Biophysical modeling and experimental validation of relative biological effectiveness (RBE) for 4He ion beam therapy [PDF]
Radiation Oncology, 2019 Background Helium (4He) ion beam therapy provides favorable biophysical characteristics compared to currently administered particle therapies, i.e., reduced lateral scattering and enhanced biological damage to deep-seated tumors like heavier ions, while ...
Stewart Mein +12 more
doaj +7 more sources
Relative Biological Effectiveness (RBE) of 131I Radiation Relative to 60Co Gamma Rays [PDF]
Cell Journal, 2013 Objective: To assess relative biological effectiveness (RBE) of 131I radiation relative to 60Co gamma rays in glioblastoma spheroid cells.Materials and Methods: In this experimental study, glioblastoma spheroid cells were exposed to 131I radiation and ...
Seyed Rabie Mahdavi +2 more
doaj +3 more sources
Applied SciencesA constant proton relative biological effectiveness (RBE) of 1.1 for tumor control is currently used in proton therapy treatment planning. However, in vitro, in vivo and clinical experiences indicate that proton RBE varies with kinetic energy and ...
Dimitris Dalalas +5 more
doaj +5 more sources
Proton relative biological effectiveness (RBE): a multiscale problem. [PDF]
Br J Radiol, 2019 Proton radiotherapy is undergoing rapid expansion both within the UK and internationally, but significant challenges still need to be overcome if maximum benefit is to be realised from this technique. One major limitation is the persistent uncertainty in proton relative biological effectiveness (RBE).
Underwood TS, McMahon SJ.
europepmc +6 more sources
A Systematic Review of Clinical Studies on Variable Proton Relative Biological Effectiveness (RBE)
Radiotherapy and Oncology, 2022 Recently, a number of clinical studies have explored links between possible Relative Biological Effectiveness (RBE) elevations and patient toxicities and/or image changes following proton therapy. Our objective was to perform a systematic review of such studies.
Joanne Haviland +2 more
exaly +6 more sources
An Ion-Independent Phenomenological Relative Biological Effectiveness (RBE) Model for Proton Therapy
Radiotherapy and Oncology, 2022 27 pages, 10 figures (4 in the supplementary)
Christian Hahn, Armin Lühr, Liheng Tian
exaly +4 more sources
Microdosimetric characterization of proton relative biological effectiveness in pancreatic ductal adenocarcinoma cell lines [PDF]
Frontiers in OncologyPurposePancreatic ductal adenocarcinoma (PDAC) is among the most radioresistant malignancies. Proton therapy assumes a uniform relative biological effectiveness (RBE) of 1.1 regardless of radiation quality.
Tianyu Wang +9 more
doaj +2 more sources
Frontiers in Physics, 2020 The specific advantages of ion beams for application in tumor therapy are attributed to their different macroscopic and microscopic energy deposition pattern as compared to conventional photon radiation.
Michael Scholz +5 more
doaj +3 more sources
Design, implementation, and assessment of an independent second-check system for proton and carbon-ion pencil-beam scanning: delivery-aware Monte Carlo and microdosimetric RBE-weighted dose [PDF]
Frontiers in OncologyBackgroundIndependent second checks for proton and carbon-ion pencil-beam scanning should assess the planned physical dose, the expected delivery sequence, and the model-dependent relative biological effectiveness (RBE)-weighted dose.ObjectiveThe aim of ...
Jun Tan +4 more
doaj +2 more sources
A standardized measurement-based approach to estimate modelled relative biological effectiveness for auditing carbon ion beams [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: Differences in dose delivered during carbon radiotherapy are due largely to variations in relative biological effectiveness (RBE), which can be calculated by several models.
Shannon Hartzell +8 more
doaj +2 more sources