Results 211 to 220 of about 7,761,125 (307)

TUG1: a potential endogenous reference gene for long noncoding RNA quantification in blood-based studies. [PDF]

Biomark Res
Rodríguez-Muñoz C, Vila A, Santisteve S, Sánchez-Cucó A, Benítez ID, García-Hidalgo MC, Molinero M, Perez-Pons M, Moncusí-Moix A, Barbé F, González J, de Gonzalo-Calvo D.   +11 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Reference Gene Selection for Quantitative Gene Expression Analysis in <i>Argynnis hyperbius</i>. [PDF]

Insects
Xin HJ, Liu CY, Yan F, Wang LD, Zhang HH, Shen CH, Zhai Q.   +6 more
europepmc   +1 more source

Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria. [PDF]

Sci Rep, 2023
Browne DJ, Kelly AM, Brady J, Proietti C, Sarathkumara YD, Pattinson DJ, Doolan DL.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Multiplexed Digital PCR Reference Gene Measurement for Genomic and Cell-Free DNA Analysis. [PDF]

Cells
Yener D, Busby EJ, Vandesompele J, Wils G, Richman SD, Wood HM, Huggett JF, Foy CA, Devonshire AS.   +8 more
europepmc   +1 more source

YWHAZ and TBP are potential reference gene candidates for qPCR analysis of response to radiation therapy in colorectal cancer. [PDF]

Sci Rep, 2023
Kim S, Park JY, Lee HW, Bae SU, Kim KE, Byun SJ, Seo I.   +6 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Stabilizing the Baseline: Reference Gene Evaluation in Three Invasive <i>Reynoutria</i> Species. [PDF]

Int J Mol Sci
Stafiniak M, Makowski W, Matkowski A, Bielecka M.   +3 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source