Results 51 to 60 of about 12,163 (157)

Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis [PDF]

Scientific Reports, 2017
AbstractIn order to develop an improved BCG vaccine against tuberculosis we have taken advantage of the adjuvant properties of a non-toxic derivative of Escherichia coli heat labile enterotoxin (LT), LTAK63. We have constructed rBCG strains expressing LTAK63 at different expression levels.
Nascimento, Ivan, Rodriguez, Dunia, Santos, C.C., Amaral, E.P., Rofatto, H.K., Junqueira-Kipnis, A.P., Gonçalves, E.D.C., d'Império-Lima, M.R., Hirata, M.H., Silva, C.L., Winter, Nathalie, Gicquel, Brigitte, Mills, K.H.G., Pizza, Mariagrazia, Rappuoli, Rino, Leite, L.C.C.   +15 more
openaire   +7 more sources

Thirty years of recombinant BCG: new trends for a centenary vaccine

Expert Review of Vaccines, 2021
Introduction: Global perception of the potential for Bacille Calmette-Guérin (BCG), and consequently recombinant BCG (rBCG), in a variety of prophylactic and therapeutic applications has been increasing. A century of information on BCG, and three decades of experience with rBCG, has generated solid knowledge in this field. Area covered: Here, we review
Lazaro M Marques-Neto, Zuzanna Piwowarska, Alex I. Kanno, Luana Moraes, Monalisa M Trentini, Dunia Rodriguez, Jose L. S. C. Silva, Luciana C. C. Leite   +7 more
openaire   +2 more sources

The tuberculosis vaccine candidate Bacillus Calmette-Guérin ΔureC::hly coexpressing human interleukin-7 or -18 enhances antigen-specific T cell responses in mice. [PDF]

PLoS ONE, 2013
Bacillus Calmette-Guérin (BCG), the only approved tuberculosis vaccine, provides only limited protection. Previously, we generated a recombinant derivative (BCG ΔureC::hly), which secretes the pore-forming toxin listeriolysin O (LLO) of Listeria ...
Martin Rao, Alexis Vogelzang, Peggy Kaiser, Stefanie Schuerer, Stefan H E Kaufmann, Martin Gengenbacher   +5 more
doaj   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, Volume 299, Issue 3, Page 328-348, March 2026.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

Comparison of two BCG adjuvants in enhancing the immunogenicity of a DNA vaccine encoding the Toxoplasma gondii ROP2 gene in BALB/c mice

The Microbe
The lack of a definitive treatment against toxoplasmosis and its high prevalence encouraged us to seek ways to expand DNA vaccines. The rhoptry protein 2 (ROP2) of Toxoplasma gondii is one of the most important antigens expressed in all three stages of ...
Hamed Yousefi, Fatemeh Ghaffarifar, Masoud Foroutan, Hélder Cortes, Kamy Hosseinian Khosroshahi   +4 more
doaj   +1 more source

rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector. [PDF]

PLoS ONE, 2008
BACKGROUND: BCG vaccination, combined with adenoviral-delivered boosts, represents a reasonable strategy to augment, broaden and prolong immune protection against tuberculosis (TB).
Isabelle Magalhaes, Donata R Sizemore, Raija K Ahmed, Stefanie Mueller, Lena Wehlin, Charles Scanga, Frank Weichold, Giulia Schirru, Maria Grazia Pau, Jaap Goudsmit, Sharon Kühlmann-Berenzon, Mats Spångberg, Jan Andersson, Hans Gaines, Rigmor Thorstensson, Yasir A W Skeiky, Jerry Sadoff, Markus Maeurer   +17 more
doaj   +1 more source

Engineering Immortalized Bovine Granulosa Cells Using a Triple‐Gene Approach: Mutant CDK4, Cyclin D1, and TERT

Cell Biology International, Volume 50, Issue 2, February 2026.
ABSTRACT Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction
Lanlan Bai, Minami Takahashi, Jin Kobayashi, Takahiro Eitsuka, Himari Matsusaka, Taku Ozaki, Eriko Sugano, Hiroshi Tomita, Yuan Xu, Kazuhiro Kawamura, Kiyotaka Nakagawa, Tohru Kiyono, Tomokazu Fukuda   +12 more
wiley   +1 more source

Bacille Calmette–Guérin (BCG)-associated inflammation and fibrosis: modulation by recombinant BCG expressing interferon-gamma (IFN-γ) [PDF]

Clinical and Experimental Immunology, 2000
SUMMARYImmunization with existing BCG vaccines has failed to confer consistent protection against tuberculosis. One of the ways to improve the efficacy of BCG is by enhancing its ability to induce a type-1 T cell response. However, this approach carries the risk that enhanced immunoreactivity may exacerbate tissue pathology associated with vaccination.
A, Wangoo, I N, Brown, B G, Marshall, H T, Cook, D B, Young, R J, Shaw   +5 more
openaire   +2 more sources

BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and Andes orthohantavirus

Vaccines, 2022
Background:Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine mainly administered to newborns and used for over 100 years to prevent the disease caused by Mycobacterium tuberculosis (M. tb).
Jorge A. Soto, Fabián E. Díaz, Angello Retamal-Díaz, Nicolás M. S. Gálvez, Felipe Melo-González, Alejandro Piña-Iturbe, Mario A. Ramírez, Karen Bohmwald, Pablo A. González, Susan M. Bueno, Alexis M. Kalergis   +10 more
doaj   +1 more source

Loss of METTL3 m6A methyltransferase results in short‐term progression and poor treatment outcome of bladder cancer patients

International Journal of Cancer, Volume 158, Issue 3, Page 763-774, 1 February 2026.
What's new? Bladder cancer exhibits a highly heterogeneous molecular landscape and treatment response. The dysregulation of RNA modifications such as m6A has been involved in cancer initiation and progression. This study comprehensively analyzed the expression of the main catalytic component of the m6A methylation machinery in bladder tumors across one
Katerina‐Marina Pilala, Stella Koroneou, Maria‐Alexandra Papadimitriou, Konstantina Panoutsopoulou, Konstantinos Soureas, Georgios‐Christos Giagkos, Panagiotis Levis, Dimitrios Linardoutsos, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas   +10 more
wiley   +1 more source