Results 41 to 50 of about 2,401,298 (264)
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, and fibroblast growth factor [FGF]‐21) were measured using banked enrollment serum from participants in a longitudinal RA cohort.
Joshua F. Baker +9 more
wiley +1 more source
Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period. [PDF]
PLoS ONE, 2015 Reproduction requires adequate energy stores for parents and offspring to survive. Kiss1 neurons, which are essential for fertility, have the potential to serve as the central sensors of metabolic factors that signal to the reproductive axis the presence
Xiaoliang Qiu +10 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim +16 more
wiley +1 more source
Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes
Frontiers in PhysiologyIntroductionThe leading cause of death in type 2 diabetes mellitus (T2DM) patients is cardiovascular-related events, including myocardial infraction-induced ventricular arrhythmia.
Anthony J. Evans +7 more
doaj +1 more source
Leptin potentiates astrogenesis in the developing hypothalamus
Molecular Metabolism, 2015 Background: The proper establishment of hypothalamic feeding circuits during early development has a profound influence on energy homeostasis, and perturbing this process could predispose individuals to obesity and its associated consequences later in ...
Daniele M. Rottkamp +9 more
doaj +1 more source
Enhanced Hypothalamic Leptin Signaling in Mice Lacking Dopamine D2 Receptors*
Journal of Biological Chemistry, 2010 The dopamine D2 receptor (D2R) plays a critical role in diverse neurophysiological functions. D2R knock-out mice (D2R−/−) show reduced food intake and body weight while displaying an increased basal energy expenditure level, compared with their wild type
Kyu seok Kim +10 more
semanticscholar +1 more source
Advances in Bioprinting to Model Immune‐Mediated Skin Diseases
Advanced Healthcare Materials, EarlyView.This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández +4 more
wiley +1 more source
The role of leptin in selected skin diseases
Lipids in Health and Disease, 2020 Leptin is an adipokine, adipocyte-derived compound, which acts both as a hormone and cytokine. It is mainly synthesized by adipocytes of white adipose tissue. Leptin possesses pleiotropic functions including, among others, stimulation of angiogenesis and
Klaudia Dopytalska +4 more
doaj +1 more source
Leptin in the Respiratory Tract: Is There a Role in SARS-CoV-2 Infection?
Frontiers in Physiology, 2021 Leptin is a pleiotropic adipocytokine involved in several physiologic functions, with a known role in innate and adaptive immunity as well as in tissue homeostasis.
Andreina Bruno +4 more
doaj +1 more source