Results 11 to 20 of about 2,492,882 (302)

Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors [PDF]

Molecular and Cellular Biology, 2000
Notch receptors participate in a highly conserved signaling pathway that regulates morphogenesis in multicellular animals. Maturation of Notch receptors requires the proteolytic cleavage of a single precursor polypeptide to produce a heterodimer composed of a ligand-binding extracellular domain (N(EC)) and a single-pass transmembrane signaling domain ...
M. Rand, L. Grimm, S. Artavanis-Tsakonas, V. Patriub, S. Blacklow, J. Sklar, J. Aster   +6 more
semanticscholar   +3 more sources

Notch signaling in cancer: metabolic reprogramming and therapeutic implications [PDF]

Frontiers in Immunology
The evolutionarily conserved Notch signaling pathway is essential for cell-fate determination, organogenesis, and tissue homeostasis. Notch receptors and their ligands are transmembrane proteins with epidermal growth factor–like repeats; ligand–receptor ...
Shuang-Shuang Wang, Shuang-Shuang Wang, Shuang-Shuang Wang, Hui-Lin Lv, Hui-Lin Lv, Hui-Lin Lv, Rong-Zu Nie, Rong-Zu Nie, Rong-Zu Nie, Ya-Ping Liu, Ya-Ping Liu, Ya-Ping Liu, Yan-Jie Hou, Yan-Jie Hou, Yan-Jie Hou, Chen Chen, Chen Chen, Chen Chen, Xing-Yue Tao, Xing-Yue Tao, Xing-Yue Tao, Huo-Min Luo, Huo-Min Luo, Huo-Min Luo, Pei-Feng Li, Pei-Feng Li, Pei-Feng Li   +26 more
doaj   +2 more sources

Literature review of Notch melanoma receptors

Surgical and Experimental Pathology, 2019
Despite the immunotherapeutics and target therapy agents, the survival of patients with advanced melanoma is still low. Notch signaling is able to regulate many aspects of melanomagenesis.
Renato Santos de Oliveira Filho, Alexandre Lavorato Soares, Francisco Macedo Paschoal, Gisele Gargantini Rezze, Ebe Oliveira, Ricardo Macarenco, Antonio Carlos Buzaid, Lydia Masako Ferreira   +7 more
doaj   +2 more sources

The Varied Roles of Notch in Cancer

Annual Review of Pathology: Mechanisms of Disease, 2017
Jon C Aster, Warren S Pear, Stephen C Blacklow   +2 more
exaly   +2 more sources

Development and validation of an immune infiltration/tumor proliferation-related Notch3 nomogram for predicting survival in patients with primary glioblastoma

Frontiers in Genetics, 2023
Background: Notch receptors (Notch 1/2/3/4), the critical effectors of the Notch pathway, participate in the tumorigenesis and progression of many malignancies.
Zong-Qing Zheng, Guo-Guo Zhang, Gui-Qiang Yuan, Jia-Hui Hao, Qian-Qian Nie, Ming-Cheng Zheng, Zhong Wang   +6 more
doaj   +1 more source

Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions

Biomolecules, 2021
The 100th anniversary of Notch discovery in Drosophila has recently passed. The Notch is evolutionarily conserved from Drosophila to humans. The discovery of human-specific Notch genes has led to a better understanding of Notch signaling in development ...
Wataru Saiki, Chenyu Ma, Tetsuya Okajima, Hideyuki Takeuchi   +3 more
doaj   +1 more source

Significant Roles of Notch O-Glycosylation in Cancer

Molecules, 2022
Notch signaling, which was initially identified in Drosophila wing morphogenesis, plays pivotal roles in cell development and differentiation. Optimal Notch pathway activity is essential for normal development and dysregulation of Notch signaling leads ...
Weiwei Wang, Tetsuya Okajima, Hideyuki Takeuchi   +2 more
doaj   +1 more source

A spatially defined human Notch receptor interaction network reveals Notch intracellular storage and Ataxin-2-mediated fast recycling

Cell Reports, 2023
Summary: The Notch signaling pathway controls cell growth, differentiation, and fate decisions. Dysregulation of Notch signaling has been linked to various human diseases.
Weixiang Bian, Hua Jiang, Luxia Yao, Wanyu Hao, Lianfeng Wu, Xu Li   +5 more
doaj   +1 more source

Engagement of TLR and Dectin-1/Syk Signaling Is Required for Activation of Notch Targets in Dendritic Cells

Infectious Microbes & Diseases, 2021
. Pattern-recognition receptors, such as toll-like receptors (TLRs), detect a wide range of microbial products and initiate innate immune responses leading to the production of inflammatory mediators.
Yuna Zhao, Chanyang Ju, Karmen Au, Jimmy Zhu, Baohong Zhao, Yingli Shang, Xiaoyu Hu, Fudi Wang   +7 more
doaj   +1 more source

Notch receptor and Notch ligand expression in developing avian cartilage [PDF]

Journal of Anatomy, 2009
AbstractThe development of limb cartilage involves complex signalling pathways allowing the formation of distinct segments of cartilage that are maintained in the fully developed joint. In this study, we investigated the Notch signalling pathway and its role in cartilage development.
Rebecca, Williams, Larissa, Nelson, Gary P, Dowthwaite, Darrell J R, Evans, Charles W, Archer   +4 more
openaire   +2 more sources