Results 1 to 10 of about 142,564 (264)

Fibroblast growth factor receptors in breast cancer [PDF]

Tumor Biology, 2017
Fibroblast growth factor receptors are growth factor receptor tyrosine kinases, exerting their roles in embryogenesis, tissue homeostasis, and development of breast cancer.
Shuwei Wang, Zhongyang Ding
doaj   +3 more sources

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +3 more sources

Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae [PDF]

PeerJ, 2022
Background and Objective A key pathway controlling skeletal development is fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling. Major regulatory functions of FGF signaling are chondrogenesis, endochondral and intramembranous bone development.
Liesbeth Gebuijs, Frank A. Wagener, Jan Zethof, Carine E. Carels, Johannes W. Von den Hoff, Juriaan R. Metz   +5 more
doaj   +2 more sources

Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling

Cells, 2021
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson, Michael P. Smith, Chiara Francavilla   +2 more
doaj   +1 more source

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis [PDF]

Cytokine & Growth Factor Reviews, 2005
Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins.
PRESTA, Marco, DELL'ERA, Patrizia, MITOLA, Stefania Maria Filomena, MORONI, Emanuela, RONCA, Roberto, RUSNATI, Marco   +5 more
openaire   +2 more sources

VEGFR1-tyrosine kinase signaling in pulmonary fibrosis

Inflammation and Regeneration, 2021
Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3.
Hideki Amano, Yoshio Matsui, Ko Hatanaka, Kanako Hosono, Yoshiya Ito   +4 more
doaj   +1 more source

Efficacy and safety of nintedanib in patients with non-small cell lung cancer, and novel insights in radiation-induced lung toxicity

Frontiers in Oncology, 2023
Nintedanib is a tyrosine kinase inhibitor of fibroblast growth factor-, vascular endothelial growth factor-, and platelet-derived growth factor receptors.
Shu Yan, Shuyu Xue, Tiantian Wang, Ruihang Gao, Hanqiao Zeng, Qianmeng Wang, Xiaojing Jia   +6 more
doaj   +1 more source

Fibroblastic growth factor as a diagnostic and prognostic marker in odontogenic cysts and tumors: A systematic review

Journal of Pharmacy and Bioallied Sciences, 2021
Cellular signaling proteins maintain the basic activities of cell and communication, between the cells for normal growth and development and pathological situation as well.
Gururaj Narayana Rao, Adlin Saroja Rosaian, Gowthami Jawahar, P Hari Nivas Raj, J Beryl Rachel, P Blessing Emmanuel   +5 more
doaj   +1 more source

Recent developments in receptor tyrosine kinases targeted anticancer therapy [PDF]

Veterinary World, 2016
Novel concepts and understanding of receptors lead to discoveries and optimization of many small molecules and antibodies as anti-cancerous drugs. Receptor tyrosine kinases (RTKs) are such a promising class of receptors under the investigation in past ...
Samir H. Raval , Ratn D. Singh , Dilip V. Joshi , Hitesh B. Patel , Shailesh K. Mody   +4 more
doaj   +1 more source

Fibroblast Growth Factor Receptor Functions in Glioblastoma [PDF]

Cells, 2019
Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations in glioblastoma.
Ana Jimenez-Pascual, Florian A. Siebzehnrubl   +1 more
openaire   +4 more sources