Potential Involvement in Cytokine Induction in Macrophages
Frontiers in Immunology, 2021 Phagocytosis is an essential process for the uptake of large (>0.5 µm) particulate matter including microbes and dying cells. Specialized cells in the body perform phagocytosis which is enabled by cell surface receptors that recognize and bind target ...
Yan Lin Fu +3 more
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