Results 181 to 190 of about 2,311,393 (299)

Reference gene variability across age and sex in 5XFAD mice highlights normalization challenges in Alzheimer's models. [PDF]

Sci Rep
Daini E, Antonioni K, Piemontese M, Bodria M, Zoli M, Vilella A.   +5 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Reference Gene Validation for Quantitative PCR Analysis in 2D and 3D AML12 Hepatocyte Models. [PDF]

Biomedicines
Ivanova Z, Petrova V, Todorova B, Penev T, Grigorova N.   +4 more
europepmc   +1 more source

Evaluation of candidate reference genes for gene expression research in Vespula vulgaris

Frontiers in Insect Science
IntroductionVespula vulgaris is an invasive wasp that causes considerable detriment to native birds and invertebrates in New Zealand. Reducing at least 80% of invasive wasp densities is necessary to manage the problems this species presents to its invaded range. To explore the function of target genes for the genetic management of V.
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Influence of Reference Gene Selection on miRNA Quantification by RT-qPCR in Human Placental Samples. [PDF]

Br J Biomed Sci
Sekovanić A, Orct T, Dorotić A, Pašalić D, Kljaković-Gašpić Z, Stasenko S, Mioč T, Piasek M, Jurasović J.   +8 more
europepmc   +1 more source

Beyond the reference: gene expression variation and transcriptional response to RNA interference in Caenorhabditis elegans. [PDF]

G3 (Bethesda), 2023
Bell AD, Chou HT, Valencia F, Paaby AB.
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

TUG1: a potential endogenous reference gene for long noncoding RNA quantification in blood-based studies. [PDF]

Biomark Res
Rodríguez-Muñoz C, Vila A, Santisteve S, Sánchez-Cucó A, Benítez ID, García-Hidalgo MC, Molinero M, Perez-Pons M, Moncusí-Moix A, Barbé F, González J, de Gonzalo-Calvo D.   +11 more
europepmc   +1 more source

Real-Time Quantitative PCR: Primer Design, Reference Gene Selection, Calculations and Statistics. [PDF]

Metabolites, 2023
Chen Z, Halford NG, Liu C.
europepmc   +1 more source