Results 11 to 20 of about 411,459 (300)
Transcriptional regulatory elements in fungal secondary metabolism [PDF]
The Journal of Microbiology, 2011 Filamentous fungi produce a variety of secondary metabolites of diverse beneficial and detrimental activities to humankind. The genes required for a given secondary metabolite are typically arranged in a gene cluster. There is considerable evidence that secondary metabolite gene regulation is, in part, by transcriptional control through hierarchical ...
Wenbing, Yin, Nancy P, Keller
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Massively parallel characterization of transcriptional regulatory elements [PDF]
NatureAbstract The human genome contains millions of candidate cis -regulatory elements (cCREs) with cell-type-specific activities that shape both health and many disease states 1 . However, we lack a functional understanding of the sequence
Vikram Agarwal +16 more
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Role of Genetic Variation in Transcriptional Regulatory Elements in Heart Rhythm
Cells, 2023 Genetic predisposition to cardiac arrhythmias has been a field of intense investigation. Research initially focused on rare hereditary arrhythmias, but over the last two decades, the role of genetic variation (single nucleotide polymorphisms) in heart ...
Timo Jonker +3 more
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Nature Communications, 2022 How gene regulatory elements regulate gene expression during cellular differentiation remains largely unknown. Here the authors use perturbation-based massively parallel reporter assays at early time points of neural differentiation to systematically ...
Anat Kreimer +6 more
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Systematic discovery of structural elements governing stability of mammalian messenger RNAs. [PDF]
, 2012 Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour.
Cristea, Ileana M +7 more
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Frontiers in Bioengineering and Biotechnology, 2022 Bacteria belonging to Streptomyces have the ability to produce a wide range of secondary metabolites through a shift from primary to secondary metabolism regulated by complex networks activated after vegetative growth terminates.
Soonkyu Hwang +22 more
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cis-regulatory circuits regulating NEK6 kinase overexpression in transformed B cells Are super-enhancer independent [PDF]
, 2017 Alterations in distal regulatory elements that control gene expression underlie many diseases, including cancer. Epigenomic analyses of normal and diseased cells have produced correlative predictions for connections between dysregulated enhancers and ...
Huang, Yue +6 more
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Regulation of IFNβ expression: focusing on the role of its promoter and transcription regulators
Frontiers in Microbiology, 2023 IFNβ is a single-copy gene without an intron. Under normal circumstances, it shows low or no expression in cells. It is upregulated only when the body needs it or is stimulated.
Jiqiang Fan +6 more
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Identification of novel regulatory modules in dicotyledonous plants using expression data and comparative genomics [PDF]
, 2006 Background: Transcriptional regulation plays an important role in the control of many biological processes. Transcription factor binding sites (TFBSs) are the functional elements that determine transcriptional activity and are organized into separable ...
Vandepoele, Klaas +2 more
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CompMoby: Comparative MobyDick for detection of cis-regulatory motifs
BMC Bioinformatics, 2008 Background The regulation of gene expression is complex and occurs at many levels, including transcriptional and post-transcriptional, in metazoans. Transcriptional regulation is mainly determined by sequence elements within the promoter regions of genes
Ramalho-Santos Miguel +6 more
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