Results 141 to 150 of about 9,646 (180)

Distribution of leukotriene B4 receptors in human hematopoietic cells

Immunopharmacology, 2000
Leukotriene B4 (LTB4), a product of arachidonic acid metabolism, plays an important role in inflammatory responses. We have cloned from human erythroleukemia cells, a G protein-coupled receptor, designated P2Y(7), which was later identified as the receptor for LTB4 (B-LTR).
V R, Dasari, J, Jin, S P, Kunapuli
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BLT2, a Second Leukotriene B4 Receptor

2001
Leukotriene B4 (LTB4) is a potent chemoattractant and activator for granulocytes and macrophages [1–3]. The high-affinity receptor for LTB4 (BLT1) was cloned and shown to be a G-protein-coupled receptor (GPCR) with low structural homology to the other known GPCRs [4]. Here we report a second LTB4 receptor, BLT2, found in a gene cluster with BLT1 [5,6].
Takehiko Yokomizo, Kazuhiko Kato, Kan Terawaki, Takashi Izumi, Takao Shimizu   +4 more
openaire   +1 more source

Detergent solubilization of human neutrophil leukotriene B4 receptors

Biochemical and Biophysical Research Communications, 1985
Specific leukotriene B4 (LTB4) receptors in human neutrophils were solubilized by treatment of "receptor fraction" membranes with the zwitterionic detergent (3-[(3-cholamidopropyl)-dimethylammonio]1-propane sulfonate (CHAPS). The soluble receptors were assayed by polyethylene glycol (PEG) precipitation coupled with Millipore filtration. The solubilized
A H, Lin, P L, Ruppel, R R, Gorman
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Analogs of leukotriene B4: Effects of modification of the hydroxyl groups on leukocyte aggregation and binding to leukocyte leukotriene B4 receptors

Prostaglandins, 1987
The syntheses and agonist and binding activities of 5(S)-hydroxy- 6(Z), 8(E), 10(E), 14(Z)-eicosatetraenoic acid (12-deoxy LTB4), 5(S), 12(S)-dihydroxy-6(Z), 8(E), 10(E), 14(Z)-eicosatetraenoic acid (12-epi LTB4), 12(R)-hydroxy-6(Z), 8(E), 10(E), 14(Z)-eicosatetraenoic acid (5-deoxy LTB4), 5(R), 12(S)-dihydroxy-6(Z), 8(E), 10(E), 14(Z)-eicosatetraenoic
Y, Leblanc, B J, Fitzsimmons, S, Charleson, P, Alexander, J F, Evans, J, Rokach   +5 more
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Up-Regulated Membrane and Nuclear Leukotriene B4 Receptors in COPD

Chest, 2006
We investigated the role of two leukotriene B4 (LTB4) receptors, BLT1 and peroxisome proliferator-activated receptor (PPAR)-alpha, in conferring the susceptibility to develop COPD in smokers. Proinflammatory LTB4 activities are mediated by BLT1, while the inactivation of LTB4 is promoted by PPARalpha.BLT1 and PPARalpha proteins were quantified by ...
MARIAN E, BARALDO, SIMONETTA, VISENTIN, ANNALISA, PAPI A, SAETTA, MARINA, FABBRI LM, MAESTRELLI, PIERO   +6 more
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Regulation of the production (leukotriene A4 hydrolase) and the action (leukotriene B4 receptor sites) of leukotriene B4

1987
Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism derived through the action of the 5-lipoxygenase pathway. The end product of the 5-lipoxygenase reaction, LTA4, is converted by a specific enzyme, leukotriene A4 hydrolase, to LTB4 (5[S],12[R]-dihydroxy 6,14-cis-8,10-trans eicosatetraenoic acid).
openaire   +1 more source

Leukotriene B4 receptors: Novel roles in immunological regulations

Advances in Enzyme Regulation, 2011
Mammals have at least two receptors for LTB4; high-affinity BLT1 and low-affinity BLT2, both of which are GPCRs. 12-HHT serves as a more potent and abundant ligand for BLT2 than LTB4. BLT1 is expressed in a variety of inflammatory and immune cells including granulocytes, eosinophils, macrophages, differentiated Th1, Th2 and Th17 cells, effecter CD8+ T ...
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BLT1 and BLT2: the leukotriene B4 receptors

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2003
Two receptors for leukotriene B(4) (LTB(4)) have been molecularly identified: BLT1 and BLT2. Both receptors are G protein-coupled seven transmembrane domain receptors, whose genes are located in very close proximity to each other in the human and mouse genomes.
Andrew M, Tager, Andrew D, Luster
openaire   +2 more sources

Functional properties of guinea pig eosinophil leukotriene B4 receptor

The Journal of Immunology, 1991
Abstract It is currently thought that pulmonary eosinophils play a proinflammatory role in bronchial asthma. Leukotriene B4 (LTB4) is being considered as an important mediator in regulating eosinophil function because of its potent activities in inducing leukocyte chemotaxis, chemokinesis, degranulation, and aggregation. Because the LTB4
C F, Ng, F F, Sun, B M, Taylor, M S, Wolin, P Y, Wong   +4 more
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Leukotriene B4 (LTB4) Receptor Antagonists: A Series of (Hydroxyphenyl)pyrazoles

Journal of Medicinal Chemistry, 1994
A series of (hydroxyphenyl)pyrazoles was designed by molecular modeling comparison with the LTB4 structure and prepared for evaluation as LTB4 receptor antagonists, culminating in 4-ethyl-5-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]-2-(1H-pyrazol -3- yl)phenol (2).
R W, Harper, W T, Jackson, L L, Froelich, R J, Boyd, T E, Aldridge, D K, Herron   +5 more
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