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Role of Notch Receptors in Hematologic Malignancies [PDF]
Cells, 2020 Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five
Laura Gragnani +3 more
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Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis. [PDF]
Experimental Hematology, 2000 Hematopoiesis is the process by which mature blood cell types are generated from a small population of pluripotent hematopoietic stem cells. How these cells undergo fate selection, however, is not fully understood. The Notch signaling system is known to mediate cell fate decisions of multipotent precursors in a wide range of complex animals throughout ...
Nita Singh +4 more
semanticscholar +3 more sources
Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy, 2022 The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Kongming Wu, Qian Chu
exaly +2 more sources
Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling [PDF]
Journal of Cell Biology, 2015 COMMD protein family member COMMD9 regulates the endosome to plasma membrane trafficking of Notch through a unique COMMD–CCDC22–CCDC93 (CCC) complex.
Haiying Li +13 more
semanticscholar +8 more sources
Therapeutic antibody targeting of individual Notch receptors [PDF]
Nature, 2010 The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to regulate cell fate and growth. Ligand binding triggers a conformational change in the receptor negative regulatory region (NRR) that enables ADAM protease cleavage at a juxtamembrane site that ...
Yan Wu +23 more
semanticscholar +3 more sources
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases
Frontiers in Immunology, 2021 The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in theory are attractive, their design and implementation ...
Panagiotis F. Christopoulos +8 more
doaj +2 more sources
The Role of Notch Receptors in Transcriptional Regulation [PDF]
Journal of Cellular Physiology, 2015 Notch signaling has pleiotropic context‐specific functions that have essential roles in many processes, including embryonic development and maintenance and homeostasis of adult tissues. Aberrant Notch signaling (both hyper‐ and hypoactive) is implicated in a number of human developmental disorders and many cancers.
Hongfang Wang, C. Zang, X. Liu, J. Aster
semanticscholar +3 more sources
A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers.
PLoS Computational Biology, 2023 All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the Notch signal
Daipeng Chen +5 more
doaj +5 more sources
The Notch Pathway in Breast Cancer Progression
The Scientific World Journal, 2018 Objective. Notch signaling pathway is a vital parameter of the mammalian vascular system. In this review, the authors summarize the current knowledge about the impact of the Notch signaling pathway in breast cancer progression and the therapeutic role of
Emmanuel N. Kontomanolis +6 more
doaj +2 more sources
The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation [PDF]
Biomolecules, 2021 Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limited ...
Judith Hounjet, Marc Vooijs
doaj +4 more sources