Results 111 to 120 of about 17,556 (218)

Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells [PDF]

, 2016
Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport ...
Castro, Guillermo Raul, Grumelli, Sandra, Islan, German Abel   +2 more
core   +1 more source

Stimulation of cyclic AMP production in human alveolar macrophages induced by inflammatory mediators and β-sympathicomimetics [PDF]

, 1992
We have investigated the effects of inflammatory mediators and β-adrenoceptor agonists on the adenylyl cyclase responsiveness in alveolar macrophages from control subjects, patients suffering from chronic obstructive pulmonary disease (COPD) and ...
Amsterdam, J.G.C. (Jan) van, Beusenberg, F.D., Bonta, I.L., Brouwers, J.W., Hekking, P.R.M. (P. R M), Hoogsteden, H.C. (Henk), Schermers, H.P. (H.)   +6 more
core   +1 more source

Alpha-Lipoic Acid-Mediated Inhibition of LTB4 Synthesis Suppresses Epithelial-Mesenchymal Transition, Modulating Functional and Tumorigenic Capacities in Non-Small Cell Lung Cancer A549 Cells

Current Therapeutic Research
Background: Leukotriene B4 (LTB4) plays a crucial role in carcinogenesis by inducing epithelial-mesenchymal transition (EMT), a process associated with tumor progression. The synthesis of LTB4 is mediated by leukotriene A4 hydrolase (LTA4H), and it binds
María José Torres, PhD, Juan Carlos Ríos, PhD, Alexandra Valle, MSc, Sebastián Indo, PhD, Kevin Brockway GV, MSc, Fernanda López-Moncada, PhD, Mario Faúndez, PhD, Enrique A. Castellón, PhD, Héctor R. Contreras, PhD   +8 more
doaj   +1 more source

Systemic leukotriene B₄ receptor antagonism lowers arterial blood pressure and improves autonomic function in the spontaneously hypertensive rat [PDF]

, 2016
KEY POINTS: Evidence indicates an association between hypertension and chronic systemic inflammation in both human hypertension and experimental animal models.
Cruise, Tom, DeCicco, Danielle, Hendy, Emma, Marvar, Paul, Murphy, David, Paton, Julian F R, Schwaber, James, Vadigepalli, Rajanikanth, Waki, Hidefumi, Walas, Dawid   +9 more
core   +2 more sources

Composition of fatty acids in plasma and erythrocytes and eicosanoids level in patients with metabolic syndrome [PDF]

, 2011
Background Disturbances of the fatty acids composition in plasma and red blood cells and eicosanoid synthesis play an important role in the metabolic syndrome (MS) formation.
Tatyana P Novgorodtseva, Yulia K Karaman, Natalia V Zhukova, Elena G Lobanova, Marina V Antonyuk, Tatyana A Kantur   +5 more
core   +1 more source

The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage [PDF]

, 2001
OBJECTIVE: Eicosanoids have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Leukotrienes, 5-hydroxyperoxyeicosatetraenoic acid, and 5-hydroxyeicosatetraenoic acid are part of this group of substances ...
Arthur, AS, Barbosa, MD, Gazak, C, Kassell, NF, Louis, RH, MacDonald, T, Polin, RS   +6 more
core   +1 more source

Study on the effect and mechanism of Ershiyiwei Lvronghao concentrated Pills in the treatment of nonalcoholic fatty liver disease

Frontiers in Pharmacology
BackgroundErshiyiwei Lvronghao Concentrated Pills (ESYWLRHW) is the concentrated pill developed and prepared based on the classical prescription in Xizang: Ershiwuwei Lvronghao Pills (ESWWLRHW).
Yexin Wu, Bin Chen, Jintao Long, Mingxin Pai, Zhiyong Xiao, Qun Huang, Kang Li, Bengui Ye, Bengui Ye   +8 more
doaj   +1 more source

A Novel Hepatointestinal Leukotriene B4 Receptor [PDF]

Journal of Biological Chemistry, 2000
Suke Wang, Eric Gustafson, Ling Pang, Xudong Qiao, Jiang Behan, Maureen Maguire, Marvin Bayne, Thomas Laz   +7 more
openaire   +1 more source

Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation

Journal of Biological Chemistry
Chronic inflammation is the underlying cause of many diseases, including type 1 diabetes, obesity, and non-alcoholic fatty liver disease. Macrophages are continuously recruited to tissues during chronic inflammation where they exacerbate or resolve the pro-inflammatory environment.
Ebru Ermis, Titli Nargis, Kierstin Webster, Sarah A. Tersey, Ryan M. Anderson, Raghavendra G. Mirmira   +5 more
openaire   +2 more sources

Leukotriene B4 (LTB4); leukotriene B4 type 1 receptor (LTB4R; BLT1); leukotriene B4 type 2 receptor (LTB4R2; BLT2) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source