Results 11 to 20 of about 114,328 (209)

Notch receptor and Notch ligand expression in developing avian cartilage [PDF]

Journal of Anatomy, 2009
AbstractThe development of limb cartilage involves complex signalling pathways allowing the formation of distinct segments of cartilage that are maintained in the fully developed joint. In this study, we investigated the Notch signalling pathway and its role in cartilage development.
Rebecca, Williams, Larissa, Nelson, Gary P, Dowthwaite, Darrell J R, Evans, Charles W, Archer   +4 more
openaire   +2 more sources

Human Ligands of the Notch Receptor [PDF]

The American Journal of Pathology, 1999
During development, the Notch signaling pathway is essential for the appropriate differentiation of many cell types in organisms across the phylogenetic scale, including humans. Notch signaling is also implicated in human diseases, including a leukemia and two hereditary syndromes known as Alagille and CADASIL.
G E, Gray, R S, Mann, E, Mitsiadis, D, Henrique, M L, Carcangiu, A, Banks, J, Leiman, D, Ward, D, Ish-Horowitz, S, Artavanis-Tsakonas   +9 more
openaire   +2 more sources

NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells

Cells, 2020
The NOTCH family of receptors and ligands is involved in numerous cell differentiation processes, including adipogenesis. We recently showed that overexpression of each of the four NOTCH receptors in 3T3-L1 preadipocytes enhances adipogenesis and ...
María-Milagros Rodríguez-Cano, María-Julia González-Gómez, Beatriz Sánchez-Solana, Eva-María Monsalve, María-José M. Díaz-Guerra, Jorge Laborda, María-Luisa Nueda, Victoriano Baladrón   +7 more
doaj   +1 more source

Recent advances in in situ Notch signaling measurement

Frontiers in Cell and Developmental Biology, 2023
Notch signaling is necessary for the development of many organ systems, including the nervous system, biliary system, and visual and auditory sensory systems. This signaling pathway is composed of DSL ligands and Notch receptors.
Masaharu Yoshihara, Satoru Takahashi, Satoru Takahashi   +2 more
doaj   +1 more source

Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers

Molecules, 2021
Notch signaling receptors, ligands, and their downstream target genes are dysregulated in pancreatic ductal adenocarcinoma (PDAC), suggesting a role of Notch signaling in pancreatic tumor development and progression.
Rashu Barua, Kazuyuki Mizuno, Yuko Tashima, Mitsutaka Ogawa, Hideyuki Takeuchi, Ayumu Taguchi, Tetsuya Okajima   +6 more
doaj   +1 more source

Notch Receptor Activation Inhibits Oligodendrocyte Differentiation [PDF]

Neuron, 1998
In this study, we show that oligodendrocyte differentiation is powerfully inhibited by activation of the Notch pathway. Oligodendrocytes and their precursors in the developing rat optic nerve express Notch1 receptors and, at the same time, retinal ganglion cells express Jagged1, a ligand of the Notch1 receptor, along their axons.
Wang, Songli, Sdrulla, Andrei D, diSibio, Guy, Bush, Gay, Nofziger, Donna, Hicks, Carol, Weinmaster, Gerry, Barres, Ben A   +7 more
openaire   +2 more sources

Synergistic regulation of Notch signaling by different O-glycans promotes hematopoiesis

Frontiers in Immunology, 2023
Glycosylation of Notch receptors by O-fucose glycans regulates Notch ligand binding and Notch signaling during hematopoiesis. However, roles in hematopoiesis for other O-glycans that modify Notch receptors have not been determined.
Ankit Tanwar, Pamela Stanley
doaj   +1 more source

Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis [PDF]

Experimental Hematology, 2000
Hematopoiesis is the process by which mature blood cell types are generated from a small population of pluripotent hematopoietic stem cells. How these cells undergo fate selection, however, is not fully understood. The Notch signaling system is known to mediate cell fate decisions of multipotent precursors in a wide range of complex animals throughout ...
N, Singh, R A, Phillips, N N, Iscove, S E, Egan   +3 more
openaire   +2 more sources

Notching tumor: Signaling through Notch receptors improves antitumor T cell immunity [PDF]

OncoImmunology, 2016
Notch signaling is crucial for lymphocyte effector and memory differentiation. While tumor suppress Notch signaling in antitumor lymphocytes, recent studies show that the pharmacological Delta-like ligand-1 multivalent cluster or proteasome inhibitor bortezomib can restore Notch-NF-κB signaling in T cells of tumor-bearing hosts with a potential to ...
Roman, Uzhachenko, Anil, Shanker
openaire   +2 more sources

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]

, 2015
In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano, De Falco, Filomena, Del Papa, Beatrice, Di Ianni, Mauro, Falzetti, Franca, Marconi, Pierfrancesco, Rosati, Emanuela, Sabatini, Rita, Screpanti, Isabella, Sportoletti, Paolo   +9 more
core   +7 more sources