Genome-wide identification of regulatory elements and reconstruction of gene regulatory networks of the green alga Chlamydomonas reinhardtii under carbon deprivation. [PDF]
PLoS ONE, 2013 The unicellular green alga Chlamydomonas reinhardtii is a long-established model organism for studies on photosynthesis and carbon metabolism-related physiology.
Flavia Vischi Winck +8 more
doaj +1 more source
Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions. [PDF]
, 2015 BackgroundCTCF and BORIS (CTCFL), two paralogous mammalian proteins sharing nearly identical DNA binding domains, are thought to function in a mutually exclusive manner in DNA binding and transcriptional regulation.ResultsHere we show that these two ...
Boukaba, Abdelhalim +15 more
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Regulatory Elements Governing Transcription in Specialized Myofiber Subtypes [PDF]
Journal of Biological Chemistry, 2001 Skeletal myofibers of vertebrates acquire specialized metabolic and physiological properties as a consequence of developmental cues in the embryo and different patterns of contractile activity in the adult. The myoglobin gene is regulated stringently in muscle fibers, such that high myoglobin expression is observed in mitochondria-rich, oxidative ...
Yan, Zhen +4 more
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Computational analysis of transcriptional regulatory elements: a field in flux [PDF]
Bioinformatics, 1996 Sequence analytic methods have played a role in the understanding of transcriptional regulation for many years (for example, an alignment of E. coli promoter regions showing conserved upstream regions was reported by Pribnow et al. in 1975). In recent years there has been a tremendous increase in experimental work aimed at understanding the fundamental
Philipp Bucher +2 more
openaire +2 more sources
BMC Bioinformatics, 2022 Background Cell and circadian cycles control a large fraction of cell and organismal physiology by regulating large periodic transcriptional programs that encompass anywhere from 15 to 80% of the genome despite performing distinct functions. In each case,
Francis C. Motta +4 more
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Noise processing by microRNA-mediated circuits: The Incoherent Feed-Forward Loop, revisited [PDF]
, 2016 The intrinsic stochasticity of gene expression is usually mitigated in higher eukaryotes by post-transcriptional regulation channels that stabilise the output layer, most notably protein levels. The discovery of small non-coding RNAs (miRNAs) in specific
De Martino, Andrea +3 more
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Decoding transcription and microRNA-mediated translation control in Drosophila development [PDF]
, 2010 The spatio-temporal regulation of gene expression lies at the heart of animal development. In this article we present an overview of our recent work to apply systems biological approaches to the study of transcription and microRNA-mediated translation ...
Gaul, Ulrike
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Intracompartmental and Intercompartmental Transcriptional Networks Coordinate the Expression of Genes for Organellar Functions [PDF]
, 2011 Genes for mitochondrial and chloroplast proteins are distributed between the nuclear and organellar genomes. Organelle biogenesis and metabolism, therefore, require appropriate coordination of gene expression in the different compartments to ensure ...
Haberer, Georg +4 more
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Extinction of gene expression in somatic cell hybrids. a reflection of important regulatory mechanisms? [PDF]
, 1993 Extinction in somatic cell hybrids is a multifactorial process that leads to loss of cell-type-specific gene expression. The underlying mechanisms are thought to mirror, at least in part, the repertoire of regulatory mechanisms controlling mammalian cell
Boshart, Michael +2 more
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Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. [PDF]
, 2019 Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Amaral, Maria Luisa +21 more
core +2 more sources