Results 31 to 40 of about 2,492,882 (302)
NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies
Frontiers in Immunology, 2018 The NOTCH (1–4) family of receptors are highly conserved and are critical in regulating many developmental processes and in the maintenance of tissue homeostasis.
Michelle A. Kelliher +1 more
doaj +1 more source
Nuclear receptor regulation gears up another Notch [PDF]
Nuclear Receptor Signaling, 2006 In this perspective we describe examples of crosstalk between nuclear receptors (NRs) and Notch signaling by means of direct functional interactions between components of both pathways. This crosstalk may provide eukaryotic organisms with molecular mechanisms for the coordination of llong-distance endocrine signals with cell-to-cell juxtacrine ...
Belandia, Borja, Parker, Malcolm G.
openaire +3 more sources
A toolkit for studying cell surface shedding of diverse transmembrane receptors
eLife, 2019 Proteolysis of transmembrane receptors is a critical cellular communication mechanism dysregulated in disease, yet decoding proteolytic regulation mechanisms of hundreds of shed receptors is hindered by difficulties controlling stimuli and unknown fates ...
Amanda N Hayward +2 more
doaj +1 more source
Expression of Notch receptors and their ligands in pancreatic ductal adenocarcinoma
Experimental and Therapeutic Medicine, 2018 Pancreatic cancer is the fourth leading cause of cancer-associated mortality in developed countries. Pancreatic ductal adenocarcinoma (PDAC) accounts for ~90% of all pancreatic cancer cases.
Hai-yan Song +3 more
semanticscholar +1 more source
NOTCH activation promotes glycosyltransferase expression in human myeloid leukemia cells
Hematology Reports, 2018 NOTCH signaling diversely regulates the growth of acute myeloid leukemia (AML) cells. It is known that glycosylation of NOTCH receptors modulates NOTCH activation. However, little is known about glycosylation of NOTCH in AML cells.
Shichun Wang +4 more
doaj +1 more source
NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?
Molecular Cancer, 2016 Gastric cancer (GC) ranks the most common cancer types and is one of the leading causes of cancer-related death. Due to delayed diagnosis and high metastatic frequency, 5-year survival rate of GC is rather low.
Tingting Huang +5 more
semanticscholar +1 more source
A Review on Notch Signaling and Colorectal Cancer
Cells, 2020 Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of treatment options. Aggressive CRC remains difficult to treat owing to the activation of oncogenic signaling pathways such as the Notch signaling pathway.
A. Tyagi, Arun K. Sharma, C. Damodaran
semanticscholar +1 more source
The NOTCH receptor and its ligands
Trends in Cell Biology, 1997 An intricate interplay of signalling pathways dictates the acquisition of specific cell fates during development. The NOTCH receptor is the central element in a cell-interaction mechanism that controls the fate of a very broad spectrum of precursor cells.
R J, Fleming +2 more
openaire +2 more sources
Surgical and Experimental Pathology, 2020 Background The Notch signaling pathway and its modulators are directly related to growth, verticalization and metastasis in melanoma, being a possible therapeutic target for the treatment of this type of cancer.
Lorena Dal Collina Sangiuliano +4 more
doaj +1 more source
Clinical Cancer Research, 2015 Purpose: To identify and characterize novel, activating mutations in Notch receptors in breast cancer and to determine response to the gamma secretase inhibitor (GSI) PF-03084014.
Kai Wang +12 more
semanticscholar +1 more source