Results 21 to 30 of about 2,492,882 (302)
Human Ligands of the Notch Receptor [PDF]
The American Journal of Pathology, 1999 During development, the Notch signaling pathway is essential for the appropriate differentiation of many cell types in organisms across the phylogenetic scale, including humans. Notch signaling is also implicated in human diseases, including a leukemia and two hereditary syndromes known as Alagille and CADASIL.
G E, Gray +9 more
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NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells
Cells, 2020 The NOTCH family of receptors and ligands is involved in numerous cell differentiation processes, including adipogenesis. We recently showed that overexpression of each of the four NOTCH receptors in 3T3-L1 preadipocytes enhances adipogenesis and ...
María-Milagros Rodríguez-Cano +7 more
doaj +1 more source
Recent advances in in situ Notch signaling measurement
Frontiers in Cell and Developmental Biology, 2023 Notch signaling is necessary for the development of many organ systems, including the nervous system, biliary system, and visual and auditory sensory systems. This signaling pathway is composed of DSL ligands and Notch receptors.
Masaharu Yoshihara +2 more
doaj +1 more source
Notch Receptor Activation Inhibits Oligodendrocyte Differentiation [PDF]
Neuron, 1998 In this study, we show that oligodendrocyte differentiation is powerfully inhibited by activation of the Notch pathway. Oligodendrocytes and their precursors in the developing rat optic nerve express Notch1 receptors and, at the same time, retinal ganglion cells express Jagged1, a ligand of the Notch1 receptor, along their axons.
Wang, Songli +7 more
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Molecules, 2021 Notch signaling receptors, ligands, and their downstream target genes are dysregulated in pancreatic ductal adenocarcinoma (PDAC), suggesting a role of Notch signaling in pancreatic tumor development and progression.
Rashu Barua +6 more
doaj +1 more source
Synergistic regulation of Notch signaling by different O-glycans promotes hematopoiesis
Frontiers in Immunology, 2023 Glycosylation of Notch receptors by O-fucose glycans regulates Notch ligand binding and Notch signaling during hematopoiesis. However, roles in hematopoiesis for other O-glycans that modify Notch receptors have not been determined.
Ankit Tanwar, Pamela Stanley
doaj +1 more source
Relevance of Notch Signaling for Bone Metabolism and Regeneration
International Journal of Molecular Sciences, 2021 Notch1-4 receptors and their signaling pathways are expressed in almost all organ systems and play a pivotal role in cell fate decision by coordinating cell proliferation, differentiation and apoptosis.
T. Ballhause +7 more
semanticscholar +1 more source
Notching tumor: Signaling through Notch receptors improves antitumor T cell immunity [PDF]
OncoImmunology, 2016 Notch signaling is crucial for lymphocyte effector and memory differentiation. While tumor suppress Notch signaling in antitumor lymphocytes, recent studies show that the pharmacological Delta-like ligand-1 multivalent cluster or proteasome inhibitor bortezomib can restore Notch-NF-κB signaling in T cells of tumor-bearing hosts with a potential to ...
Roman, Uzhachenko, Anil, Shanker
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Reduced Notch signalling leads to postnatal skeletal muscle hypertrophy in Pofut1cax/cax mice [PDF]
Open Biology, 2016 Postnatal skeletal muscle growth results from the activation of satellite cells and/or an increase in protein synthesis. The Notch signalling pathway maintains satellite cells in a quiescent state, and once activated, sustains their proliferation and ...
Bilal Al Jaam +8 more
doaj +1 more source
Diversity in Notch ligand-receptor signaling interactions
eLife, 2023 Abstract The Notch signaling pathway uses families of ligands and receptors to transmit signals to nearby cells. These components are expressed in diverse combinations in different cell types, interact in a many-to-many fashion, both within the same cell (in cis) and between cells (in trans), and their interactions are modulated by ...
Rachael Kuintzle +2 more
openaire +4 more sources