Results 41 to 50 of about 3,330,792 (348)

Immunoglobulin G1 binding with various molecular receptors: A new paradigm of IgG1 as a potential adjuvant

Journal of Acute Disease, 2019
Objective: To explore the possible IgG1 binding receptors by protein-protein docking experiments. Methods: The protein-protein cognate interactions such as IgG with Fc Receptors (FcRs) potentiate signaling cascades to ameliorate antigen uptake ...
Shweta Saxena, Vignesh Sounderrajan, Saravanan Konda Mani, Shakila Harshavardhan   +3 more
doaj   +1 more source

Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia

Journal of Neuroinflammation, 2022
Background There is growing evidence that neuroinflammation may contribute to schizophrenia neuropathology. Elevated pro-inflammatory cytokines are evident in the midbrain from schizophrenia subjects, findings that are driven by a subgroup of patients ...
A. Petty, L. J. Glass, D. A. Rothmond, T. Purves-Tyson, A. Sweeney, Y. Kondo, S. Kubo, M. Matsumoto, C. Shannon Weickert   +8 more
doaj   +1 more source

The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs [PDF]

The Journal of Immunology, 2003
Abstract Abs of the IgG isotype are efficiently transported from mother to neonate and have an extended serum t1/2 compared with Abs of other isotypes. Circumstantial evidence suggests that the MHC class I-related protein, the neonatal FcR (FcRn), is the FcR responsible for both in vivo functions.
Roopenian, D C, Christianson, G J, Sproule, T J, Brown, A C, Akilesh, S, Jung, N, Petkova, S, Avanessian, L, Choi, E Y, Shaffer, D J, Eden, P A, Anderson, C L   +11 more
openaire   +2 more sources

Glyco-biomarkers: Potential determinants of cellular physiology and pathology [PDF]

, 2008
Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly,
Alavi, A, Axford, JS
core   +2 more sources

Pentraxins and Fc Receptor-Mediated Immune Responses

Frontiers in Immunology, 2018
C-reactive protein (CRP) is a member of the pentraxin family of proteins. These proteins are highly conserved over the course of evolution being present as far back as 250 million years ago.
Jinghua Lu, Carolyn Mold, Carolyn Mold, Terry W. Du Clos, Peter D. Sun   +4 more
doaj   +1 more source

Autoantibodies against muscarinic receptors in breast cancer: their role in tumor angiogenesis. [PDF]

PLoS ONE, 2013
The presence of autoantibodies in cancer has become relevant in recent years. We demonstrated that autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells.
María Gabriela Lombardi, María Pía Negroni, Laura Tatiana Pelegrina, María Ester Castro, Gabriel L Fiszman, María Eugenia Azar, Carlos Cresta Morgado, María Elena Sales   +7 more
doaj   +1 more source

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

Nature Communications, 2018
Acute allergic symptoms are caused by allergen-induced crosslinking of allergen-specific immunoglobulin E (IgE) bound to Fc-epsilon receptors on effector cells.
Jamie M. Orengo, Allen Radin, V. Kamat, A. Badithe, Li-Hong Ben, Brandy L Bennett, S. Zhong, D. Birchard, A. Limnander, A. Rafique, Joannie Bautista, A. Kostić, D. Newell, Xunbao Duan, M. Franklin, William C. Olson, Tammy T. Huang, N. Gandhi, A. LipsichLeah, N. Stahl, N. Papadopoulos, Andrew J. Murphy, G. Yancopoulos   +22 more
semanticscholar   +1 more source

Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia

Frontiers in Immunology, 2023
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate.
Zoltán Szittner, Zoltán Szittner, Arthur E. H. Bentlage, Arthur E. H. Bentlage, A. Robin Temming, A. Robin Temming, David E. Schmidt, David E. Schmidt, Remco Visser, Remco Visser, Suzanne Lissenberg-Thunnissen, Suzanne Lissenberg-Thunnissen, Juk Yee Mok, Wim J. E. van Esch, Myrthe E. Sonneveld, Myrthe E. Sonneveld, Erik L. de Graaf, Erik L. de Graaf, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, Masja de Haas, Masja de Haas, C. Ellen van der Schoot, C. Ellen van der Schoot, Gestur Vidarsson, Gestur Vidarsson   +26 more
doaj   +1 more source

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

Frontiers in Immunology, 2019
Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life expectancy. Except for immune checkpoint inhibition, the mode of action of many antibodies is to recognize overexpressed or specific tumor antigens and initiate
A. Brandsma, S. Bondza, Mitchell Evers, Rosanne Koutstaal, Maaike Nederend, J. Jansen, T. Rösner, T. Valerius, J. Leusen, T. ten Broeke   +9 more
semanticscholar   +1 more source

Regulation of elastase and plasminogen activator secretion in resident and inflammatory macrophages by receptors for the Fc domain of immunoglobulin G. [PDF]

, 1984
We have determined that the interaction of IgG-coated erythrocytes (EIgG) and complement-coated erythrocytes (EIgMC) with macrophage Fc and complement receptors, respectively, modulates the secretion of the neutral proteinases, elastase, and plasminogen ...
Takemura, R, Werb, Z
core