Results 31 to 40 of about 114,328 (209)
The NOTCH receptor and its ligands
Trends in Cell Biology, 1997 An intricate interplay of signalling pathways dictates the acquisition of specific cell fates during development. The NOTCH receptor is the central element in a cell-interaction mechanism that controls the fate of a very broad spectrum of precursor cells.
R J, Fleming +2 more
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NOTCH activation promotes glycosyltransferase expression in human myeloid leukemia cells
Hematology Reports, 2018 NOTCH signaling diversely regulates the growth of acute myeloid leukemia (AML) cells. It is known that glycosylation of NOTCH receptors modulates NOTCH activation. However, little is known about glycosylation of NOTCH in AML cells.
Shichun Wang +4 more
doaj +1 more source
Surgical and Experimental Pathology, 2020 Background The Notch signaling pathway and its modulators are directly related to growth, verticalization and metastasis in melanoma, being a possible therapeutic target for the treatment of this type of cancer.
Lorena Dal Collina Sangiuliano +4 more
doaj +1 more source
Nature Communications, 2021 Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell ...
Sushil Kumar +12 more
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Targeting self-renewal pathways in myeloid malignancies [PDF]
, 2013 A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core +2 more sources
No evidence for a functional role of bi-directional Notch signaling during angiogenesis. [PDF]
PLoS ONE, 2012 The Delta-Notch pathway is a signal exchanger between adjacent cells to regulate numerous differentiation steps during embryonic development. Blood vessel formation by sprouting angiogenesis requires high expression of the Notch ligand DLL4 in the ...
Sven S Liebler +5 more
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RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]
, 2016 Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia +16 more
core +1 more source
Therapeutic antibody targeting of individual Notch receptors [PDF]
Nature, 2010 The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to regulate cell fate and growth. Ligand binding triggers a conformational change in the receptor negative regulatory region (NRR) that enables ADAM protease cleavage at a juxtamembrane site that ...
Yan, Wu +23 more
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Notch Ligand Binding Assay Using Flow Cytometry
Bio-Protocol, 2017 Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013).
Shweta Varshney, Pamela Stanley
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BMC Cancer, 2022 Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal development and plays a crucial role in breast ...
Hassan Yousefi +13 more
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