An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells [PDF]
, 2015 Funding: This work was supported by the Chief Scientist’s Office (CSO) of the Scottish Government (http://www.cso.scot.nhs.uk/): CWH (CZB-4-477) and IH (ETM/382).Peer reviewedPublisher ...
Hay, Colin W +3 more
core +6 more sources
SMuRF: a novel tool to identify regulatory elements enriched for somatic point mutations
BMC Bioinformatics, 2018 Background Single Nucleotide Variants (SNVs), including somatic point mutations and Single Nucleotide Polymorphisms (SNPs), in noncoding cis-regulatory elements (CREs) can affect gene regulation and lead to disease development.
Paul Guilhamon, Mathieu Lupien
doaj +1 more source
The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer. [PDF]
, 2015 While carcinoma of the prostate is the second most common cause of cancer death in the US, current methods and markers used to predict prostate cancer (PCa) outcome are inadequate.
Benner, Christopher +2 more
core +2 more sources
REDfly: the transcriptional regulatory element database for Drosophila
Nucleic Acids Research, 2018 The REDfly database provides a comprehensive curation of experimentally-validated Drosophila transcriptional cis-regulatory elements and includes information on DNA sequence, experimental evidence, patterns of regulated gene expression, and more. Now in its thirteenth year, REDfly has grown to over 23 000 records of tested reporter gene constructs and ...
John Rivera +3 more
openaire +2 more sources
Identification of germline transcriptional regulatory elements in Aedes aegypti [PDF]
Scientific Reports, 2014 The mosquito Aedes aegypti is the principal vector for the yellow fever and dengue viruses, and is also responsible for recent outbreaks of the alphavirus chikungunya. Vector control strategies utilizing engineered gene drive systems are being developed as a means of replacing wild, pathogen transmitting mosquitoes with individuals refractory to ...
Akbari, Omar S +4 more
openaire +5 more sources
Super-enhancers and novel therapeutic targets in colorectal cancer
Cell Death and Disease, 2022 Transcription factors, cofactors, chromatin regulators, and transcription apparatuses interact with transcriptional regulatory elements, including promoters, enhancers, and super-enhancers (SEs), to coordinately regulate the transcription of target genes
Qian Liu +4 more
doaj +1 more source
High-throughput discovery of post-transcriptional cis-regulatory elements [PDF]
, 2016 Validation of 8mers found in the main screen.
Andrew Grimson +2 more
core +12 more sources
Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells
eLife, 2017 Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters.
Paula Freire-Pritchett +11 more
doaj +1 more source
Molecular Oncology, 2023 Mortality from vmelanoma is associated with metastatic disease, but the mechanisms leading to spreading of the cancer cells remain obscure. Spatial profiling revealed that melanoma is characterized by a high degree of heterogeneity, which is established ...
Veronica Manicardi +10 more
doaj +1 more source
Transcription regulatory elements are punctuation marks for DNA replication [PDF]
Proceedings of the National Academy of Sciences, 2006 Collisions between DNA replication and transcription significantly affect genome organization, regulation, and stability. Previous studies have described collisions between replication forks and elongating RNA polymerases. Although replication collisions with the transcription-initiation or -termination complexes are potentially even more ...
Mirkin EV +3 more
openaire +3 more sources