Results 21 to 30 of about 638,477 (202)
PLoS ONE, 2020 Cytokine signaling is transmitted by cell surface receptors which act as natural biological switches to control cellular functions such as immune reactions.
Sofie Mossner +5 more
doaj +1 more source
Медицинская иммунология, 2023 TNFa is a pro-inflammatory cytokine that is signaled through type 1 (TNFR1) and type 2 (TNFR2) receptors. TNFR1 normally mediates apoptosis, cell survival, and cytokine secretion, while TNFR2 selectively mediates cell survival and cytokine secretion. But
Yu. A. Lopatnikova +6 more
doaj +1 more source
libtissue - implementing innate immunity [PDF]
, 2006 In a previous paper the authors argued the case for incorporating ideas from innate immunity into articficial immune systems (AISs) and presented an outline for a conceptual framework for such systems.
Aickelin, Uwe, Twycross, Jamie
core +3 more sources
Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice [PDF]
, 2016 Introduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
De Beuckelaer, Ans +10 more
core +1 more source
Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]
, 2007 Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD +6 more
core +1 more source
Evolution of γ chain cytokines: Mechanisms, methods and applications
Computational and Structural Biotechnology Journal, 2022 The common γ chain family of cytokines and their receptors play fundamental roles in the immune system. Evolutionary studies of γ chain cytokines have elegantly illustrated how the immune system adapts to ever-changing environmental conditions.
Magdalena Antczak +4 more
doaj +1 more source
Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells : implications for adoptive immunotherapy after allogeneic stem cell transplantation [PDF]
, 2010 Background: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines ...
Kuçi, Selim +12 more
core +1 more source
Evolution of Class I cytokine receptors
BMC Evolutionary Biology, 2007 Background The Class I cytokine receptors have a wide range of actions, including a major role in the development and function of immune and blood cells. However, the evolution of the genes encoding them remains poorly understood. To address this we have
Ward Alister C, Liongue Clifford
doaj +1 more source
Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K
Frontiers in Endocrinology, 2017 Type I and II cytokine receptors are cell surface sensors that bind cytokines in the extracellular environment and initiate intracellular signaling to control processes such as hematopoiesis, immune function, and cellular growth and development.
Lily Jun-shen Huang +2 more
doaj +1 more source
Сибирский онкологический журнал, 2023 T cells expressing checkpoint receptors PD-1, TIM-3 etc., are potential targets for monoclonal antibody immunotherapy in multiple myeloma (MM). However, checkpoint expressing T cell compartment includes different subsets, and their dysregulation ...
E. V. Batorov +7 more
doaj +1 more source