Results 11 to 20 of about 195,787 (262)
Pattern recognition receptors and autophagy [PDF]
Frontiers in Immunology, 2014 The immune system senses exogenous threats or endogenous stress through specialized machinery known as pattern recognition receptors (PRRs). These receptors recognize conserved molecular structures and initiate downstream signaling pathways to control ...
Ji Eun eOh, Heung Kyu eLee
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Pattern recognition receptors in HIV transmission [PDF]
Frontiers in Immunology, 2012 Dendritic cells (DCs), Langerhans cells (LCs) and macrophages are innate immune cells that reside in genital and intestinal mucosal tissues susceptible to HIV-1 infection.
Teunis B. Geijtenbeek, Annelies eMesman
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Pattern recognition receptors and gastric cancer [PDF]
Frontiers in Immunology, 2014 Chronic inflammation has been associated with an increased risk of several human malignancies, a classic example being gastric cancer (GC). Development of GC is known to result from infection of the gastric mucosa by Helicobacter pylori, which initially ...
Natalia eCastaño-Rodriguez +2 more
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Pattern recognition receptors in health and diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged senescent cells.
Danyang Li, Minghua Wu
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Identifying the Patterns of Pattern Recognition Receptors [PDF]
Immunity, 2018 Intestinal homeostasis requires microbial recognition that results in appropriate responses to commensals and pathogens. In this issue of Immunity, Price et al. (2018) map the in vivo expression of five toll-like receptors (TLR) in intestinal epithelia, revealing distinct spatio-temporal expression patterns that shape responses to TLR ligands.
Andrea A, Hill, Gretchen E, Diehl
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Anti-Viral Pattern Recognition Receptors as Therapeutic Targets
Cells, 2021 Pattern recognition receptors (PRRs) play a central role in the inflammation that ensues following microbial infection by their recognition of molecular patterns present in invading microorganisms but also following tissue damage by recognising molecules
Conor Hennessy, Declan P. McKernan
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Pattern recognition receptors as a double-edged sword in cancer
Frontiers in Immunology, 2015 The problem of cancer remains one of the most immense challenges to current biomedical research. Affecting populations in all countries and all regions, this disease is responsible for millions of deaths annually (1). Evasion of the immune system is an ominous feature of cancers, which often leads to tumor outgrowth, epithelial–mesenchymal transition ...
Anton G. Kutikhin, Arseniy E Yuzhalin
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Inhibitory pattern recognition receptors
Journal of Experimental Medicine, 2021 Pathogen- and damage-associated molecular patterns are sensed by the immune system’s pattern recognition receptors (PRRs) upon contact with a microbe or damaged tissue. In situations such as contact with commensals or during physiological cell death, the immune system should not respond to these patterns.
Matevž Rumpret +3 more
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Japanese Journal of Clinical Immunology, 2011 Immunity is based on self/nonself discrimination. In vertebrates, two major systems, innate and adaptive immune systems, constitute host defense against invading microbes. Adaptive immunity is characterized by specific immune responses through B- or T-cell antigen receptors that are generated by somatic recombination, whereas nonspecific responses to ...
Takaya, Hayashi +2 more
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Pattern-recognition receptors in endometriosis: A narrative review
Frontiers in Immunology, 2023 Endometriosis is closely associated with ectopic focal inflammation and immunosuppressive microenvironment. Multiple types of pattern recognition receptors (PRRs) are present in the innate immune system, which are able to detect pathogen-associated ...
Bao Guo +7 more
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