Results 21 to 30 of about 26,499 (240)

Expression of urokinase plasminogen activator and the urokinase plasminogen activator receptor in myeloma cells [PDF]

British Journal of Haematology, 2000
Binding of urokinase (uPA) to its receptor (uPAR; CD87) focuses proteolytic activity on the cell surface and this system is of importance in malignant matrix degradation and tumour invasion. By immunocytochemistry and flow cytometry, we found that primary myeloma cells and myeloma cell lines expressed uPA and uPAR.
O, Hjertner, G, Qvigstad, H, Hjorth-Hansen, C, Seidel, J, Woodliff, J, Epstein, A, Waage, A, Sundan, M, Börset   +8 more
openaire   +2 more sources

In vitro identification of novel plasminogen-binding receptors of the pathogen Leptospira interrogans. [PDF]

PLoS ONE, 2010
BACKGROUND: Leptospirosis is a multisystem disease caused by pathogenic strains of the genus Leptospira. We have reported that Leptospira are able to bind plasminogen (PLG), to generate active plasmin in the presence of activator, and to degrade purified
Monica L Vieira, Marina V Atzingen, Tatiane R Oliveira, Rosane Oliveira, Daniel M Andrade, Silvio A Vasconcellos, Ana L T O Nascimento   +6 more
doaj   +1 more source

In Vitro Study of the Fibrinolytic Activity via Single Chain Urokinase-Type Plasminogen Activator and Molecular Docking of FGFC1

Molecules, 2021
Fungi fibrinolytic compound 1 (FGFC1) is a rare marine-derived compound that can enhance fibrinolysis both in vitro and in vivo. The fibrinolytic activity characterization of FGFC1 mediated by plasminogen (Glu-/Lys-) and a single-chain urokinase-type ...
Chunli Gao, Quan Shen, Pengjie Tang, Yuling Cao, Houwen Lin, Bailin Li, Peng Sun, Bin Bao, Wenhui Wu   +8 more
doaj   +1 more source

Function of hepatocyte growth factor in gastric cancer proliferation and invasion [PDF]

Yeungnam University Journal of Medicine, 2020
Cancer incidence has been increasing steadily and is the leading cause of mortality worldwide. Gastric cancer is still most common malignancy in Korea. Cancer initiation and progression are multistep processes involving various growth factors and their ...
Sung Ae Koh, Kyung Hee Lee
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Determining biomarkers for evaluation and diagnosis of hereditary angioedema

Clinical and Translational Allergy, 2022
Rationale Kallikrein‐bradykinin‐forming cascade is known to cause hereditary angioedema (HAE) acute angioedema (AE) attacks. Further research of HAE attacks is needed to explain disease heterogeneity, predict treatment response and identify biomarkers ...
Umesh Singh, Jonathan A. Bernstein
doaj   +1 more source

A study of the interaction between Helicobacter pylori and components of the human fibrinolytic system

Brazilian Journal of Medical and Biological Research, 2000
The interaction of plasminogen, tissue plasminogen activator (t-PA) and urokinase with a clinical strain of Helicobacter pylori was studied. Plasminogen bound to the surface of H. pylori cells in a concentration-dependent manner and could be activated to
A. Yarzábal, L. Avilán, K. Hoelzl, M. de Muñoz, J. Puig, I. Kansau   +5 more
doaj   +1 more source

Soluble urokinase plasminogen activator receptor: a novel biomarker of pediatric community-acquired and hospitalacquired pneumonia

The Turkish Journal of Pediatrics, 2022
Background. Soluble urokinase plasminogen activator receptor (suPAR) is an emerging biomarker in different clinical disorders but data in pediatric pneumonia is scarce.
Muhammad Said El-Mekkawy, Shimaa El-Shafey Soliman, Nagwan Yossery Saleh   +2 more
doaj   +1 more source

The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection [PDF]

, 2016
The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and invades various cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase.
Almeida, Andrade, Antunez, Aune, Avilan, Bern, Cardillo, Carlier, Carnaud, Cesari, Collins, Culbertson, Dowling, Duthie, Duthie, Duthie, Filtjens, Fraser, Frosch, Gritz, Hanke, Keating, Lieke, Lieke, Mekkawy, Meyer Zum Buschenfelde, Mondino, Nagata, Nogueira, Pettengill, Pinazo, Rassi, Robertson, Rottenberg, Santana, Sardinha, Stevenaert, Taveirne, Torrico, Truyens, Truyens, Truyens, Une, Van Beneden, Van Beneden, Van Den Broeck, Van Den Broeck, Vassalli, Wen   +48 more
core   +2 more sources

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]

, 2009
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher, Birchmeier, Bugge, Chirgadze, Collen, Deyi Qiu, Ellis, Ellis, Gherardi, Harris, Herter, Høyer-Hansen, Itoh, Jennifer L. Harris, Juliano Alves, Jun Li, Kate A. Owen, Ke, Kemp, Kilpatrick, Kirchhofer, Kirchhofer, Lamszus, Lee, Lynette M. Kilpatrick, Mangel, Marcotte, Mars, Mars, Matsuoka, Miyazawa, Mizuno, Mohammed, Naldini, Naldini, Qiu, Rahman, Riddick, Schmidt, Shanmukhappa, Shimizu, Shimomura, Steinmetzer, Stephens, Takeuchi, Uehara, Vincent Ellis, You   +47 more
core   +3 more sources