Results 131 to 140 of about 9,646 (180)

Leukotriene-B4 Receptor and Signal Transduction

2000
When cells are stimulated with various agonists, cells release arachidonic acid by the action of phospholipases, and arachidonic acid is further converted to various types of leukotrienes (LTs; Samuelsson et al. 1987; Shimizu and Wolfe 1990; Serhan et al. 1996).
T, Shimizu, T, Yokomizo, T, Izumi
openaire   +2 more sources

Effect of a leukotriene B4 receptor antagonist on leukotriene B4-induced neutrophil chemotaxis in cavine dermis

Inflammation, 1989
Leukotriene B4 (LTB4) is a proinflammatory product of arachidonic acid metabolism that has been implicated as a mediator in a number of inflammatory diseases. When injected intradermally into the cavine. LTB4 elicits a dose-dependent immigration (chemotaxis) of neutrophils (PMNs) into the injection sites as assessed by the presence of a neutrophil ...
D J, Fretland, D L, Widomski, J M, Zemaitis, S W, Djurić, R L, Shone   +4 more
openaire   +2 more sources

LEUKOTRIENE B4/LEUKOTRIENE B4 RECEPTOR PATHWAY IS INVOLVED IN HEPATIC MICROCIRCULATORY DYSFUNCTION ELICITED BY ENDOTOXIN

Shock, 2008
Leukotrienes (LTs), metabolites of arachidonic acid through 5-lipoxygenase (5-LOX), have been known to play a role in leukocyte recruitment. However, the contribution of LTB4 to liver microcirculatory dysfunction during endotoxemia remains unknown. LTB4 receptor (BLT1) has been identified as a high-affinity receptor specific for LTB4. The present study
Sohei, Ito, Yoshiya, Ito, Hiroyuki, Katagiri, Tatsunori, Suzuki, Sumio, Hoka, Takehiko, Yokomizo, Takao, Shimizu, Masataka, Majima   +7 more
openaire   +2 more sources

Molecular Cloning and Characterization of Leukotriene B4 Receptor

1999
Leukotriene B4 (LTB4) is a potent proinflammatory and chemotactic factor biosynthesized in various tissues, which is involved in inflammation, immune responses and host defense against infection.1 LTB4 activates inflammatory cells by binding to its cell-surface receptor (BLT).
T, Izumi, T, Yokomizo, T, Igarashi, T, Shimizu   +3 more
openaire   +2 more sources

-alkoxyphenol leukotriene B4 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 1992
Abstract A series of ortho -alkoxyphenols containing a tetrazole acid sidechain have been prepared as antagonists of leukotriene B4 receptors. These compounds were tested as receptor antagonists of human neutrophil and guinea pig lung membrane leukotriene B4 receptors.
Michael J. Sofia, William T. Jackson, Davis L. Saussy, Steven A. Silbaugh, Larry L. Froelich, Sandra L. Cockerham, Peter W. Stengel   +6 more
openaire   +1 more source

Leukotriene B4 receptors as therapeutic targets for ophthalmic diseases

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2020
Leukotriene B4 (LTB4) is an inflammatory lipid mediator produced from arachidonic acid by multiple reactions catalyzed by two enzymes 5-lipoxygenase (5-LOX) and LTA4 hydrolase (LTA4H). The two receptors for LTB4 have been identified: a high-affinity receptor, BLT1, and a low-affinity receptor, BLT2.
Toshiaki, Hirakata, Akira, Matsuda, Takehiko, Yokomizo   +2 more
openaire   +2 more sources

Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist

European Journal of Pharmacology, 1992
The actions of LY255283, a leukotriene (LT) B4 receptor antagonist, were examined on guinea pig lung. LTB4 and LY255283 displaced [3H]LTB4 from its binding site on lung membranes with pKi values of 9.9 and 7.0, respectively. In the functional correlate of the binding studies, LY255283 competitively reduced contractile responses of lung parenchyma to ...
S A, Silbaugh, P W, Stengel, S L, Cockerham, C R, Roman, D L, Saussy, S M, Spaethe, T, Goodson, D K, Herron, J H, Fleisch   +8 more
openaire   +2 more sources

Development and application of a membrane receptor assay for leukotriene B4

Agents and Actions, 1989
5(S),12(R)-dihydroxy-6-cis-8,10 trans-14-cis-eicosatetraenoic acid (LTB4) is a potent inflammatory mediator generated by human cells. A receptor assay using membranes from cultured HL-60 cells has been developed to quantitate LTB4 with a range of sensitivity from 10 pg to 5 ng.
D M, Patelunas, A P, Agins, R E, Zipkin, J B, Smith   +3 more
openaire   +2 more sources

Essential fatty acids are antagonists of the leukotriene B4 receptor

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1995
A series of essential fatty acids and fatty acid derivatives were evaluated for their ability to inhibit [3H] leukotriene B4 (LTB4) binding to pig neutrophil membranes. The fatty acids varied in chain length, extent of unsaturation, position of unsaturation, and isomerization.
K A, Yagaloff, L, Franco, B, Simko, B, Burghardt   +3 more
openaire   +2 more sources

Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones

Journal of Medicinal Chemistry, 1992
A series of hydroxyacetophenones was prepared for evaluation as leukotriene B4 (LTB4) receptor antagonists, culminating in 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5- yl)heptyl]oxy]phenyl]ethanone (compound 35, LY255283). Using an assay for inhibition of specific [3H]LTB4 binding to human PMN, we found that substitution of a nonpolar ...
D K, Herron, T, Goodson, N G, Bollinger, D, Swanson-Bean, I G, Wright, G S, Staten, A R, Thompson, L L, Froelich, W T, Jackson   +8 more
openaire   +2 more sources