Results 61 to 70 of about 7,951 (196)

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
wiley   +1 more source

Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites. [PDF]

, 2012
BACKGROUND: Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. METHODS: Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp ...
Blackman, Michael J, Budu, Alexandre, Cruz, Laura Nogueira, Garcia, Célia Rs, Holder, Anthony A, Juliano, Luiz, Juliano, Maria Aparecida   +6 more
core   +4 more sources

Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways [PDF]

, 2020
Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known that extracellular nucleotides regulate bone homeostasis raising an emerging interest in the ...
D’Haese, P C, Neven, E, Opdebeeck, B, Orriss, I, Verhulst, A   +4 more
core   +1 more source

TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate

British Journal of Pharmacology, Volume 182, Issue 6, Page 1324-1340, March 2025.
Background and Purpose Abdominal pain is a leading cause of morbidity for people living with gastrointestinal disease. Whereas the transient receptor potential vanilloid 4 (TRPV4) ion channel has been implicated in the pathogenesis of abdominal pain, the relative paucity of TRPV4 expression in colon‐projecting sensory neurons suggests that non‐neuronal
Michelle Y. Meng, Luke W. Paine, David Sagnat, Ivana Bello, Sophie Oldroyd, Farideh Javid, Matthew T. Harper, James R. F. Hockley, Ewan St. John Smith, Róisín M. Owens, Laurent Alric, Etienne Buscail, Fraser Welsh, Nathalie Vergnolle, David C. Bulmer   +14 more
wiley   +1 more source

P2X and P2Y receptor signaling in red blood cells

Frontiers in Molecular Biosciences, 2015
Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
Ronald eSluyter, Ronald eSluyter, Ronald eSluyter   +2 more
doaj   +1 more source

P2Y1 Receptor as a Catalyst of Brain Neurodegeneration

NeuroSci, 2022
Different brain disorders display distinctive etiologies and pathogenic mechanisms. However, they also share pathogenic events. One event systematically occurring in different brain disorders, both acute and chronic, is the increase of the extracellular ...
Ricardo J. Rodrigues, Ana S. Figueira, Joana M. Marques   +2 more
doaj   +1 more source

Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]

, 2008
Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core  

Action Potential Firing Patterns Regulate Dopamine Release via Voltage‐Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo

Advanced Science, Volume 12, Issue 7, February 17, 2025.
Sun et al. uncover a novel dopamine transmission pathway: the membrane potential or action potential firings not only trigger dopamine release, but also modulate dopamine release by directly targeting voltage‐sensitive D2 receptor via the voltage‐sensing site D131, mediating the facilitation of voltage‐gated calcium channels, thus tuning dopamine ...
Xiaoxuan Sun, Lili Yin, Zhongjun Qiao, Muhammad Younus, Guoqing Chen, Xi Wu, Jie Li, Xinjiang Kang, Huadong Xu, Li Zhou, Yinglin Li, Min Gao, Xingyu Du, Yuqi Hang, Zhaohan Lin, Liyuan Sun, Qinglong Wang, Ruiying Jiao, Lun Wang, Meiqin Hu, Yuan Wang, Rong Huang, Yiman Li, Qihui Wu, Shujiang Shang, Shu Guo, Qian Lei, Haifeng Shu, Lianghong Zheng, Shirong Wang, Feipeng Zhu, Panli Zuo, Bing Liu, Changhe Wang, Quanfeng Zhang, Zhuan Zhou   +35 more
wiley   +1 more source

Who Is Who in Adenosine Transport

Frontiers in Pharmacology, 2018
Extracellular adenosine concentrations are regulated by a panel of membrane transporters which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two gene families encoding Equilibrative and Concentrative Nucleoside ...
Marçal Pastor-Anglada, Marçal Pastor-Anglada, Sandra Pérez-Torras, Sandra Pérez-Torras   +3 more
doaj   +1 more source

A bottom‐up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors

Glia, Volume 73, Issue 2, Page 330-351, February 2025.
Main Points We searched for phagocytosis modulators using two high throughput screenings at Achucarro and Roche. We identified the antipsychotic/antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as inhibitors of microglial phagocytosis.
Noelia Rodriguez‐Iglesias, Iñaki Paris, Jorge Valero, Lorena Cañas‐Zabala, Alejandro Carretero, Klas Hatje, Jitao David Zhang, Christoph Patsch, Markus Britschgi, Simon Gutbier, Amanda Sierra   +10 more
wiley   +1 more source