Results 61 to 70 of about 14,791 (200)
BMC Immunology, 2006 Background Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic receptors, consisting of P2X and P2Y,
Kim Jun Woo +4 more
doaj +1 more source
Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function
Frontiers in Physiology, 2022 Blood-brain-barrier permeability is regulated by endothelial junctional proteins and is vital in limiting access to and from the blood to the CNS. When stressed, several cells, including endothelial cells, can release nucleotides like ATP and ADP that ...
Somasundaram Raghavan +3 more
doaj +1 more source
Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]
, 2008 Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley +1 more source
The role of purinergic signaling in microglial responses
Stress and Brain, 2021 Microglia, the primary immune cells in the central nervous system (CNS), are key to the maintenance of homeostasis in the brain parenchyma. In the intact brain, microglia continuously survey the microenvironment with ramified processes.
Yaling Hu, Zhihua Gao
doaj +1 more source
Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release [PDF]
, 2017 Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation, the functional effects of this receptor in ...
Arnett, T R +5 more
core +2 more sources
Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu +4 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP).
Shelly C. Y. Lin +3 more
doaj +1 more source
Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]
, 2008 To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L. +7 more
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Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]
, 2000 Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
Burnstock, G +5 more
core +1 more source