Results 91 to 100 of about 411,459 (300)

Unraveling the Complex Interplay of Fis and IHF Through Synthetic Promoter Engineering

Frontiers in Bioengineering and Biotechnology, 2020
Bacterial promoters are usually formed by multiple cis-regulatory elements recognized by a plethora of transcriptional factors (TFs). From those, global regulators are key elements since these TFs are responsible for the regulation of hundreds of genes ...
Lummy Maria Oliveira Monteiro, Ananda Sanches-Medeiros, Cauã Antunes Westmann, Rafael Silva-Rocha   +3 more
doaj   +1 more source

CellWalker integrates single-cell and bulk data to resolve regulatory elements across cell types in complex tissues

Genome Biology, 2021
Single-cell and bulk genomics assays have complementary strengths and weaknesses, and alone neither strategy can fully capture regulatory elements across the diversity of cells in complex tissues.
Pawel F. Przytycki, Katherine S. Pollard
doaj   +1 more source

Using Boolean Networks to Model Post-transcriptional Regulation in Gene Regulatory Networks [PDF]

, 2012
In Gene Regulatory Networks research there is a considerable lack of tech- niques and tools to understand these networks from a System Biology point of view. The typical biological approach is to reconstruct a particular network from expression patterns,
Benso, Alfredo, Di Carlo, Stefano, Politano, Gianfranco Michele Maria, Savino, Alessandro, Ur Rehman, Hafeez   +4 more
core  

Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice [PDF]

Molecular Brain, 2014
Higher brain function is supported by the precise temporal and spatial regulation of thousands of genes. The mechanisms that underlie transcriptional regulation in the brain, however, remain unclear. The Ntng1 and Ntng2 genes, encoding axonal membrane adhesion proteins netrin-G1 and netrin-G2, respectively, are paralogs that have evolved in vertebrates
Yaguchi, Kunio, Nishimura-Akiyoshi, Sachiko, Kuroki, Satoshi, Onodera, Takashi, Itohara, Shigeyoshi   +4 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Mapping Regulatory Determinants in Plants

Frontiers in Genetics, 2020
The domestication and improvement of many plant species have frequently involved modulation of transcriptional outputs and continue to offer much promise for targeted trait engineering.
Mary Galli, Fan Feng, Andrea Gallavotti, Andrea Gallavotti   +3 more
doaj   +1 more source

Identification of novel post-transcriptional features in olfactory receptor family mRNAs. [PDF]

, 2015
Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance in olfaction, how most Olfr mRNAs are regulated remains unexplored.
Espinoza, Josh L, Ramaiah, Madhuvanthi, Shum, Eleen Y, Wilkinson, Miles F   +3 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Application of regulatory sequence analysis and metabolic network analysis to the interpretation of gene expression data [PDF]

, 2000
We present two complementary approaches for the interpretation of clusters of co-regulated genes, such as those obtained from DNA chips and related methods.
A. Brazma, A.J. Enright, D. Gilbert, D. Thomas, E. Wingender, E.M. Marcotte, E.M. Marcotte, G. Reinert, H. Salgado, J. Helden van, J. Helden van, J. Helden van, J. Helden van, J. Helden van, J.H. Graber, J.L. DeRisi, M. Kanehisa, M. Pellegrini, M.B. Eisen, M.B. Eisen, P. Tamayo, P.D. Karp, P.O. Brown, P.T. Spellman   +23 more
core   +4 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source