Results 21 to 30 of about 584,015 (163)

Multimerization strategies for efficient production and purification of highly active synthetic cytokine receptor ligands.

PLoS ONE, 2020
Cytokine signaling is transmitted by cell surface receptors which act as natural biological switches to control cellular functions such as immune reactions.
Sofie Mossner, Hoang T Phan, Saskia Triller, Jens M Moll, Udo Conrad, Jürgen Scheller   +5 more
doaj   +1 more source

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice [PDF]

, 2016
Introduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
De Beuckelaer, Ans, Grooten, Johan, Gustafsson, Jan-Ake, Lambrecht, Bart, Naessens, Thomas, Smet, Muriel, Steffensen, Knut R, Van Hoecke, Lien, Vander Beken, Seppe, Vergote, Karl, Willart, Monique   +10 more
core   +1 more source

libtissue - implementing innate immunity [PDF]

, 2006
In a previous paper the authors argued the case for incorporating ideas from innate immunity into articficial immune systems (AISs) and presented an outline for a conceptual framework for such systems.
Aickelin, Uwe, Twycross, Jamie
core   +3 more sources

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors [PDF]

, 2006
Peer reviewedPublisher ...
Bates, Steven, Bertram, Gwyneth, Brown, Alistair James Petersen, Buurman, Ed T, Collins, Claire, Ferwerda, Gerben, Gijzen, Karlijn, Gow, Neil Andrew Robert, Hobson, Richard Patrick, Hughes, Huw Bleddyn, Jacobs, Liesbeth, Jansen, Trees, Kullberg, Bart Jan, MacCallum, Donna Margaret, McKinnon, Alistair, Munro, Carol Anne, Netea, Mihai G, Odds, Frank Christopher, Torensma, Ruurd, Van der Meer, Jos W.M., Williams, David L.   +20 more
core   +2 more sources

Common Ɣ-chain cytokine receptors as functional phenotype markers of PD-1and TIM-3-positive T cells in multiple myeloma

Сибирский онкологический журнал, 2023
T cells expressing checkpoint receptors PD-1, TIM-3 etc., are potential targets for monoclonal antibody immunotherapy in multiple myeloma (MM). However, checkpoint expressing T cell compartment includes different subsets, and their dysregulation ...
E. V. Batorov, V. A. Aristova, G. Yu. Ushakova, S. A. Sizikova, V. V. Denisova, E. Ya. Shevela, A. A. Ostanin, E. R. Chernykh   +7 more
doaj   +1 more source

Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K

Frontiers in Endocrinology, 2017
Type I and II cytokine receptors are cell surface sensors that bind cytokines in the extracellular environment and initiate intracellular signaling to control processes such as hematopoiesis, immune function, and cellular growth and development.
Lily Jun-shen Huang, Ping-hung Chen, Huiyu Yao   +2 more
doaj   +1 more source

Evolution of Class I cytokine receptors

BMC Evolutionary Biology, 2007
Background The Class I cytokine receptors have a wide range of actions, including a major role in the development and function of immune and blood cells. However, the evolution of the genes encoding them remains poorly understood. To address this we have
Ward Alister C, Liongue Clifford
doaj   +1 more source

Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors

Haematologica, 2010
Background Cytokine-induced killer cells are ex vivo-expanded cells with potent antitumor activity. The infusion of cytokine-induced killer cells in patients with acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplant is ...
Virna Marin, Irene Pizzitola, Valentina Agostoni, Greta Maria Paola Giordano Attianese, Helene Finney, Alastair Lawson, Martin Pule, Raphael Rousseau, Andrea Biondi, Ettore Biagi   +9 more
doaj   +1 more source

Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]

, 2016
Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
McCoy, Kathleen L.
core   +4 more sources

Perspective: Daniela Novick, cytokines and their receptors

Frontiers in Immunology, 2023
This Perspective highlights the work of Dr. Daniela Novick in the field of cytokine biology. Using affinity chromatography to characterize cytokine-binding proteins, she identified soluble forms of the receptors as well as binding proteins for several ...
Pietro Ghezzi, Giamila Fantuzzi, Charles A. Dinarello   +2 more
doaj   +1 more source