Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway [PDF]
, 2006 We report a multiwavelength (X-ray, ultraviolet/optical/infrared, radio) analysis of the relativistic tidal disruption event candidate Sw J2058+05 from 3 months to 3 yr post-discovery in order to study its properties and compare its behavior with that of
Bower, Geoffrey C. +15 more
core +2 more sources
Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins
Cells, 2019 Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute signaling circuits that transmit signals across the plasma membrane, regulating pivotal cellular processes like differentiation, migration, proliferation, and apoptosis.
Marta Latko +6 more
doaj +1 more source
Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors. [PDF]
PLoS ONE, 2013 Malignant rhabdoid tumors (MRTs) are aggressive pediatric cancers arising in brain, kidney and soft tissues, which are characterized by loss of the tumor suppressor SNF5/SMARCB1.
Simon Wöhrle +17 more
doaj +1 more source
Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding. [PDF]
, 2013 The tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine playing a key role in tissue regeneration and remodeling.
Baehner, Monika +7 more
core +6 more sources
The Fibroblast Growth Factor signaling pathway
Wiley Interdisciplinary Reviews: Developmental Biology, 2015 The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs).
D. Ornitz, N. Itoh
semanticscholar +1 more source
A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice [PDF]
, 2013 The binding of vascular endothelial growth factor (VEGF) to VEGF receptor-2 (VEGFR-2) on the surface of vascular endothelial cells stimulates many steps in the angiogenic pathway.
A Janssen +52 more
core +1 more source
Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation. [PDF]
, 2020 Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor ...
Bisom-Rapp, Ezra W +4 more
core +2 more sources
Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer
Gastroenterology Research and Practice, 2015 Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer (GC), although outcomes remain unfavorable.
Mikito Inokuchi +5 more
doaj +1 more source
Di-san junyi daxue xuebao, 2019 Objective To observe the developmental process of murine meniscus after birth and investigate the expression patterns of 3 types of fibroblast growth factor receptors (FGFRs) during this process. Methods Mice at different ages (1 d old and 1, 2, 4, 6 and
LI Fangfang +4 more
doaj +1 more source
iScience, 2019 Summary: Lung epithelial cells and fibroblasts are key cell populations in lung development. Fibroblasts support type 2 alveolar epithelial cells (AEC2) in the developing and mature lung.
Kazushige Shiraishi +6 more
doaj +1 more source