Results 41 to 50 of about 2,492,882 (302)
Nature Communications, 2021 Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell ...
Sushil Kumar +12 more
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Notch Ligand Binding Assay Using Flow Cytometry
Bio-Protocol, 2017 Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013).
Shweta Varshney, Pamela Stanley
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No evidence for a functional role of bi-directional Notch signaling during angiogenesis. [PDF]
PLoS ONE, 2012 The Delta-Notch pathway is a signal exchanger between adjacent cells to regulate numerous differentiation steps during embryonic development. Blood vessel formation by sprouting angiogenesis requires high expression of the Notch ligand DLL4 in the ...
Sven S Liebler +5 more
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Notch receptors in GtoPdb v.2021.2
IUPHAR/BPS Guide to Pharmacology CITE, 2021 Aberrant Notch signalling is implicated in a number of human cancers [18, 26, 13, 21], and there is intense pharmaceutical activity being directed towards achieving clinically effective Notch pathway inhibition [7, 16].
Christopher Sobey, Thiruma V. Arumugam
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BMC Cancer, 2022 Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal development and plays a crucial role in breast ...
Hassan Yousefi +13 more
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Cells, 2020 Evolutionarily conserved Notch plays a critical role in embryonic development and cellular self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is widely described.
G. Moore +3 more
semanticscholar +1 more source
eLife, 2017 The glycosyltransferase EOGT transfers O-GlcNAc to a consensus site in epidermal growth factor-like (EGF) repeats of a limited number of secreted and membrane proteins, including Notch receptors. In EOGT-deficient cells, the binding of DLL1 and DLL4, but
Shogo Sawaguchi +10 more
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Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. [PDF]
PLoS ONE, 2011 The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1 ...
Jon C Aster +9 more
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Notch Signaling in Breast Cancer: A Role in Drug Resistance
Cells, 2020 Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2.
M. BeLow, C. Osipo
semanticscholar +1 more source
Regulation of myeloid and lymphoid cell development by O-glycans on Notch
Frontiers in Molecular Biosciences, 2022 Notch signaling via NOTCH1 stimulated by Delta-like ligand 4 (DLL4) is required for the development of T cells in thymus, and NOTCH2 stimulated by Notch ligand DLL1 is required for the development of marginal zone (MZ) B cells in spleen.
Pamela Stanley, Ankit Tanwar
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