Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity
Frontiers in Pharmacology, 2018 Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD+) are released as danger signals from cells during infection and sterile inflammation.
Stephan Menzel +3 more
doaj +1 more source
Differences in localization of P2X7 during epithelial wound healing in pre-type II diabetic models [PDF]
, 2017 Corneal injury, accompanied by improper wound repair, is the 4th highest cause of preventable blindness according to the World Health Organization.
Kneer, Krisandra
core
Frontiers in Pharmacology, 2018 Plasma levels of the vasoactive substance uridine adenosine tetraphosphate (Up4A) are elevated in hypertensive patients and Up4A-induced vascular contraction is exacerbated in various arteries isolated from hypertensive animals, suggesting a potential ...
Zhichao Zhou +13 more
doaj +1 more source
Antiplatelet Activity, P2Y1 and P2Y12 Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5′″-P1,P4-dithio-P2,P3-chloromethylenetetraphosphate [PDF]
, 2014 Background: Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation.
Barnard, Marc R. +8 more
core +3 more sources
Adenosine: Direct and Indirect Actions on Gastric Acid Secretion
Frontiers in Physiology, 2017 Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the metabolic and regulatory contexts.
Rosa M. Arin +5 more
doaj +1 more source
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation
Purinergic Signalling Purinergic Signalling, 2023 Seyed Hossein Kiaie +6 more
semanticscholar +1 more source
P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. [PDF]
, 2012 The P2X7 receptor is an ATP-gated non-selective cation-permeable ionotropic receptor selectively expressed in neurons and glia in the brain. Activation of the P2X7 receptor has been found to modulate neuronal excitability in the hippocampus and it has ...
Diaz-Hernandez, Miguel +4 more
core +2 more sources
Antidipsogenic effects of central adenosine-5'-triphosphate
Brazilian Journal of Medical and Biological Research, 2009 Besides other physiological functions, adenosine-5'-triphosphate (ATP) is also a neurotransmitter that acts on purinergic receptors. In spite of the presence of purinergic receptors in forebrain areas involved with fluid-electrolyte balance, the effect ...
D.R.G. de Faria +3 more
doaj
Macrophages in wound healing: activation and plasticity. [PDF]
, 2019 Macrophages are critically involved in wound healing, from dampening inflammation to clearing cell debris and coordinating tissue repair. Within the wound, the complexity of macrophage function is increasingly recognized, with adverse outcomes when ...
Kim, Sang Yong, Nair, Meera G
core