Results 101 to 110 of about 26,499 (240)
ヒトPRE-Bリンパ腫細胞株RC-K8におけるBeraprost(a stable analogue of prostacyclin)によるuPA産生抑制効果 [PDF]
, 1996 Plasminogen activation by urokinase-type plasminogen activator (uPA) is implicated in tumor invasion and metastasis by the breakdown of extracellular matrix.We have recently demonstrated the inhibitory effect of cAMP on uPA gene transcription in RC-K8 ...
Nomura Naoki
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Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones [PDF]
, 2013 Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation,
Ammollo +36 more
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Precision Radiation Oncology, EarlyView.The prognosis of LUAD was significantly influenced by many clinical and protein biomarkers. A risk model was developed to help identify advanced LUAD patients who would benefit from thoracic radiotherapy, and thoracic radiotherapy just significantly improved the survival of low‐risk patients but not that of high‐risk.
Chunliu Meng +7 more
wiley +1 more source
The role of proteases in pathologies of the synovial joint [PDF]
, 2008 Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
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British Journal of Haematology, EarlyView.Bone marrow (BM) involvement in B‐cell non‐Hodgkin lymphoma (B‐NHL) is associated with poor prognosis, as the BM microenvironment provides a protective niche that promotes therapeutic resistance. We developed a simplified, automated and high‐throughput 3D BM co‐culture model that faithfully reproduces key tumour–stroma interactions.
Alex Zadro +12 more
wiley +1 more source
Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells
BMC Cancer, 2011 Background A major problem with the use of current chemotherapy regimens for several cancers, including breast cancer, is development of intrinsic or acquired drug resistance, which results in disease recurrence and metastasis.
Choi Changsun +6 more
doaj +1 more source
Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]
, 2017 A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro +4 more
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Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?
British Journal of Pharmacology, EarlyView.Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi +10 more
wiley +1 more source
Nature CommunicationsCoagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as a zymogen via surface receptors like urokinase-type plasminogen activator receptor (uPAR).
Ahmed Elwakiel +26 more
doaj +1 more source
Tissue plasminogen activator-based clot busting: Controlled delivery approaches. [PDF]
, 2014 Cardiovascular diseases are the leading cause of death worldwide. Thrombosis, the formation of blood clot (thrombus) in the circulatory system obstructing the blood flow, is one of the main causes behind various ischemic arterial syndromes such as ...
El-Sherbiny, IM, Elkholi, IE, Yacoub, MH
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