Results 21 to 30 of about 57,506 (257)
PLoS ONE, 2011 BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors.
Yuen Fei Wong +8 more
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Potential role of nuclear receptor ligand all-trans retinoic acids in the treatment of fungal keratitis [PDF]
International Journal of Ophthalmology, 2015 Fungal keratitis (FK) is a worldwide visual impairment disease. This infectious fungus initiates the primary innate immune response and, later the adaptive immune response.
Hong-Yan Zhou +5 more
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Translational Oncology, 2021 Despite advances in personalised medicine and the emerging role of immune checkpoints in directing treatment decisions in subsets of lung cancer patients, non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related deaths worldwide.
Lauren MacDonagh +7 more
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Molecular Imaging, 2004 Retinoic acids are natural derivatives of vitamin A, and play important roles in modulating tumor cell growth by regulating differentiation, thus suggesting the potential use of these derivatives in cancer therapy and prevention.
Min Kyung So +8 more
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Frontiers in Oncology, 2022 Acute promyelocytic leukemia (APL) accounts for 10–15% of newly diagnosed acute myeloid leukemias (AML) and is typically caused by the fusion of promyelocytic leukemia with retinoic acid receptor α (RARA) gene.
Luca Guarnera +13 more
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Neofunctionalization in vertebrates: the example of retinoic acid receptors. [PDF]
PLoS Genetics, 2006 Understanding the role of gene duplications in establishing vertebrate innovations is one of the main challenges of Evo-Devo (evolution of development) studies.
Hector Escriva +9 more
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Frontiers in Cellular and Infection Microbiology, 2022 Pattern recognition receptors (PRRs) play critical roles in recognizing pathogen-derived nucleic acids and inducing innate immune responses, such as inflammation and type I interferon production.
Norisuke Kano +3 more
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The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
Nature Communications, 2017 Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and ...
Vikas Chandra +5 more
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Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids. [PDF]
PLoS ONE, 2010 Histone deacetylase (HDAC) inhibitors arrest cancer cell growth and cause apoptosis with low toxicity thereby constituting a promising treatment for cancer.
Shaoteng Han +7 more
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Molecular Metabolism, 2022 Objective: The β-carotene oxygenase 1 (BCO1) is the enzyme responsible for the cleavage of β-carotene to retinal, the first intermediate in vitamin A formation. Preclinical studies suggest that BCO1 expression is required for dietary β-carotene to affect
Johana Coronel +4 more
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