METHODS OF ASSESSMENT OF THE RELATIVE BIOLOGICAL EFFECTIVENESS OF NEUTRONS IN NEUTRON THERAPY
Сибирский онкологический журнал, 2017 The relative biological effectiveness (RBE) of fast neutrons is an important factor influencing the quality of neutron therapy therefore, the assessment of RBE is of great importance.
V. A. Lisin
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Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert proton dose into an equivalent photon dose.
Armin Lühr +10 more
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Deviations from the inverse relationship between tumor and normal tissue dose and RBE in fast neutron data are compatible with the presence of hypoxia, with possible applications to hypo-fractionated proton therapy [PDF]
Frontiers in OncologyAim of studyFast neutron data from Hammersmith (UK) showed that the inverse relationship between dose and RBE (Relative Biological Effectiveness) is not maintained in many in vivo situations, originally attributed to hypoxic effects.
Bleddyn Jones, Bleddyn Jones
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Variable relative biological effectiveness (RBE) in proton therapy of gliomas [PDF]
, 2022 Derzeit gibt es eine intensive Debatte über die Notwendigkeit, Variationen der relativen biologischen Wirksamkeit (RBE) in der Protonentherapie zu berücksichtigen.
Eulitz, Jan
core +3 more sources
The Organ Sparing Potential of Different Biological Optimization Strategies in Proton Therapy
Advances in Radiation Oncology, 2021 Purpose: Variable relative biological effectiveness (RBE) models allow for differences in linear energy transfer (LET), physical dose, and tissue type to be accounted for when quantifying and optimizing the biological damage of protons.
Helge Henjum, MSc +7 more
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Vision and implementation for the first U.S. carbon ion therapy center part I: Clinical rationale and the need for CIRT in the United States. [PDF]
J Appl Clin Med PhysAbstract Carbon ion radiotherapy (CIRT) has evolved into an established clinical modality over the past three decades. Owing to its unique physical and biological characteristics, CIRT has demonstrated favorable outcomes for selected malignancies characterized by radioresistance, proximity to critical organs, locally advanced disease requiring safe ...
Liang X, Beltran CJ.
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A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data. [PDF]
Phys Med Biol, 2015 McNamara AL, Schuemann J, Paganetti H.
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Impact of robust optimization and beam configuration on the distribution stability of LET under delivery uncertainties in carbon-ion therapy. [PDF]
J Appl Clin Med PhysAbstract Background Carbon‐ion radiotherapy exploits high linear energy transfer (LET) to enhance biological effectiveness, and low dose‐averaged LET (LETd) within the target volume is associated with local recurrence in pancreatic cancer. Although robust optimization is widely used to improve dose robustness against delivery uncertainties, systematic ...
Phongprapun W, Tashiro M.
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Dynamic Proton arc therapy for paediatric parameningeal rhabdomyosarcoma. [PDF]
J Appl Clin Med PhysAbstract Background Parameningeal rhabdomyosarcomas (PM‐RMS) are pediatric tumors with a high risk of local failure and severe toxicity. Intensity modulated proton therapy (IMPT) offers improved healthy tissue sparing compared to conventional photon‐based radiotherapy, and proton arc therapy (PAT) might offer further improvement in healthy tissue ...
Handeland AH +6 more
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Dynamic control of carbon-ion radiation dose distribution amid respiratory motion challenges: A review of prediction research using geant4 and deep learning physics-constrained models. [PDF]
J Appl Clin Med PhysAbstract Background Carbon ion radiotherapy (CIRT) offers superior dose conformity and biological effectiveness; however, its precision is highly sensitive to respiratory motion, leading to dose uncertainty and interplay effects that compromise treatment accuracy.
Ding J, Li P, Yeong CH.
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