Results 21 to 30 of about 46,677 (173)

PATHOGENETIC MECHANISMS OF LEPTIN RESISTANCE

Российский кардиологический журнал, 2015
Leptin is a regulatory protein from adipokines family, that maintain energy homeostasis of the body and deter obesity development. Impaired transfer of leptin signals to hypothalamus leads to leptin resistance and its adverse complications. Understanding
G. A. Chumakova, A. V. Ott, N. G. Veselovskaya, O. V. Gritsenko, N. N. Shenkova   +4 more
doaj   +1 more source

Relationship Between Circulating Metabolic Hormones and Their Central Receptors During Ovariectomy-Induced Weight Gain in Rats

Frontiers in Physiology, 2022
Although increasing research focuses on the phenomenon of body weight gain in women after menopause, the complexity of body weight regulation and the array of models used to investigate it has proven to be challenging.
Kaitlin E. Burch, Kelly McCracken, Daniel J. Buck, Randall L. Davis, Dusti K. Sloan, Kathleen S. Curtis   +5 more
doaj   +1 more source

Gender dimorphism in skeletal muscle leptin receptors, serum leptin and insulin sensitivity. [PDF]

PLoS ONE, 2008
To determine if there is a gender dimorphism in the expression of leptin receptors (OB-R170, OB-R128 and OB-R98) and the protein suppressor of cytokine signaling 3 (SOCS3) in human skeletal muscle, the protein expression of OB-R, perilipin A, SOCS3 and ...
Borja Guerra, Teresa Fuentes, Safira Delgado-Guerra, Amelia Guadalupe-Grau, Hugo Olmedillas, Alfredo Santana, Jesus Gustavo Ponce-Gonzalez, Cecilia Dorado, José A L Calbet   +8 more
doaj   +1 more source

The role of leptin resistance in the development of thyroid neoplasia

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. Leptin influences energy metabolism, as it is able to inform the central nervous system about adipose tissue reserves, and is also an important neuroendocrine regulator.
O.S. Miroshnichenko
doaj   +1 more source

Leptin regulates gonadotropins and steroid receptors in the rats ovary

Nutrición Hospitalaria, 2013
The leptin hormone is important to satiety and an important link between the nutritional status and reproductive processes. Owing to the contradictory effects of leptin on the ovary and the failure to clarify the precise mechanism by which leptin affects
Fernanda Silveira Cavalcante, Verónica Aiceles, Cristiane da Fonte Ramos   +2 more
doaj   +1 more source

Absence of functional leptin receptor isoforms in the POUND (Lepr(db/lb)) mouse is associated with muscle atrophy and altered myoblast proliferation and differentiation. [PDF]

PLoS ONE, 2013
Leptin receptors are abundant in human skeletal muscle, but the role of leptin in muscle growth, development and aging is not well understood. Here we utilized a novel mouse model lacking all functional leptin receptor isoforms (POUND mouse, Lepr(db/lb))
Phonepasong Arounleut, Matthew Bowser, Sunil Upadhyay, Xing-Ming Shi, Sadanand Fulzele, Maribeth H Johnson, Alexis M Stranahan, William D Hill, Carlos M Isales, Mark W Hamrick   +9 more
doaj   +1 more source

Revising Berg-Purcell for finite receptor kinetics [PDF]

, 2021
From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv   +1 more source

Microbiome affects mice metabolic homeostasis via differential regulation of gene expression in the brain and gut. [PDF]

Physiol Rep
The gut microbiome (GMB) regulates digestion, metabolism, immunity, and energy homeostasis. This study investigates how gut microbiota integrate the regulation in the neuroendocrine and enteroendocrine systems, with a focus on G protein‐coupled receptors
Milhouse W, Organski AC, Sun X, Ai D, Zhou B, Cross TL, Ren H.   +6 more
europepmc   +2 more sources

Leptin Elicits LTC4 Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD2 Receptors

Frontiers in Immunology, 2018
Leptin is a cytokine, produced mainly by mature adipocytes, that regulates the central nervous system, mainly to suppress appetite and stimulate energy expenditure.
Natália R. T. Amorim, Tatiana Luna-Gomes, Tatiana Luna-Gomes, Marcos Gama-Almeida, Glaucia Souza-Almeida, Claudio Canetti, Bruno L. Diaz, Peter F. Weller, Patricia Torres Bozza, Clarissa M. Maya-Monteiro, Christianne Bandeira-Melo   +10 more
doaj   +1 more source

Leptin Suppresses Glutamate-Induced Apoptosis Through Regulation of ERK1/2 Signaling Pathways in Rat Primary Astrocytes

Cellular Physiology and Biochemistry, 2017
Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes.
Hyunju Park, So-Hee Ahn, Yieun Jung, Joo Chun Yoon, Youn-Hee Choi   +4 more
doaj   +1 more source