Results 181 to 190 of about 14,791 (200)

P2 Purinergic Receptors in Tumor Immunity

Cancer Research
Abstract P2 purinergic receptors are activated by extracellular ATP and other nucleotides released during cellular stress, hypoxia, or inflammation, serving as key mediators of intercellular communication. In cancer, they rapidly accumulate in the tumor microenvironment following cell death or metabolic stress.
Xin Wang, Shu-Heng Jiang, Mingyue Ma, Shuqi Cai, Dong Song, Bing Han   +5 more
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RT-PCR study of purinergic P2 receptors in hematopoietic cell lines

Biochemistry (Moscow), 2006
Seven P2X and fifteen P2Y receptors have been identified to date, partly on the basis of amino acid sequence homologies. The expression of all cloned human purinergic P2 receptors was investigated on the messenger RNA level in promonocytic U937 cells, erythroblastic K562 cells, and undifferentiated, dimethyl sulfoxide-differentiated granulocytic, and ...
M K, Bernhard, K, Ulrich
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P2 purinergic receptors signal to glycogen synthase kinase‐3β in astrocytes

Journal of Neuroscience Research, 2006
AbstractGlycogen synthase kinase (GSK)‐3 was identified initially as an enzyme that regulates glycogen synthesis in response to insulin, but more recent studies indicate that it is also involved in numerous cellular processes, including cell survival, cell cycle regulation, proliferation, and differentiation.
Joseph T, Neary, Yuan, Kang
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Ca2+ mobilization in bovine corneal endothelial cells by P2 purinergic receptors

Current Eye Research, 1998
To characterize Ca2+ mobilization by P2 receptors in the bovine corneal endothelial cells (BCEC).Changes in intracellular Ca2+ ([Ca2+]i) were measured by fluorescence imaging of cultured and fresh BCEC cells loaded with the Ca2+-sensitive dye Fura-PE3.
S P, Srinivas, J C, Yeh, A, Ong, J A, Bonanno   +3 more
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Modulation of Cyclooxygenase‐2 and Brain Reactive Astrogliosis by Purinergic P2 Receptors

Annals of the New York Academy of Sciences, 2001
Abstract:Astroglial cells respond to trauma and ischemia with reactive gliosis, a reaction characterized by increased astrocytic proliferation and hypertrophy. Although beneficial to a certain extent, excessive gliosis may be detrimental, contributing to neuronal death in neurodegenerative diseases.
R. Brambilla, M. P. Abbracchio
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P1 and P2 purinergic receptor signal transduction in rat type II pneumocytes

Journal of Applied Physiology, 1989
Extracellular ATP is a potent agonist of surfactant phosphatidylcholine (PC) exocytosis from type II pneumocytes in culture. We studied P1 and P2 receptor signal transduction in type II pneumocytes. The EC50 for ATP on PC exocytosis was 10(-6) M, whereas the EC50 for ADP, AMP, adenosine, and the nonmetabolizable ATP analogue alpha,beta-methylene ATP ...
D, Warburton, S, Buckley, L, Cosico
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Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

American Journal of Physiology-Cell Physiology, 1993
Extracellular ATP, at micromolar concentrations, induces significant functional changes in a wide variety of cells and tissues. ATP can be released from the cytosol of damaged cells or from exocytotic vesicles and/or granules contained in many types of secretory cells.
G R, Dubyak, C, el-Moatassim
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Extracellular ATP stimulates proliferation of cultured mesangial cells via P2-purinergic receptors

American Journal of Physiology-Renal Physiology, 1992
We examined the role of the platelet product ATP in regulating replication and secretory activity of cultured rat mesangial cells (MCs). Extracellular ATP (25-100 microM) significantly increased [3H]thymidine uptake of growth-arrested MCs 2.1-fold; cell counts increased by 35.1%. Addition of ATP to MCs in combination with other platelet products, such
E, Schulze-Lohoff, S, Zanner, A, Ogilvie, R B, Sterzel   +3 more
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Regulation of transcervical permeability by two distinct P2 purinergic receptor mechanisms

American Journal of Physiology-Cell Physiology, 2002
Micromolar concentrations of ATP stimulate biphasic change in transepithelial conductance across CaSki cultures, an acute increase (phase I response) followed by a slower decrease ( phase II response). Phase I and phase II responses involve two distinct calcium-dependent pathways, calcium mobilization and calcium influx.
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Purinergic P2 Receptors in Epilepsy

2023
Jonathon Smith, Tobias Engel
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