Results 81 to 90 of about 411,459 (300)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Microbiology SpectrumMethanotrophic bacteria show significant promise for methane bioconversion. Despite their ecological and biotechnological importance, the understanding of their transcriptional regulation and genetic regulatory elements remains limited.
Jiyun Bae +4 more
doaj +1 more source
The Distinctive Regulation of Cyanobacterial Glutamine Synthetase [PDF]
, 2018 Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria,
Bolay, Paul +3 more
core +1 more source
Directionality of transcriptional regulatory elements
Abstract Divergent transcription is a critical marker of active transcriptional regulatory elements (TREs), including enhancers and promoters, in mammals. However, distal elements with unidirectional transcriptional patterns are often overlooked, leaving their identity and function poorly understood.
You Chen +8 more
openaire +1 more source
A transcriptional regulatory element critical for CHRNB4 promoter activity in vivo [PDF]
Neuroscience, 2010 Genome-wide association studies have underscored the importance of the clustered neuronal nicotinic acetylcholine receptor (nAChR) subunit genes with respect to nicotine dependence as well as lung cancer susceptibility. CHRNB4, which encodes the nAChR β4 subunit, plays a major role in the molecular mechanisms that govern nicotine withdrawal.
Scofield, Michael D. +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex
Cell Reports, 2019 Summary: Changes in transcriptional regulation through cis-regulatory elements are thought to drive brain evolution. However, how this impacts the identity of primate cortical neurons is still unresolved.
Yoko Arai +16 more
doaj +1 more source
Circadian rhythms and post-transcriptional regulation in higher plants [PDF]
, 2015 The circadian clock of plants allows them to cope with daily changes in their environment. This is accomplished by the rhythmic regulation of gene expression, in a process that involves many regulatory steps.
Romanowski, Andrés +1 more
core +3 more sources
H3K4me3 amplifies transcription at intergenic active regulatory elements
Genes & DevelopmentMammalian genomes undergo pervasive transcription in both genic and intergenic regions. Trimethylation of histone H3 lysine 4 (H3K4me3) is a deeply conserved and functionally important histone modification enriched at transcriptionally active promoters, where it facilitates RNA polymerase activity.
Haoming Yu +4 more
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source