Results 101 to 110 of about 28,974 (217)
Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function
Frontiers in Immunology, 2020 Intracellular ATP is the universal energy carrier that fuels many cellular processes. However, immune cells can also release a portion of their ATP into the extracellular space.
Carola Ledderose, W. Junger
semanticscholar +1 more source
Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine
Advanced Science, Volume 12, Issue 3, January 20, 2025.Harnessing the robust electromechanical coupling of piezoelectric materials, this review explores their applications in orthopedic medicine, inspired by collagen's natural piezoelectricity in bones. It covers how these materials accelerate osteogenesis, regulate cellular microenvironments through ion channels and signaling pathways, and enhance bone ...
Jingkai Zhang +5 more
wiley +1 more source
Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]
, 1998 Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
Boyer, José L. +13 more
core +3 more sources
The Role of Ion Channels in Pulmonary Hypertension: A Review
Pulmonary Circulation, Volume 15, Issue 1, January 2025.ABSTRACT Pulmonary hypertension (PH) constitutes a critical challenge in cardiopulmonary medicine with a pathogenesis that is multifaceted and intricate. Ion channels, crucial determinants of cellular electrochemical gradient modulation, have emerged as significant participants in the pathophysiological progression of PH.
Han‐Fei Li +11 more
wiley +1 more source
Differences in localization of P2X7 during epithelial wound healing in pre-type II diabetic models [PDF]
, 2017 Corneal injury, accompanied by improper wound repair, is the 4th highest cause of preventable blindness according to the World Health Organization.
Kneer, Krisandra
core
Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta
European Journal of Histochemistry, 2009 Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/ CD39) is the dominant ecto-nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type-2 purinergic (P2) Gprotein coupled receptors (GPCRs).
A Kittel +4 more
doaj +1 more source
Role of inflammasomes and neuroinflammation in epilepsy
Immunological Reviews, Volume 329, Issue 1, January 2025.Summary Epilepsy is a brain disorder characterized by recurrent seizures, which are brief episodes of abnormal electrical activity in the brain and involuntary movement that can lead to physical injury and loss of consciousness. Seizures are canonically accompanied by increased inflammatory cytokine production that promotes neuroinflammation, brain ...
Ava Hollis, John R. Lukens
wiley +1 more source
Short- and long-term (trophic) purinergic signalling [PDF]
, 2016 There is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body, in addition to fast purinergic signalling in neurotransmission ...
Burnstock, G
core +1 more source
Deletion of Cd39/Entpd1 Results in Hepatic Insulin Resistance [PDF]
, 2008 OBJECTIVE—Extracellular nucleotides are important mediators of inflammatory responses and could also impact metabolic homeostasis. Type 2 purinergic (P2) receptors bind extracellular nucleotides and are expressed by major peripheral tissues responsible ...
Bleibel, Wissam +11 more
core +2 more sources
Bio-Protocol, 2019 Extracellular ATP is a potent signaling molecule that stimulates intracellular calcium responses through purinergic (P2) receptors in mammalian cells. While extracellular ATP and intracellular calcium can be measured separately, simultaneous monitoring ...
Nicholas Mikolajewicz, Svetlana Komarova
doaj +1 more source