Results 31 to 40 of about 9,939 (212)

Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams

PLoS ONE, 2022
In this study, we report our experience in commissioning a commercial treatment planning system (TPS) for fast-raster scanning of carbon-ion beams. This TPS uses an analytical dose calculation algorithm, a pencil-beam model with a triple Gaussian form ...
Masashi Yagi, Toshiro Tsubouchi, Noriaki Hamatani, Masaaki Takashina, Hiroyasu Maruo, Shinichiro Fujitaka, Hideaki Nihongi, Kazuhiko Ogawa, Tatsuaki Kanai   +8 more
doaj   +2 more sources

Limitations in Predicting the Space Radiation Health Risk for Exploration Astronauts [PDF]

, 2018
Despite years of research, understanding of the space radiation environment and the risk it poses to long-duration astronauts remains limited. There is a disparity between research results and observed empirical effects seen in human astronaut crews ...
Auñón-Chancellor, Serena M., Blue, Rebecca S., Cengel, Keith A., Chancellor, Jeffery C., Katzgraber, Helmut G., Kennedy, Ann R., Rubins, Kathleen H.   +6 more
core   +4 more sources

Characterizing Radiation Effectiveness in Ion-Beam Therapy Part II: Microdosimetric Detectors

Frontiers in Physics, 2020
The specific advantages of ion beams for application in tumor therapy are attributed to their different macroscopic and microscopic energy deposition pattern as compared to conventional photon radiation.
Paolo Colautti, Giulio Magrin, Hugo Palmans, Hugo Palmans, Miguel A. Cortés-Giraldo, Valeria Conte   +5 more
doaj   +1 more source

Radiobiological effects and proton RBE determined by wildtype zebrafish embryos. [PDF]

PLoS ONE, 2018
The increasing use of proton radiotherapy during the last decade and the rising number of long-term survivors has given rise to a vital discussion on potential effects on normal tissue.
Emília Rita Szabó, Michael Brand, Stefan Hans, Katalin Hideghéty, Leonhard Karsch, Elisabeth Lessmann, Jörg Pawelke, Michael Schürer, Elke Beyreuther   +8 more
doaj   +1 more source

Mixed- and multi-relative biological effectiveness model simultaneous optimization in carbon ion radiotherapy: A proof-of-concept

Physics and Imaging in Radiation Oncology
Background and purpose: In carbon ion radiotherapy (CIRT), different relative biological effectiveness (RBE) models have been used for calculating RBE-weighted dose (DRBE).
Aaron Paul Osburg, Peter Lysakovski, Giuseppe Magro, Semi Harrabi, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Thomas Tessonnier, Andrea Mairani   +8 more
doaj   +1 more source

Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review

Cancer Medicine, 2023
Background Carbon ion radiotherapy (CIRT) has been applied in cancer treatment for over 25 years. However, guidelines for dose–volume constraints have not been established yet.
Maria Varnava, Atsushi Musha, Mutsumi Tashiro, Nobuteru Kubo, Naoko Okano, Hidemasa Kawamura, Tatsuya Ohno   +6 more
doaj   +1 more source

Clonogenic Survival RBE Calculations in Carbon Ion Therapy: The Importance of the Absolute Values of α and β in the Photon Dose-Response Curve and a Strategy to Mitigate Their Anticorrelation

Quantum Beam Science, 2023
The computation of the relative biological effectiveness (RBE) is a fundamental step in the planning of cancer radiotherapy treatments with accelerated ions.
Alessio Parisi, Chris J. Beltran, Keith M. Furutani   +2 more
doaj   +1 more source

Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy

Advanced Functional Materials, EarlyView.
This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez, Jose I. Garcia‐Peiro, Jose L. Hueso, Eduardo Caleiras, Laura Notario, Felipe Hornos, Pilar Martin‐Duque, Antonio De la Vieja, Jesus Santamaria   +8 more
wiley   +1 more source

Physical characteristics at the turnover-points of relative biological effect (RBE) with linear energy transfer (LET) [PDF]

Physics in Medicine & Biology, 2019
This paper considers the kinematic physical characteristics of ionic beams for maximum relative bio-effectiveness (RBE). RBE studies, based on heterogenous cell survival studies at different laboratories and linear energy transfer (LET) conditions for proton, helium, carbon, neon and argon ions, have been further analysed to determine the LETU values ...
Jones, B, Hill, MA
openaire   +3 more sources

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source