Results 61 to 70 of about 22,494 (202)

Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype: Implications for GI Infection, IBD, POI, Neurological, Motility, and GI Disorders [PDF]

, 2016
BACKGROUND: Clinical observations or animal studies implicate enteric glial cells in motility disorders, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal (GI) infections, postoperative ileus, and slow transit constipation ...
Abdel Rasoul, Mahmoud, Arsenescu, Razvan, Christofi, Fievos L., CUOMO, ROSARIO, Fadda, Paolo, Grants, Iveta, Harzman, Alan, Liñán Rico, Andromeda, Needleman, Bradley J, Ochoa Cortes, Fernando, TURCO, FABIO, Whitaker, Emmett   +11 more
core   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Development of the neurohypophysis: A major neuroendocrine interface

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract The neurohypophysis is a major central neuroendocrine interface regulating reproductive functions and water homeostasis. Distinct neurovascular cell types interact via evolutionarily conserved signaling molecules in the developing neurohypophysis, providing a model system for studying principles in neuroendocrine interface morphogenesis.
Athul R. Ramesh, Naveen Nedunchezhian, Md Hasan Ali, Sebastian Pęcherz, Natalia Kowalewska, Savani Anbalagan   +5 more
wiley   +1 more source

Purinergic Receptors in Ocular Inflammation

Mediators of Inflammation, 2014
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease.
Ana Guzman-Aranguez, Xavier Gasull, Yolanda Diebold, Jesús Pintor   +3 more
doaj   +1 more source

Role of adenosine A2a receptor in cancers and autoimmune diseases

Immunity, Inflammation and Disease, 2023
Adenosine receptors are P1 class of purinergic receptors that belong to G protein‐coupled receptors. There are 4 subtypes of adenosine receptors, namely A1, A2A, A2B, and A3. A2AR has a high affinity for the ligand adenosine.
Hongling Ye, Junqi Zhao, Xuejing Xu, Dagan Zhang, Han Shen, Sen Wang   +5 more
doaj   +1 more source

The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance [PDF]

, 2011
Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and characterized.
Robson, Simon Christopher, Sévigny, Jean, Zimmermann, Herbert   +2 more
core   +1 more source

Murine and Human-Purified very Small Embryonic-like Stem Cells (VSELs) Express Purinergic Receptors and Migrate to Extracellular ATP Gradient

Stem Cell Reviews and Reports
Purinergic signaling is an ancient primordial signaling system regulating tissue development and specification of various types of stem cells. Thus, functional purinergic receptors are present in several types of cells in the body, including multiple ...
K. Bujko, Katarzyna Brzeźniakiewicz-Janus, Justyna Jarczak, M. Kucia, Mariusz Z. Ratajczak   +4 more
semanticscholar   +1 more source

An emerging role for adenosine and its receptors in bone homeostasis

Frontiers in Endocrinology, 2012
Bone is continually being remodelled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodelling but other mechanisms, hitherto unknown, may also be involved.
Bronwen eEvans, Bronwen eEvans, Jack eHam, Jack eHam   +3 more
doaj   +1 more source

Adenosine pathway regulates inflammation during Plasmodium vivax infection

Frontiers in Immunology, 2023
BackgroundPlasmodium spp. infection triggers the production of inflammatory cytokines that are essential for parasite control, and conversely responsible for symptoms of malaria.
Suelen Queiroz Diniz, Suelen Queiroz Diniz, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Dhélio Batista Pereira, Mauro Shugiro Tada, Luis Carlos Crocco Afonso, Markus Kohlhoff, Carlos Leomar Zani, Ricardo Tostes Gazzinelli, Ricardo Tostes Gazzinelli, Fabiano Oliveira, Lis Ribeiro Antonelli, Lis Ribeiro Antonelli   +15 more
doaj   +1 more source

Mesenchymal Stem Cells Restore Endometrial Integrity and Sustain Pregnancy via CCR7‐ERK/JNK Signaling Modulation

Stem Cells International, Volume 2026, Issue 1, 2026.
Recurrent pregnancy loss (RPL), defined as more than two consecutive miscarriages before 20 weeks of gestation, affects 1%–5% of reproductive‐aged women, with nearly half of the cases remaining idiopathic. Using ethanol‐induced endometrial injury in rats to simulate RPL, we demonstrated that mesenchymal stem cells (MSCs) exert therapeutic effects ...
Yunguo Lei, Juanmei Gao, Ning Zhang, Yunjun Lin, Weihua Yang, Yuequn Chen, Qiang Wei, Jianmei Xia, Harleen Khatra   +8 more
wiley   +1 more source