Fibroblast growth factor receptors in breast cancer [PDF]
Fibroblast growth factor receptors are growth factor receptor tyrosine kinases, exerting their roles in embryogenesis, tissue homeostasis, and development of breast cancer.
Shuwei Wang, Zhongyang Ding
doaj +5 more sources
Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors
Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both developmental and adult cells.
Shuyan Dai+4 more
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Fibroblast Growth Factor Receptor Functions in Glioblastoma [PDF]
Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations
Ana Jimenez-Pascual+1 more
semanticscholar +6 more sources
Receptor Specificity of the Fibroblast Growth Factor Family* [PDF]
Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns.
D. Ornitz+7 more
semanticscholar +4 more sources
Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer
Breast cancer (BC) is the most common malignancy and second only to lung cancer in terms of mortality in women. Despite the incredible progress made in this field, metastatic breast cancer has a poor prognosis.
Navid Sobhani+8 more
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Roles of Fibroblast Growth Factor Receptors in Carcinogenesis [PDF]
Abstract The fibroblast growth factor receptors (FGFR) play essential roles both during development and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that tightly regulate key biological processes, such as cell proliferation, survival, migration, and differentiation.
E. M. Haugsten+3 more
semanticscholar +4 more sources
Signal transduction by fibroblast growth factor receptors. [PDF]
The fibroblast growth factor family, with its prototype members acidic FGF (FGF-1) and basic FGF (FGF-2), binds to four related receptor tyrosine kinases, expressed on most types of cells in tissue culture.
P. Klint, L. Claesson-Welsh
semanticscholar +4 more sources
Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae [PDF]
Background and Objective A key pathway controlling skeletal development is fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling. Major regulatory functions of FGF signaling are chondrogenesis, endochondral and intramembranous bone development.
Liesbeth Gebuijs+5 more
doaj +2 more sources
Functions of fibroblast growth factors and their receptors [PDF]
Fibroblast growth factors were first characterized twenty years ago as mitogens of cultured fibroblasts. Despite a wealth of data from experiments in vitro, insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their ...
Wilkie, A+3 more
openaire +3 more sources
Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson+2 more
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