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Fibroblast growth factor receptors in breast cancer [PDF]
Tumor Biology, 2017 Fibroblast growth factor receptors are growth factor receptor tyrosine kinases, exerting their roles in embryogenesis, tissue homeostasis, and development of breast cancer.
Shuwei Wang, Zhongyang Ding
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Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling
Cells, 2021 Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson +2 more
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Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors
Cells, 2019 Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases expressed on the cell membrane that play crucial roles in both developmental and adult cells.
Shuyan Dai +4 more
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Fibroblast Growth Factor Receptor Functions in Glioblastoma [PDF]
Cells, 2019 Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations
Ana Jimenez-Pascual +1 more
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Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. [PDF]
Cytokine & Growth Factor Reviews, 2005 Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins.
M. Presta +5 more
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Signal transduction by fibroblast growth factor receptors. [PDF]
Frontiers in Bioscience, 1999 The fibroblast growth factor family, with its prototype members acidic FGF (FGF-1) and basic FGF (FGF-2), binds to four related receptor tyrosine kinases, expressed on most types of cells in tissue culture. In many respects, the FGF receptors appear similar to other growth factor receptors. Thus, dimerization of receptor monomers upon ligand binding is
P. Klint, L. Claesson-Welsh
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F1000ResearchFibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler +2 more
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Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae [PDF]
PeerJ, 2022 Background and Objective A key pathway controlling skeletal development is fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling. Major regulatory functions of FGF signaling are chondrogenesis, endochondral and intramembranous bone development.
Liesbeth Gebuijs +5 more
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VEGFR1-tyrosine kinase signaling in pulmonary fibrosis
Inflammation and Regeneration, 2021 Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3.
Hideki Amano +4 more
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The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
Cells, 2021 Fibroblast growth factors (FGFs) are a large family of secretory molecules that act through tyrosine kinase receptors known as FGF receptors. They play crucial roles in a wide variety of cellular functions, including cell proliferation, survival ...
M. Farooq +3 more
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