Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]
arXiv, 2022 The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv
P1 receptors and cytokine secretion [PDF]
Purinergic Signalling, 2007 Evidence has accumulated in the last three decades to suggest tissue protection and regeneration by adenosine in multiple different cell types. Adenosine produced in hypoxic or inflamed environments reduces tissue injury and promotes repair by receptor-mediated mechanisms.
M.P. Abbracchio, S. Ceruti
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Differences in innate cytokine responses between European and African children. [PDF]
PLoS ONE, 2014 Although differences in immunological responses between populations have been found in terms of vaccine efficacy, immune responses to infections and prevalence of chronic inflammatory diseases, the mechanisms responsible for these differences are not ...
Lucja A Labuda +9 more
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Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta [PDF]
Arthritis Research \& Therapy, 2010, 13 (1), pp.R23.
\Transforming growth factor beta (TGF$\beta$) plays a central role in morphogenesis, growth, and cell differentiation. This cytokine is particularly important in cartilage where it regulates cell proliferation and extracellular matrix synthesis. While the action of TGF$\beta$ on chondrocyte metabolism has been extensively catalogued, the modulation of ...
arxiv +1 more source
TRAF Regulation of IL-17 Cytokine Signaling
Frontiers in Immunology, 2019 Tumor necrosis factor receptor (TNFR)-associated factors or (TRAFs) are important mediators of Interleukin-17 (IL-17) cytokine signaling and contribute to driving tissue responses that are crucial for protective immunity but are often implicated in ...
Shadi Swaidani +5 more
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Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
iScience, 2021 Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization ...
Sofie Mossner +2 more
doaj
Cytokine-Leukotriene Receptor Interactions [PDF]
The Scientific World JOURNAL, 2007 Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors. A privileged interaction exists between these lipid mediators and another group of molecules essential for inflammation and immune ...
Marek Rola-Pleszczynski, Jana Stankova
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Protein Palmitoylation in Leukocyte Signaling and Function
Frontiers in Cell and Developmental Biology, 2020 Palmitoylation is a post-translational modification (PTM) based on thioester-linkage between palmitic acid and the cysteine residue of a protein. This covalent attachment of palmitate is reversibly and dynamically regulated by two opposing sets of ...
Xiaoyuan Yang +5 more
doaj +1 more source
Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization [PDF]
arXiv, 2021 When genetic variants in a gene cluster are associated with a disease outcome, the causal pathway from the variants to the outcome can be difficult to disentangle. For example, the chemokine receptor gene cluster contains genetic variants associated with various cytokines.
arxiv
Cytokine production and signaling pathways in respiratory virus infection
Frontiers in Microbiology, 2013 It has been confirmed that respiratory virus infections can induce abberant cytokine production in the host. These cytokines may be associated with both elimination of the virus and complications in the host, such as virus-induced asthma.
Hirokazu eKimura +4 more
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