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PET Imaging of Purinergic Receptors
2020Over the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic receptors play key roles in physiological and pathological processes, although the exact role in these processes is not always fully understood.
Janssen, Bieneke +2 more
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Purinergic receptors in psychiatric disorders
Neuropharmacology, 2016Psychiatric disorders describe different mental or behavioral patterns, causing suffering or poor coping of ordinary life with manifold presentations. Multifactorial processes can contribute to their development and progression. Purinergic neurotransmission and neuromodulation in the brain have attracted increasing therapeutic interest in the field of ...
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The enteric purinergic P2Y1 receptor
Current Opinion in Pharmacology, 2006Significant recent discoveries have shown that the P2Y(1) purinergic receptor subtype is expressed in the enteric nervous system and at intestinal neuromuscular junctions. Secretomotor neurons, which release vasoactive intestinal peptide at their junctions with intestinal secretory glands, express the P2Y(1) receptor.
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Purinergic and Glutamatergic Receptors on Astroglia
2014Astroglial cells express many neurotransmitter receptors; the receptors to glutamate and ATP being the most abundant. Here, we provide a concise overview on the expression and main properties of astroglial glutamate receptors (ionotropic receptors represented by AMPA and NMDA subtypes) and metabotropic (mainly mGluR5 and mGluR3 subtypes) and ...
Verkhratsky, A, Burnstock, G
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Polish journal of pharmacology, 1997
The aim of the present paper was characterization of purinergic receptors specific for nucleotides (P2) and nucleosides (P1). Their subclassification, distribution and functions have been briefly described.
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The aim of the present paper was characterization of purinergic receptors specific for nucleotides (P2) and nucleosides (P1). Their subclassification, distribution and functions have been briefly described.
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Drooling Over Purinergic Receptors
Science Signaling, 2009ATP stimulates fluid secretion in mouse salivary glands through the P2X 7 receptor.
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Purinergic Receptor-Mediated Cytotoxicity
2006Mitochondria are vitally important for maintaining cellular integrity. Calcium is considered a mediator of necrosis as well as a main cause of damage in isolated mitochondria. Our results show that mitochondrial Ca2+ regulation in hepatocytes is affected when [Ca2+]i is increased; this is followed by mitochondrial dysfunction and irreversible cell ...
J. Fred Nagelkerke, J. Paul Zoeteweij
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Platelet ADP/Purinergic Receptors
1997Platelet aggregation by adenosine 5′-diphosphate (ADP) plays a key role in the development and extension of arterial thrombosis. ADP has also been implicated in vascular smooth muscle cell proliferation leading to restenosis at sites of vascular injury (Crowley et al. 1994).
C. Gachet, J.-P. Cazenave
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