Results 51 to 60 of about 2,492,882 (302)
Mammalian NOTCH Receptor Activation and Signaling Protocols
, 2022 The NOTCH signaling pathway is one of the highly conserved key pathways involved in most cell differentiation and proliferation processes during both developmental and adult stages in most animals. The NOTCH signaling pathway appears to be very simple but the existence of several receptors and ligands, their posttranslational modifications, their ...
Nueda Sanz, María Luisa +1 more
openaire +3 more sources
BMC Research Notes, 2023 The biliary epithelial cells (cholangiocytes) in the liver originate from undifferentiated liver parenchymal cells (hepatoblasts) that are located adjacent to the portal vein. This differentiation process is driven by Notch signaling, which is recognized
Masaharu Yoshihara +2 more
doaj +1 more source
Notching on cancer’s door: Notch signaling in brain tumors
Frontiers in Oncology, 2015 Notch receptors play an essential role in the regulation of central cellular processes during embryonic and postnatal development. The mammalian genome encodes for four Notch paralogs (Notch 1-4), which are activated by three Delta-like (Dll1/3/4) and ...
Marcin eTeodorczyk, Mirko HH Schmidt
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Precision medicine for human cancers with Notch signaling dysregulation (Review)
International Journal of Molecular Medicine, 2019 NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta-like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2.
Masuko Katoh, M. Katoh
semanticscholar +1 more source
Notch2 and Notch3 function together to regulate vascular smooth muscle development. [PDF]
PLoS ONE, 2012 Notch signaling has been implicated in the regulation of smooth muscle differentiation, but the precise role of Notch receptors is ill defined. Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only ...
Qingqing Wang +3 more
doaj +1 more source
Mechanisms of Notch signaling: a simple logic deployed in time and space
Development, 2019 Most cells in our body communicate during development and throughout life via Notch receptors and their ligands. Notch receptors relay information from the cell surface to the genome via a very simple mechanism, yet Notch plays multiple roles in ...
D. Henrique, F. Schweisguth
semanticscholar +1 more source
ACS Nano, 2020 Triple-negative breast cancer (TNBC) accounts for nearly one-quarter of all breast cancer cases, but effective targeted therapies for this disease remain elusive because TNBC cells lack expression of the three most common receptors seen on other subtypes
Danielle M. Valcourt +3 more
semanticscholar +1 more source
Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis
Molecular Cancer, 2009 Background Recent studies have implicated aberrant Notch signaling in breast cancers. Yet, relatively little is known about the pattern of expression of various components of the Notch pathway, or its mechanism of action. To better understand the role of
Dey Devaveena +4 more
doaj +1 more source
Cells, 2022 Photon-based radiotherapy upregulates Notch signaling in cancer, leading to the acquisition of the stem cell phenotype and induction of invasion/migration, which contributes to the development of resistance to therapy.
Vivek Kumar +6 more
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Role of Notch Signaling Pathway in Glioblastoma Pathogenesis
Cancers, 2019 Notch signaling is an evolutionarily conserved pathway that regulates important biological processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation. In mammals, Notch signaling is composed of four receptors (Notch1–4)
R. Bazzoni, A. Bentivegna
semanticscholar +1 more source