Results 71 to 80 of about 13,842 (161)

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential [PDF]

, 2012
P2Y receptors for extracellular nucleotides are coupled to activation of a variety of G proteins and stimulate diverse intracellular signaling pathways that regulate functions of cell types that comprise the central nervous system (CNS).
Erb, Laurie, Seye, Cheik I., Weisman, Gary A., Woods, Lucas T.   +3 more
core   +1 more source

Spatio‐Temporal Diversity of Calcium Activity in Microglia

Glia, Volume 74, Issue 3, March 2026.
Ca2+ activity mostly occurs in microglial processes and stays localized. When it spreads, it often shows a directional bias and is constrained by branch points. Activity strongly relies on P2Y12 receptors and is shaped by neuronal activity. ABSTRACT Microglia, the brain's innate immune cells, possess complex, highly motile branched processes. These act
Hiroshi Horiuchi, Dennis Lawrence Cheung, Junko Ishida, Junichi Nabekura   +3 more
wiley   +1 more source

Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype: Implications for GI Infection, IBD, POI, Neurological, Motility, and GI Disorders [PDF]

, 2016
BACKGROUND: Clinical observations or animal studies implicate enteric glial cells in motility disorders, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal (GI) infections, postoperative ileus, and slow transit constipation ...
Abdel Rasoul, Mahmoud, Arsenescu, Razvan, Christofi, Fievos L., CUOMO, ROSARIO, Fadda, Paolo, Grants, Iveta, Harzman, Alan, Liñán Rico, Andromeda, Needleman, Bradley J, Ochoa Cortes, Fernando, TURCO, FABIO, Whitaker, Emmett   +11 more
core   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Apical membrane P2Y4 purinergic receptor controls K⁺ secretion by strial marginal cell epithelium

Cell Communication and Signaling, 2005
Background It was previously shown that K+ secretion by strial marginal cell epithelium is under the control of G-protein coupled receptors of the P2Y family in the apical membrane.
Scofield Margaret A, Scherer Elias Q, Lee Jun, Liu Jianzhong, Marcus Daniel C, Wangemann Philine   +5 more
doaj   +1 more source

Protective role of P2Y2 receptor against lung infection induced by pneumonia virus of mice. [PDF]

PLoS ONE, 2012
ATP released in the early inflammatory processes acts as a danger signal by binding to purinergic receptors expressed on immune cells. A major contribution of the P2Y(2) receptor of ATP/UTP to dendritic cell function and Th2 lymphocyte recruitment during
Gilles Vanderstocken, Els Van de Paar, Bernard Robaye, Larissa di Pietrantonio, Benjamin Bondue, Jean-Marie Boeynaems, Daniel Desmecht, Didier Communi   +7 more
doaj   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Adenosine Receptor Agonists Exhibit Anti-Platelet Effects and the Potential to Overcome Resistance to P2Y₁₂ Receptor Antagonists

Molecules, 2019
Large inter-individual variation in platelet response to endogenous agonists and pharmacological agents, including resistance to antiplatelet therapy, prompts a search for novel platelet inhibitors and development new antithrombotic strategies.
Nina Wolska, Magdalena Boncler, Dawid Polak, Joanna Wzorek, Tomasz Przygodzki, Magdalena Gapinska, Cezary Watala, Marcin Rozalski   +7 more
doaj   +1 more source

Regional differences in store-operated Ca2+ entry in the epithelium of the intact human lens [PDF]

, 2009
An elevated level of Ca2+ is an important factor in cataract, yet precisely how Ca2+ enters the lens is unknown. Lens epithelial cells contain a range of G-protein–coupled receptors and receptor tyrosine kinases that induce increases in intracellular Ca2+
Duncan, George, Illingworth, Christopher D., Rhodes, Jeremy D., Russell, Sarah L., Wormstone, I. Michael   +4 more
core   +1 more source