Results 131 to 140 of about 26,499 (240)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, Volume 16, Issue 2, Page 314-330, February 2026.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model.

PLoS ONE, 2008
Of the estimated 565,650 people in the U.S. who will die of cancer in 2008, almost all will have metastasis. Breast, prostate, kidney, thyroid and lung cancers metastasize to the bone.
Tamara E King, Sangita C Pawar, Lisa Majuta, Isis C Sroka, Danyel Wynn, Manolis C Demetriou, Raymond B Nagle, Frank Porreca, Anne E Cress   +8 more
doaj   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations

American Journal of Biological Anthropology, Volume 189, Issue 2, February 2026.
ABSTRACT Objectives Whereas chronic inflammation is a hallmark of aging in many human populations, inflammaging is reduced in groups characterized by frequent physical activity and diets low in processed foods. Since most biomarkers of inflammation require blood sampling, comparative data from our closest primate relatives have been derived from ...
Megan F. Cole, Melissa Emery Thompson, Nicole Thompson González, Eleanor Paskus, Joshua Rukundo, Rebeca Atencia, Alexandra G. Rosati   +6 more
wiley   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Successful conservative management of an intravesicular haematoma in a cat with prior urethral obstruction

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract An 8‐year‐old male neutered domestic shorthair cat was presented for the management of severe anaemia and post‐urethral obstruction care. A large intravesicular lesion, which was suspected to be a haematoma, was identified via abdominal ultrasound. This was suspected to be secondary to bleeding in the urinary tract.
Alison Robertson, Laura Cole, Karen Humm
wiley   +1 more source

Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors [PDF]

The Journal of cell biology, 1987
Blasi, F., Vassalli, Jean-Dominique, Dano, K.   +2 more
openaire   +3 more sources

Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients [PDF]

, 2017
Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients.
Beex, Louk V. A. M., Bendahl, Pär-Ola, Blankenstein, Marinus A., Borstnar, Simona, Broët, Philippe, Brünner, Nils, Christensen, Ib Jarle, Cufer, Tanja, Daver, Alain, Daxenbichler, Günter, Duffy, Michael J., Duggan, Catherine, Eppenberger, Urs, Eppenberger-Castori, Serenella, Fernö, Mårten, Fiets, W. Edward, Foekens, John A., Harbeck, Nadia, Jänicke, Fritz, Kates, Ronald, Klijn, Jan G. M., Kueng, Willy, Lisboa, Björn W., Look, Maxime P., Magdelenat, Henri, Manders, Peggy, Martin, Pierre-Marie, Meijer-van Gelder, Marion E., O'Higgins, Niall, Peyrat, Jean-Philippe, Quillien, Véronique, Ricolleau, Gabriel, Romain, Sylvie, Schmitt, Manfred, Spyratos, Frédérique, Sweep, C. G. J. Fred, Thomssen, Christoph, Ulm, Kurt, van Putten, Wim L. J., Windbichler, Gudrun   +39 more
core  

Biomarkers in Schizophrenia: Current Approaches and New Developments—A Literature Review

Behavioural Neurology
Schizophrenia (SZ) is categorized as a chronic severe highly heritable brain disease. Symptoms include positive, negative, and cognitive symptoms. Despite numerous theories concerning the etiopathogenesis of SZ, the symptoms, although characteristic in ...
Alicja Sierakowska, Ewa Niewiadomska, Sebastian Łabuda, Anna Bieniasiewicz, Mateusz Roszak, Beata Łabuz-Roszak   +5 more
doaj   +1 more source