Results 21 to 30 of about 2,401,298 (264)

Leptin Suppresses Glutamate-Induced Apoptosis Through Regulation of ERK1/2 Signaling Pathways in Rat Primary Astrocytes

Cellular Physiology and Biochemistry, 2017
Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes.
Hyunju Park, So-Hee Ahn, Yieun Jung, Joo Chun Yoon, Youn-Hee Choi   +4 more
doaj   +1 more source

The Effects of Leptin on Glial Cells in Neurological Diseases

Frontiers in Neuroscience, 2019
It is known that various endocrine modulators, including leptin and ghrelin, have neuroprotective roles in neurological diseases. Leptin is a hormone produced by adipocytes and was originally identified as a gene related to obesity in mice.
Yuki Fujita, Yuki Fujita, Toshihide Yamashita, Toshihide Yamashita, Toshihide Yamashita, Toshihide Yamashita   +5 more
doaj   +1 more source

Genetic identification of leptin neural circuits in energy and glucose homeostases

Nature, 2018
Leptin, a hormone produced in white adipose tissue, acts in the brain to communicate fuel status, suppress appetite following a meal, promote energy expenditure and maintain blood glucose stability1,2.
Jie Xu, Christopher Bartolome, C. Low, Xinchi Yi, Cheng-hao Chien, Peng Wang, D. Kong   +6 more
semanticscholar   +1 more source

Adipokine Leptin Co-operates With Mechanosensitive Ca2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells

Frontiers in Cell and Developmental Biology, 2021
In postmenopausal women, a major risk factor for the development of breast cancer is obesity. In particular, the adipose tissue-derived adipokine leptin has been strongly linked to tumor cell proliferation, migration, and metastasis, but the underlying ...
Anna Acheva, Tytti Kärki, Niccole Schaible, Ramaswamy Krishnan, Sari Tojkander   +4 more
doaj   +1 more source

CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin

Molecular Metabolism, 2014
Metabolic flexibility allows rapid adaptation to dietary change, however, little is known about the CNS mechanisms regulating this process. Neurons in the hypothalamic ventromedial nucleus (VMN) participate in energy balance and are the target of the ...
Pierre Cardinal, Caroline André, Carmelo Quarta, Luigi Bellocchio, Samantha Clark, Melissa Elie, Thierry Leste-Lasserre, Marlene Maitre, Delphine Gonzales, Astrid Cannich, Uberto Pagotto, Giovanni Marsicano, Daniela Cota   +12 more
doaj   +1 more source

Assessment of leptin and resistin levels in non-obese multiple myeloma patients and their relation with Ig level and disease stage

Journal of the Egyptian National Cancer Institute, 2014
Introduction: Multiple myeloma (MM) accounts for approximately 0.8% of all cancer diagnoses and 0.9% of cancer deaths. Leptin receptors were expressed on CD34+ cells.
Noha E. Esheba, Abeer Shahba, Ola El Shora   +2 more
doaj   +1 more source

Leptin and leptin receptor evaluation in atherosclerotic plaques in patients with type 2 diabetes mellitus

Терапевтический архив, 2021
Background. Diabetes mellitus (DM) is a significant predictor of atherosclerosis, cardiovascular disease, and cardiovascular mortality. It is known that atherosclerosis occurs earlier in patients with diabetes, reducing the duration of their life. Leptin
Diana A. Dimitrova, Ilya A. Mikhailov, Konstantin Yu. Tokarev, Marina S. Michurova, Anna M. Gorbacheva, Natalia V. Danilova, Pavel G. Malkov, Viktor Yu. Kalashnikov   +7 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

CORRELATION OF LEPTIN AND ADIPONECTIN RECEPTOR EXPRESSION WITH CLINICOPATHOLOGICAL PARAMETERS IN COLORECTAL CARCINOMA - A CROSS-SECTIONAL PROSPECTIVE STUDY [PDF]

Arquivos de Gastroenterologia
Background: Colorectal carcinoma (CRC) is one of the common carcinomas with a rising incidence of metastasis due to its advanced stage of presentation.
Priyanka PARMESH, Udupi Shastri DINESH, Ajay S KHANDAGALE, Anil Bargale BAPU, Roshni SADASHIV, Pradnya REDDY   +5 more
doaj   +1 more source

Leptin and Notch Signaling Cooperate in Sustaining Glioblastoma Multiforme Progression

Biomolecules, 2020
Glioblastoma multiforme (GBM) is the most malignant form of glioma, which represents one of the commonly occurring tumors of the central nervous system.
Salvatore Panza, Umberto Russo, Francesca Giordano, Antonella Leggio, Ines Barone, Daniela Bonofiglio, Luca Gelsomino, Rocco Malivindi, Francesca Luisa Conforti, Giuseppina Daniela Naimo, Cinzia Giordano, Stefania Catalano, Sebastiano Andò   +12 more
doaj   +1 more source